A5046269118- Photochromic and Fluorescence Chemistry
- Porphyrin and Phthalocyanine Chemistry
- Nonlinear Optical Materials Studies
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Nanocluster Synthesis and Applications
- Advanced Fluorescence Microscopy Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Photoreceptor and optogenetics research
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Supramolecular Self-Assembly in Materials
- Photochemistry and Electron Transfer Studies
- Synthesis of heterocyclic compounds
- Protein Interaction Studies and Fluorescence Analysis
- Laser-Ablation Synthesis of Nanoparticles
- Sulfur-Based Synthesis Techniques
- Polymer composites and self-healing
- Organic Chemistry Synthesis Methods
- Advanced Biosensing Techniques and Applications
- Organic Light-Emitting Diodes Research
Institut National des Sciences Appliquées Rouen Normandie
2018-2024
Centre National de la Recherche Scientifique
2012-2024
Université de Rouen Normandie
2018-2024
Laboratoire COBRA
2017-2024
Normandie Université
2018-2023
Génétique Moléculaire Génomique Microbiologie
2019-2022
Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation
2021
Nantes Université
2021
Institut Químic de Sarrià
2014-2020
Universitat Ramon Llull
2014-2020
Over the last 20 years, number of pathogenic multi-resistant microorganisms has grown steadily, which stimulated search for new strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT), also called inactivation, is emerging as a promising alternative treatments based on conventional antibiotics. We have explored effectiveness methylene blue-loaded targeted mesoporous silica nanoparticles (MSNP) in inactivation two Gram negative bacteria, namely Escherichia...
Numerous research efforts are investigating the possibility of using light interactions with metallic nanoparticles to improve fluorescence properties nearby molecules. Few investigations have considered encapsulation molecules in nanocavities. In this paper, we present optical new hybrid consisting gold nanoshells and fluorescent organic dyes their liquid cores. Microspectroscopy on single nanoparticle demonstrates that extinction spectra good agreement Mie's theory. Finite difference time...
High two-photon photolysis cross sections and water solubility of probes are important to avoid toxicity in biomedical applications photolysis. Systematic variation the position a carboxyl electron-withdrawing group (EWG) on 8-dimethylaminoquinoline protecting groups identified C5-substituted isomer as privileged dipole. The 5-benzoyl-8-DMAQ substitution yields caging with an enhanced uncaging section (δu = 2.0 GM) good (c ≤ 50 mM, pH 7.4).
The systematic SAR study of a "caging" group showed strong influence the position donor dimethylamino on efficiency photolysis DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease l-glutamate by most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited photoreleased from widely used MNI-caged glutamate.
A chromophore featuring a diyne bridge that connects two dibromobenzene moieties shows much improved two-photon singlet oxygen generation ability in the biological transparency window compared to related and relevant literature benchmark, as result of distorted ground state.
Abstract Molekulare Systeme, die mit Licht “ferngesteuert” werden können, sind von wachsender Bedeutung in der Zellbiologie, Physiologie und den Neurowissenschaften. Der entscheidende Aspekt hierbei ist hohe räumliche zeitliche Präzision, Methoden Lasermikroskopie erreicht kann. Das Verfahren Zwei‐Photonen‐Anregung hat signifikante Vorzüge bei Visualisierung biologischer Gewebe, allerdings gezielte Entwurf intelligenter Sonden, Zellphysiologie kompatibel sind, nicht trivial. Dieser Aufsatz...
Abstract Reduced scattering and autofluorescence in the second near‐infrared window (NIR‐II, 1000–1700 nm) hold promise of high‐resolution photoluminescence (PL) vivo imaging at depths well beyond µm scale. Yet, contrast agents with bright emission this spectral region remain limited. Ultrasmall gold nanoclusters (AuNCs) are particular interest for NIR‐II PL imaging. However, they exhibit limited brightness. Here, high amounts emitting AuNCs encapsulated small polymer nanoparticles (NPs)...
A versatile approach is introduced for the synthesis of well-defined, biocompatible conjugates combining two-photon chromophores and hydrophilic multifunctional polymers synthesized by RAFT controlled radical polymerization. As an illustration, two different classes carrying multiple fluorophores (based on anthracene moiety, Anth) or photosensitizers a dibromobenzene DBB) along polymer chain were elaborated bioimaging photodynamic therapy (PDT) applications, respectively. In both cases,...
Binding of red-absorbing porphycene isothiocyanates to proteins and nanoparticles leads near-IR fluorescent photosensitising conjugates.
Cell Imaging Platforms (CIPs) are research infrastructures offering support to a number of scientific projects including the choice adapted fluorescent probes for live cell imaging. What detect in what type sample and how long is major issue with and, this, “hat-trick” “Probe–Sample–Instrument” (PSI) has be considered. We propose here deal key points usually discussed CIPs properties organic probes, modality labeling, best equipment obtain appropriate spectral, spatial, temporal resolution....
A molecular engineering strategy based on rational variations of the bromine substitution pattern in two-photon absorbing singlet oxygen sensitizers allows studying relations that exist between positioning an inter-system crossing promoter charge-transfer chromophore and its ability to generate oxygen.
The nitrosation of indoles under slightly acidic conditions and reverse addition leads to the preparation corresponding indazole-3-carboxaldehydes in high yields greatly minimizes side reactions.
Quadrupolar 8-dimethylaminoquinoline-derived photosensitive probes underwent photolysis under UV (365 nm) and NIR (730 nm two-photon (TP)) irradiation conditions.
Two-photon photosensitizers with heavy atom substituents were synthesized and evaluated through a combined photophysical computational study.
We report the preparation of gold nanoclusters (AuNCs) as a delivery vehicle for clinically approved photodynamic and chemotherapeutic agents Protoporphyrin IX (PpIX) doxorubicin (DOX), respectively, their effect on tumor cells. DOX was attached to through singlet oxygen-cleavable linker therefore released after PpIX irradiation with red light, contributing, synergistically oxygen, induce cell death. The doubly functionalized AuNCs proved more effective than combination individually AuNCs....
Abstract Photoactive transition‐metal complexes are luminophores combining high photostability and long luminescence lifetimes. However, reduced optical performance in aqueous solutions has limited their use biological systems. Herein, the physicochemical photophysical properties bioimaging compatibility of Re diimine near‐infrared (NIR) emitting Cy5 dyes coencapsulated polymer nanoparticles (NPs) investigated. By varying polymers, NPs with sizes from 20 to 70 nm encapsulating ≤ 40 wt.%...
Epicocconone 1 is a natural chromophore isolated from the fungus Epicoccum nigrum that has shown applications in proteomics and fluorescent microscopy thanks to its unique pro-fluorescence properties. The modification of skeleton product by replacing triene side chain fluorenyl scaffold can noticeably increase fluorophore's absorption coefficient. synthesis analogues been made possible use palladium-catalyzed carbonylation reaction, allowing construction β-keto-dioxinone key intermediate....