A5038651021- Vasculitis and related conditions
- Urticaria and Related Conditions
- Otitis Media and Relapsing Polychondritis
- Monoclonal and Polyclonal Antibodies Research
- Kawasaki Disease and Coronary Complications
- Systemic Lupus Erythematosus Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiovascular Issues in Pregnancy
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- Dermatological and COVID-19 studies
- Glycosylation and Glycoproteins Research
- Drug-Induced Adverse Reactions
- Autoimmune and Inflammatory Disorders
- Mast cells and histamine
- Infectious Diseases and Tuberculosis
- Biliary and Gastrointestinal Fistulas
- Chronic Lymphocytic Leukemia Research
- Cerebral Venous Sinus Thrombosis
- Vitamin C and Antioxidants Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infections and bacterial resistance
- Infectious Disease Case Reports and Treatments
Centre Hospitalier Universitaire de Tours
2016-2024
Université de Tours
2016-2024
Centre Val de Loire
2023
Hôpital Bretonneau
2022-2023
IgA vasculitis (IgAV) can occur after vaccination. We aimed to assess a potential safety signal on the association between coronavirus disease 2019 (COVID-19) vaccines and IgAV.Cases of IgAV involving COVID-19 were retrieved in VigiBase. Disproportionate reporting was assessed using Bayesian information component (IC) with all other drugs as control groups.Three hundred thirty patients de novo from 24 countries included, mostly United States (193/330, 58%). Fifty percent (163/328) female...
Objective Immunoglobulin A vasculitis (IgAV) usually occurs following viral respiratory tract infection. In the context of global coronavirus disease 2019 (COVID-19) pandemic, we describe a case series patients who developed IgAV SARS-CoV-2 Methods This national multicenter retrospective study included with infection from January 1, 2020, to 2022. Patients had histologically proven and reverse transcription PCR (RT-PCR)-proven The interval between onset be < 4 weeks. Results We 5...
The worldwide coronavirus disease 2019 (COVID-19) vaccination campaign triggered several autoimmune diseases. We hereby aimed to describe IgA vasculitis (IgAV) following COVID-19 vaccination.We conducted a national, multicenter, retrospective study in France of new-onset adult IgAV diagnosis vaccination.In total, 12 patients with were included. Of these, 5 (41.7%) women, and the median age was 52.5 (IQR 30.75-60.5) years. patients, 10 had received an mRNA vaccine 2 viral vector vaccine. time...
The neonatal Fc receptor (FcRn) is a ubiquitously expressed protein historically involved in IgG and albumin recycling. Recent data suggest an involvement the pathophysiology of antibody-mediated autoimmune diseases. Among them, systemic lupus erythematosus (SLE) implies clinical biological abnormalities innate adaptive circulating immune cells, potentially involving newly described functions FcRn. In this study, FcRn expression was assessed by flow cytometry peripheral blood leukocytes 41...
Abstract Introduction IgA vasculitis diagnosis relies primarily on clinical features and is confirmed by pathological findings. To date, there no reliable noninvasive diagnostic biomarker. Objective We aimed to explore the baseline serum metabolome of adult patients with identify potential biomarkers. Methods performed a study comparing that inflammatory condition, namely spondyloarthritis. Serum analyses were high-performance liquid chromatography-mass spectrometry. Results Fifty-five 77...
<h3>Background:</h3> Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) primarily affects small vessels. Large-vessel involvement (LVI) is rare. <h3>Objectives:</h3> We aimed to describe the characteristics of LVI, identify associated risk factors, and its therapeutic management. <h3>Methods:</h3> This multicenter case-control (1:2) study included patients with AAV according ACR/EULAR classification [1] LVI as defined by Chapel Hill nomenclature [2], together controls...
Objective Data on obstetric outcomes in patients with a history of immunoglobulin A vasculitis (IgA-V) are lacking. The aim this study was to assess maternal, neonatal, and during pregnancy.Method We conducted French retrospective case–control study. Pregnancies IgA-V (cases) were retrospectively studied compared pregnancies women who developed after their healthy (controls).Results Twenty-six included 15 later 52 women. Both gestational hypertension pre-eclampsia more frequent the case...
•Vascular inflammation may be linked to Campylobacter coli infection.•Post-infectious vasculitis cause relapsing fever after an acute infection.•18F-fluorodeoxyglucose positron emission tomography/computed tomography helpful for the diagnosis of post-infectious vasculitis. A 56-year-old male with no comorbidity was admitted at 40°C diarrhea and night sweats, 3 weeks initial onset without microbiological screening in December 2020. Blood analysis showed C-reactive protein 251.5 mg/l negative...
<h3>Background</h3> IgA vasculitis (IgAV) is a rare autoimmune disease affecting small vessels. It well established that the incidence higher in children (3 to 26 per 100,000 children/year,) <sup>[1]</sup> than adults (0.1 1.8 individuals/year) <sup>[1]</sup>. However others epidemiological data and impact of COVID-19 on IgAV remain overlooked <sup>[2]</sup>. <h3>Objectives</h3> To collect analyze both France. <h3>Methods</h3> We conducted an observational study using national database...
<h3>Background</h3> It has been shown that patient's demographical characteristics may impact presentation and outcome in adult IgA vasculitis (IgAV). Aging was to negatively disease severity of IgAV. IgAV is also known be more frequent male, with a male female gender ratio 1.6. However, the potential during overlooked. <h3>Objectives</h3> We aimed study on <h3>Methods</h3> retrospectively data French retrospective multicenter cohort (IGAVAS), including 260 patients. Comparison were...
L'artérite à cellule géante (ACG) est une cause classique de syndrome inflammatoire prolongé du sujet âgé provoquant des céphalées, hypersensibilité scalp et claudication mâchoires. Nous rapportons l'observation d'un patient atteint d'une ACG révélée par inflammation biologique perte poids évoluant depuis 1 an. Le diagnostic a été posé sur biopsie systématique l'artère temporale montrant caractéristiques histologiques typiques. Aucun traitement n'a envisagé car le était entré en rémission...
Adult IgA vasculitis (IgAV) is more common in males, but the potential impact of gender remains unclear. We aimed to describe on presentation and outcome adult IgAV. retrospectively analysed data from a multicentre retrospective cohort 260 patients (IGAVAS). Comparisons were made according status. Data 259 (95 females 164 males) analysed. Compared with females, baseline males was similar for cutaneous involvement (100% vs 100%, P = 1.0), joint (60% 63%, 0.7), gastrointestinal (57% 45%,...
Background: IgA vasculitis diagnosis relies primarily on clinical features and is confirmed by pathological findings. To date, there no reliable noninvasive diagnostic biomarker.Objective: We aimed to explore the baseline serum metabolome of adult patients with identify potential biomarkers. Methods: performed a study comparing that inflammatory condition, namely spondyloarthritis. Serum analyses were high-performance liquid chromatography-mass spectrometry. Results: Fifty-five 77 controls...