A5024960922- Neurological Complications and Syndromes
- Pharmacovigilance and Adverse Drug Reactions
- Pharmacological Effects and Toxicity Studies
- Electrolyte and hormonal disorders
- Anesthesia and Sedative Agents
- Electroconvulsive Therapy Studies
- Epilepsy research and treatment
- Vascular Malformations and Hemangiomas
- Pregnancy and preeclampsia studies
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Drug-Induced Adverse Reactions
- Tumors and Oncological Cases
- Renal Transplantation Outcomes and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Facial Nerve Paralysis Treatment and Research
- Amyotrophic Lateral Sclerosis Research
- Peripheral Neuropathies and Disorders
- Teratomas and Epidermoid Cysts
- Cardiac electrophysiology and arrhythmias
- Immune cells in cancer
- Biosimilars and Bioanalytical Methods
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Metabolism and Genetic Disorders
- Chronic Lymphocytic Leukemia Research
Centre Val de Loire
2019-2025
Centre Hospitalier Universitaire de Tours
2017-2025
Université de Tours
2017-2024
Université de Lille
2022
Centre Hospitalier Universitaire de Lille
2021-2022
Inserm
2019-2022
Lille Neurosciences & Cognition
2022
Groupe de Recherche sur l'Alcool et les Pharmacodépendances
2021
Centre d'Investigation Clinique de Nantes
2020
Laboratoire de Microbiologie et Génétique Moléculaires
2019
Although several case series have described nitrous-oxide-associated neurological disorders, a comprehensive assessment of exposure characteristics (e.g., time to onset, level exposure) in substance abusers has not been performed. The aim this study was describe the onset patterns recreational use nitrous-oxide-induced disorders. All cases disorders related nitrous oxide reported Hauts-de-France addictovigilance center between January 2019 and August 2020 were selected. Only requiring...
IgA vasculitis (IgAV) can occur after vaccination. We aimed to assess a potential safety signal on the association between coronavirus disease 2019 (COVID-19) vaccines and IgAV.Cases of IgAV involving COVID-19 were retrieved in VigiBase. Disproportionate reporting was assessed using Bayesian information component (IC) with all other drugs as control groups.Three hundred thirty patients de novo from 24 countries included, mostly United States (193/330, 58%). Fifty percent (163/328) female...
Gabapentinoids are ligands of the α2-δ subunit voltage-gated calcium channels (Cav) that have been associated with a risk peripheral edema and acute heart failure in connection potentially dual mechanism, vascular cardiac.All cases or involving gabapentin pregabalin reported to French Pharmacovigilance Centers between January 1, 1994 April 30, 2020 were included describe their onset patterns (e.g., time onset). Based on these data, we investigated impact gabapentinoids myogenic tone rat...
Abstract Background Lingual microcystic lymphatic malformations (LMLMs) are rare congenital vascular presenting as clusters of cysts filled with lymph fluid or blood. Even small well-limited lesions can be responsible for a heavy burden, inducing pain, aesthetic prejudice, oozing, bleeding, infections. The natural history LMLMs is progressive worsening punctuated by acute flares. Therapeutic options include surgery, laser excision, and radiofrequency ablation but all potentially detrimental...
Abstract Background Growing evidence indicates that amoxicillin induces herpesvirus replication in vitro . As these play a central pathophysiological role Drug Reaction with Eosinophilia and Systemic Symptoms syndrome (DRESS), could present specific DRESS features. Objective To characterize the onset patterns of amoxicillin‐associated DRESS. Methods All cases (Kardaun score ≥4) involving reported French Pharmacovigilance Database between January 1, 2004 November 30, 2019 were included. Onset...
Introduction: Pazopanib is an oral protein kinase inhibitor (PKI) that targets vascular endothelial growth factor (VEGF) receptors, fibroblastic platelet-derived and stem cell inhibits VEGF-induced cellular proliferation. approved for use in advanced renal carcinoma subtypes of soft-tissue sarcoma (Deguchi et al., 2018). Major adverse drug reactions pazopanib include hypertension, high-grade hyponatremia posterior reversible encephalopathy syndrome (PRES) (Berardi 2016; Deguchi In clinical...
Background: Selection of expected phenotypes (ie, expressers/non-expressers) is currently used in CYP3A5*3 genotype-based tacrolimus dosing. The authors assessed whether a dosing regimen based on the 3 CYP3A5 genotypes may reduce occurrence inadequate exposure. Methods: Tacrolimus whole blood trough levels ( C 0 ) were retrieved from retrospective cohort 100 kidney transplant recipients treated with starting dose 0.15 (non-expressers) or 0.30 (expressers) mg/kg/d. evaluated overexposures (12...
Abstract Aims Gabapentin and pregabalin bind to α2‐δ subunit of voltage‐gated calcium channels (Ca v ). Other drugs targeting Ca include cardiovascular channel blockers (CCBs) anticonvulsants (levetiracetam, ethosuximide zonisamide). In addition pharmacodynamics, the safety profile gabapentinoids seems overlap with one CCBs (oedema) ‐blocking (suicide ataxia). The objective this study was cluster different ‐ligand by focusing on whether present a distinct adverse drug reaction (ADR)...
In clinical trials, few investigations have been conducted to determine the mechanism involved in teriflunomide-associated kidney stone formation. We report first case of recurrent teriflunomide-induced uric acid urolithiasis. A 55-year-old man with relapsing-remitting multiple sclerosis experienced three occurrences urolithiasis several months after initiation teriflunomide. While serum remained stable at 280 mmol/L, 24-h urine was increased 2195 mmol/24 h. For third episode, computed...