Lung adenocarcinoma (LUAD) frequently precipitates a hypercoagulable state, resulting in venous thromboembolism and associated hemostatic complications. Furthermore, the coagulation cascade holds pivotal role within tumor microenvironment (TME) of LUAD. Utilizing unsupervised clustering coagulation-related genes (CRG) integrating clinical attributes, distinctions correlations across various groups were assessed. Principal component analysis (PCA) was employed to derive CRGscore for LUAD...

Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer, representing 40% all cases this tumor. Despite immense improvements in understanding molecular basis, diagnosis, and treatment LUAD, its recurrence rate still high.RNA-seq data from The Cancer Genome Atlas (TCGA) LUAD cohort were download Genomic Data Commons Portal. GSE13213 dataset Gene Expression Omnibus (GEO) was used for external validation. Differential prognostic lysosome-related genes (LRGs) identified by...

In recent years, cell membrane drug delivery systems have received increasing attention. However, drug-loaded targeting therapy in myocardial ischemia-reperfusion injury (MIRI) been relatively rarely studied. The purpose of this study was to explore the protective effect platelet-membrane-encapsulated Carvedilol on MIRI. We extracted platelets from blood adult SD rats and prepared platelet vesicles (PMVs). Carvedilol, a nonselective β-blocker, encapsulated into PMVs. order determine best...

Idiopathic pulmonary fibrosis (IPF), a type of interstitial lung disease (ILD), is chronic with an unknown etiology. The occurrence cancer (LC) one the main causes death in patients IPF. However, pathogenesis driving these malignant transformations remains unclear; therefore, this study aimed to identify shared genes and functional pathways associated both conditions.Data were downloaded from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. To overlapping diseases, "limma"...

Abstract Background Lung adenocarcinoma (LUAD) is one of the tumor‐related diseases with high morbidity worldwide. Epigenetic modifications such as DNA methylation changes may involve in tumorigenesis. This study aimed to explore new biomarkers that have prognostic significance LUAD. Methods First, we downloaded gene expression and data set from Gene Expression Omnibus. R software was then used identify abnormally methylated differentially expressed genes (MDEGs). Next, package Cluster...

BackgroundBiomaterials can improve cardiac repair combined with transplantation of bone marrow mononuclear cells (BMMNCs). In this study, we compared the phenotype and between human heart valve-derived scaffold (hHVS) natural protein/polycaprolactone (NP/PCL) anchored BMNNCs.Methods ResultsBMMNCs were obtained from mice five days following myocardial infarction. Subsequently, BMMNCs separately cultured on hHVS PCL. Proliferation cardiomyogenic differentiation detected in vitro. Cardiac...

Abstract Background Lung adenocarcinoma (LUAD) is a major subtype of lung cancer and closely associated with poor prognosis. N6-methyladenosine (m6A), one the most predominant modifications in mRNAs, found to participate tumorigenesis. However, potential function m6A RNA methylation tumor immune microenvironment still murky. Methods The gene expression profile cohort its corresponding clinical data LUAD patients were downloaded from TCGA database GEO database. Based on 21 regulators, we...

Abstract Lung adenocarcinoma (LUAD) is characterized by high infiltration and rapid growth. The function of the stem cell population to control maintain regeneration. Therefore, it necessary study prognostic value cell-related genes in LUAD. Signature were screened out from 166 according least absolute shrinkage operator (LASSO) subsequently multivariate Cox regression analysis, then established risk model. Immune nomogram model used evaluate clinical efficacy signature. A signature...

Despite its involvement in nucleotide metabolism, tumor immune landscape, and immunotherapy response, the role of 2'-3'-cyclic guanosine monophosphate-adenosine monophosphate (2',3'-cGAMP) lung adenocarcinoma (LUAD) remails unelucidated. This study aimed to investigate antitumor effects 2',3'-cGAMP LUAD.

Nuclear factor erythroid 2-related 2 (Nrf2) has been shown to ameliorate early ischemia-reperfusion (I/R) injury after activation by tertiary butylhydroquinone (TBHQ). However, despite macrophage-associated inflammation being a distinguishing feature of I/R injury, the precise roles and mechanisms Nrf2 in are still poorly understood.I/R hypoxia/reperfusion (H/R) models were constructed vivo using rats vitro H9C2 rat cardiomyoblast cell line, respectively. The effects TBHQ on myocardial...

Esophageal cancer (ESCA) is one of the most commonly diagnosed cancers in world. Tumor immune microenvironment closely related to tumor prognosis. The present study aimed at analyzing competing endogenous RNA (ceRNA) network and tumor-infiltrating cells ESCA.The expression profiles mRNAs, lncRNAs, miRNAs were downloaded from Cancer Genome Atlas database. A ceRNA was established based on differentially expressed RNAs by Cytoscape. CIBERSORT applied estimate proportion ESCA....

Interleukin 34 (IL-34), an additional ligand of the colony-stimulating factor-1 receptor (CSF-1R), promotes secretion pro-inflammatory cytokines and stimulates NF-κB JNK-related signaling pathways. However, potential mechanism prognostic value IL-34 in lung adenocarcinoma (LUAD) remain obscure. In this study, was found to be downregulated LUAD tissues compared with para-carcinoma tissues, loss expression correlated shorter overall survival (OS), which validated by bioinformatics\ analysis...

Abstract Lung cancer is one of the most common malignant tumors, and ranks high in list mortality due to cancers. adenocarcinoma (LUAD) subtype lung cancer. Despite progress diagnosis treatment cancer, prognosis these patients remains dismal. Therefore, it crucial identify predictors targets provide appropriate treatments improve patient prognosis. In this study, gene modules related immunotherapy were screened by weighted co-expression network analysis (WGCNA). Using unsupervised...

DNA methylation is an important part of epigenetic modification, and its abnormality closely related to esophageal adenocarcinoma (EAC). This study was aimed at using bioinformatics analysis identify methylation-driven genes (MDGs) in EAC patients establish a risk model as biological indicator prognosis.Downloaded methylation, transcriptome, clinical data from TCGA database. MethylMix used MDGs. R package clusterProfiler the ConsensusPathDB online database were analyze rich functions...

The development of non-small cell lung cancer (NSCLC) is very rapid, and the effect its treatment often closely related to diagnosis time disease. Therefore, simple convenient tumor biomarkers are helpful for timely prevention NSCLC.Through univariate multivariate Cox regression analyses, SMOX was determined as an independent prognostic factor GSE42127, GSE41271, GSE68465, TCGA datasets. Furthermore, western blot, reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemical...

The mechanisms of hypoxia or immune microenvironment in cancer have been studied respectively, but the role non-small cell lung (NSCLC) still needs further exploration.By applying K-means algorithm, 1,121 patients with NSCLC were divided into three categories. We evaluated constructed signature order to link it prognosis, which was by univariate and least absolute shrinkage operator (LASSO) Cox regression analysis.A total clusters obtained clustering five Gene Expression Omnibus (GEO) data...

Interleukin 6 (IL6) is both a pleiotropic cytokine and an immune-related gene. receptor (IL6R) the for IL6. It may be closely connected to development of lung cancer. This research aims explore prognostic value IL6R prevent overtreatment patients with adenocarcinoma (LUAD).In this study, expression in tumor tissues surrounding was first analyzed by immunohistochemistry Affiliated Hospital Nantong University (NTU) cohort. Secondly, we downloaded information from The Cancer Genome Atlas (TCGA)...

Abstract Phosphorylation is essential for tumor-induced angiogenesis, but how it affects angiogenesis remains unclear. We introduced phosphorylation-related genes from the lung adenocarcinoma dataset, screened out most characteristic PBK through various machine learning methods, and repeatedly verified their survival data, mutation frequency, clinical information. Subsequently, we conducted a comprehensive analysis of whole cancer based on adenocarcinoma, analyzed 33 cases pan-cancer by GSEA...

Several studies have reported the role of polycomb group (PcG) genes in human cancers; however, their lung adenocarcinoma (LUAD) is unknown.Firstly, consensus clustering analysis was used to identify PcG patterns among 633 LUAD samples training dataset. The were then compared terms overall survival (OS), signaling pathway activation, and immune cell infiltration. PcG-related gene score (PcGScore) developed using Univariate Cox regression least absolute shrinkage selection operator (LASSO)...

Abstract Lung cancer is one of the most common malignant tumors, and ranks high in list mortality due to cancers. adenocarcinoma(LUAD) subtype lung cancer. Despite progress diagnosis treatment cancer, prognosis these patients remains dismal. Therefore, it crucial identify predictors targets provide appropriate treatments improve patient prognosis. In this study, gene modules related immunotherapy were screened by weighted co-expression network analysis (WGCNA). Using unsupervised clustering,...

Abstract Background : Adenocarcinoma is characterized by high infiltration and negative growth, which easy to invade the walls of blood vessels lymphatic vessels. The function stem cell population control maintain regeneration. Therefore, it necessary study prognostic value cells in LUAD. Methods: Stem signature construction relies on univariate, least absolute shrinkage operator (LASSO) multivariate Cox regression analysis. Risk plot, Kaplan-Meier analysis area under ROC (AUC) are verified...