A5054262622- Microscopic Colitis
- Inflammatory Bowel Disease
- Celiac Disease Research and Management
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Galectins and Cancer Biology
- Reproductive tract infections research
- Immune Response and Inflammation
- Diabetes and associated disorders
- Gastrointestinal motility and disorders
- Immune Cell Function and Interaction
- Oral microbiology and periodontitis research
- Gut microbiota and health
- Reproductive System and Pregnancy
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Liver Diseases and Immunity
- Urinary Tract Infections Management
- T-cell and B-cell Immunology
- Gastrointestinal disorders and treatments
- Cervical Cancer and HPV Research
- Multiple Sclerosis Research Studies
Vrije Universiteit Amsterdam
2004-2022
University Medical Center
2002-2022
Amsterdam UMC Location Vrije Universiteit Amsterdam
2006-2018
Immungenetics (Germany)
2002-2015
Universidad Nacional de La Plata
2015
Consejo Nacional de Investigaciones Científicas y Técnicas
2015
Zhongnan Hospital of Wuhan University
2004-2015
Biology of Infection
2015
Wuhan University
2004-2015
Verein zur Förderung Agrar- und Stadtökologischer Projekte
2015
The discovery of a series genetic and serological markers associated with disease susceptibility phenotype in inflammatory bowel has led to the prospect an integrated classification system involving clinical, parameters. Working Party reviewed current clinical systems Crohn’s disease, ulcerative colitis indeterminate colitis, provided recommendations for practice. Progress respect integrating been examined detail, implications are discussed. While is not proposed use at present, introduction...
The genes for tumour necrosis factor alpha (TNFα) and lymphotoxin (LTα; TNFβ) are tandemly arranged in the central region of MHC. They may, therefore, be importance aetiology MHC‐associated diseases. authors have prospectively studied secretion TNFα LTα relation to polymorphisms at positions ‐308 ‐238 gene (TNFA), two first intron (LTA), as well HLA‐DR 30 patients with chronic inflammatory bowel diseases (IBD) 12 healthy controls. In Dutch population, alleles these four present only five...
During the period 1938-70 there were 303 patients at Radcliffe Infirmary, Oxford, diagnosed as suffering from Crohn's disease. Of these, 82 have been excluded, leaving 221 with a firm diagnosis. These divided into 'new cases', in which disease was and 'referred cases' diagnosis already made time of referral. In this series, three main sites involvement: small intestinal, large both intestinal. Ileocolitis commonest anatomical distribution. The showed progression to new, considerable number...
The DR-locus controlled B-cell antigens were studied in 163 unrelated Spanish coeliac children and 68 families of this group, nine them with more than one patient, to obtain information about the association between these disease. results show that most common phenotypes are DR3/DR7, DR7/DR5, DR3/other DR, DR3/DR3. family study confirmed segregation disease above mentioned phenotypes. In eight multiple case families, all shared both HLA-DR antigens. These findings make it unlikely a single...
To investigate whether polymorphisms in the interleukin (IL)-1beta and IL-1 receptor antagonist (IL-1RA) genes are associated with both susceptibility to clinical characteristics of MS.Genetic MS is determined by many partially identified genes. The encoding various cytokines logical candidates for phenotype.Genotypes were from 148 patients clinically definite 98 healthy controls. All unrelated, Dutch, white. Patient files reviewed disease type, initial symptoms, age at onset disease, rate...
Oxygen derived radicals contribute to tissue injury in inflammatory bowel disease. We measured the content of superoxide dismutase and metallothionein (two endogenous copper zinc containing proteins involved radical scavenging) intestinal resection specimens from 29 patients with Crohn9s disease 12 ulcerative colitis compared concentrations those obtained normal mucosa a control group 18 colorectal cancer. The was similar non-inflamed (mean (SEM) 2.13 (0.10) 2.24 mg/g protein, respectively)...
Abstract We traced the Chlamydia trachomatis L2b variant in Amsterdam and San Francisco. All recent lymphogranuloma venereum cases were caused by variant. This was also present 1980s Thus, current "outbreak" is most likely a slowly evolving epidemic.
Features of the neutrophil oxidative metabolism and enzyme activity in peripheral blood neutrophils were studied 43 patients with Crohn9s disease, 13 ulcerative colitis 33 healthy controls. The production superoxide anion (O2-.) by phorbol-myristate-acetate stimulated from disease was significantly diminished compared controls mean (SE) = 47.1 (3.6) 38.0 (3.8) v 67.4 (7.5) nmol/10(7) cells/min, p less than or equal to 0.02, respectively, while hydrogen peroxide normal. content dismutase...
Two hundred and ten patients with Crohn's disease (CD) were identified in an epidemiological survey of inflammatory bowel the Leiden Health Care Region Netherlands. The included all CD seen between 1979-1983. duration ranged from less than one year to 48 years. Of 210 CD, 118 (56%) underwent surgical resection. Sixty had ileocaecal resection, 14 a proctocolectomy, seven cases as two stage procedure; 12 segmental colectomy end-to-end anastomosis eight subtotal ileostomy. Twenty-one these...
Background: In the last few years prevalence of celiac disease (CD) seems to have increased. It is clear that subclinical and silent CD exist in a large subgroup population. Methods: The aim this study was evaluate an apparently healthy Blood samples were obtained from 1000 blood donors at Arnhem Nijmegen Donation Centers January 1997 through April 1998. Sera 660 assayed for total IgA. By means immunofluorescence, antibodies, including those endomysium (EMA), determined. Serum immunoglobulin...
Six hundred and seventy one patients (52.5% women) with Crohn9s disease seen at Leiden University Hospital between 1934 1984 were identified. Follow up was 98.2% complete. Sixty four (9.7%) of the 659 died. The cause death related to in 34 patients, probably four, unrelated, from incidental causes, 25. could not be identified patient. There a significant decrease deaths after 1973. Causes such as amyloidosis malnutrition have disappeared postoperative decreased. standardised mortality ratio...
We have investigated the correlation of 24 h and 48 faecal Indium-111 excretion with each other several clinical activity indices for Crohn9s disease (CD): index (CDAI), (AI), simple (SI), Oxford score, laboratory parameters, such as ESR, serum albumin, orosomucoid, C-reactive protein, alpha-l-antitrypsin (alpha 1-AT) concentration, alpha 1-AT clearance in 58 CD patients (37 small bowel 21 colonic disease). A significant was found between (r = 0.708, p less than 0.0001) 0.994, 0.0001). The...
Bacterial deposits, smoking, and host genetic factors play a major role in an individual’s predisposition to periodontitis. components are recognized by CD14 toll-like receptor 4 (TLR4), resulting NF-κB-based inflammatory response. We hypothesized that functional TLR4 polymorphisms contribute periodontitis susceptibility. aimed investigate the occurrence of CD14-260C>T, 299Asp>Gly, 399Thr>Ile gene adult periodontititis. DNA was collected from 100 patients with severe 99...
AbstractJejunal biopsy with disaccharidase assay has been performed on 81 patients the irritable colon syndrome. Most of were British natives and stock. Nine them (12.3%) had hypolactasia, a proportion which is only little higher than found in healthy volunteers other control subjects. A small number subjects develop syndrome simply because underlying hypolactasia such respond to lactose-free diet; there four patients. In others, appears be coincidental finding. It concluded that plays minor...