A5103141574- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Vascular Procedures and Complications
- Antibiotics Pharmacokinetics and Efficacy
- Cell Adhesion Molecules Research
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Electrospun Nanofibers in Biomedical Applications
- Pneumonia and Respiratory Infections
- Polyamine Metabolism and Applications
- Pharmacological Effects and Toxicity Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Hemoglobinopathies and Related Disorders
- Angiogenesis and VEGF in Cancer
- Pharmaceutical studies and practices
- Traumatic Ocular and Foreign Body Injuries
- Lipoproteins and Cardiovascular Health
- Bacterial Infections and Vaccines
- Cardiovascular Issues in Pregnancy
- Liver Disease and Transplantation
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
Chiba University Hospital
2015-2024
St. Marianna University School of Medicine
2014-2024
Japan Community Healthcare Organization
2023
Tokuyama (Japan)
1997-2023
Chiba University
2010-2023
Tokyo University of Science
2022
Amine Pharma (Japan)
2022
Hoshi University
2016
Ebara (Japan)
2016
Yokohama City Seibu Hospital
2016
Kefiran is an exopolysaccharide produced by Lactobacillus kefiranofaciens, and has been proposed to have many health-promoting properties. We investigated the antiatherogenic effect of kefiran on rabbits fed a high-cholesterol diet.Male New Zealand White were 0.5% cholesterol diet without (control group, n = 7) or with (kefiran 8) for eight weeks. The aorta was analyzed histochemistry atherosclerotic lesions quantified. Lipids sugars in serum measured. Foam cell formation RAW264.7 βVLDL...
Background Methadone is a unique µ-opioid receptor agonist. Although several researchers have insisted that the pharmacological effects of methadone are mediated through blockade NMDA receptor, underlying mechanism by which exerts its distinct compared to those other agonists still controversial. In present study, we further investigated profile fentanyl and morphine as measured mainly discriminative stimulus effect in vitro assays for binding, receptor-internalization, receptor-mediated...
AbstractSevere neutropenia (absolute neutrophil count <500/μ1) is probably due to the combined effects of dysregulated cytokine production and chemotherapeutic agents, one risk factors in initial treatment patients with Epstein-Barr virus-related hemophagocytic lymphohistiocytosis (EBV-HLH). We report here 9 cases neutropenic HLH, which 8 were treated cyclosporin (CSA, 2-6 mg/kg/day; continuous infusion, or 6mg/kg/day; per os, for periods ranging from days weeks) phase during induction using...
We report on sibs and their mother, all with del(18p). The propositus, an 11-month-old, had developmental delay, round face, hypertelorism, large ears, broad nasal bridge, upturned nostrils, micrognathia, a high palate, redundant skin around the neck, micropenis, cryptorchidism. elder sister, two 7/12-year-old, narrow short fingers, hypoplastic genitalia. Their mother microcephaly, prominent colu- mella, wide mouth, malaligned teeth, clinodactyly of fifth fingers. Serial photographs showed...
Dermoid cysts are non-neoplastic tumors that arise from defects in the separation of neuroectoderm. Cyst rupture rarely occurs spontaneously and most common symptom is headache, followed by seizure. Although many cases ruptured dermoid present with symptoms, reports asymptomatic, or where symptoms disappear, rare. We report case a 66-year-old Asian man history sudden onset headache who was found to have high amounts fat material subarachnoid space suppression mass left cavernous sinus. He...
Dyslipidemia is one of the onset and risk factors chronic kidney disease renal function drop seen in lipoprotein abnormal animal models. However, detailed molecular mechanism lipotoxicity has not been clarified. Therefore, present study aimed to investigate influence cholesterol overload using mouse tissue kidney-derived cultured cells.C57BL/6 mice were fed normal diet (ND) or 1.25% cholesterol-containing high-cholesterol (HCD) for 11 weeks, we used megalin as a proximal tubule marker...
Intracranial vascular complications following radiosurgery are extremely rare.We report a case of stenosis in the internal carotid artery 5 years after gamma knife for recurrent pituitary adenoma. Percutaneous transluminal angioplasty was performed successfully with anatomical and functional improvement.These results suggested importance monitoring arterial long-term follow-up. Moreover, this is first endovascular treatment as an effective therapy intracranial due to radiotherapy.
Background. Although several epidural catheterizations in small animals have been reported, all of them were performed surgically and no percutaneous method has reported. We established a technique for chronic catheterization rabbits. Methods. Following pentobarbital anesthesia, the (n=15) fixed prone position using fixing apparatus. A 19‐gauge Tuohy needle was inserted lumbar region at an angle about 30° to skin with paramedian approach advanced into space loss‐of‐resistance method....
Background: Dedifferentiated rabbit vascular smooth muscle cells (SMCs) exhibit similar features to differentiated SMCs when cultured in three-dimensional matrices of type-I collagen called "honeycombs," but the mechanism is unknown. The role filamin, an actin-binding protein that links actin filaments SMCs, was investigated. Methods: Filamin and other related proteins were detected by western blot analysis immunofluorescence staining. Honeycomb size measured confirm contraction SMCs....
A 7-year-old boy presented with a longitudinal clival fracture following traffic accident. The only temporary unconsciousness despite suffering of the clivus. Fractures clivus are often caused by severe head trauma, and mortality rate is high due to coexisting injury adjacent vessels, brain stem, lower cranial nerves. Review radiological clinical findings fractures found that all reported pediatric patients fracture, including present case, suffered an occipital impact, whereas majority in...
Anterior communicating artery (ACoA) aneurysms have a complex architecture and many variations, making endovascular therapy more difficult in some cases. The aim of this study was to investigate whether the neck position an aneurysm identifiable for determining immediate angiographic success procedural complications coiling ACoA aneurysms. We conducted retrospective case review 40 patients with treated by from 2008 2015. mean age 66.8 years. Thirty-five were ruptured; five unruptured. For...
Summary Nemaline myopathy is a rare congenital associated with skeletal deformities and respiratory complications. Three children nemaline who underwent cardiac surgery are described where the heart rate decreased during induction of anaesthesia body temperature increased or after surgery. The anaesthetic implications in management patients discussed.
Background: Although continuous hemodiafiltration (CHDF) is often performed in critically ill patients during sepsis treatment, the pharmacokinetics of vancomycin (VCM) CHDF with a polymethylmethacrylate hemofilter (PMMA-CHDF) have not been revealed. In this study, authors aimed to describe population VCM undergoing PMMA-CHDF and clarify its clearance (CL ). Methods: This single-center, retrospective study enrolled who underwent intravenous therapy at intensive care unit Chiba University...
A 79-year-old woman presented with a subarachnoid hemorrhage. Angiography revealed pseudoaneurysm formation due to rupture of true saccular anterior communicating artery aneurysm. Coil embolization, limited the aneurysm, was performed successfully favorable clinical outcome. This procedure can be considered as an alternative treatment option for similar aneurysms in cases where surgical clipping is contraindicated.
症例は, 無症候のため半年間経過観察された慢性硬膜下血腫 (chronic subdural hematoma : CSDH) の81歳男性. ADL低下と発熱を主訴に来院した. 入院し熱源精査中の5日目に左片麻痺をきたし, 既存血腫に対し穿頭術を施行した. 血液の混じった膿汁が排液され, 感染性硬膜下血腫 (infected ISH) と診断した. その後再発し, 穿頭術を2回施行した. 抗菌薬で炎症反応も軽快し, 病変は画像上器質化したと判断された. 発熱と炎症反応を伴うCSDHはISHの可能性があり注意が必要である. 診断および治療に苦慮した経過の詳細を記載し, 過去の報告例を分析した.