A5052169736- Autism Spectrum Disorder Research
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Family and Disability Support Research
- Genetics and Neurodevelopmental Disorders
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Attention Deficit Hyperactivity Disorder
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Child Nutrition and Feeding Issues
- Neural dynamics and brain function
- Neurological disorders and treatments
- Child Development and Digital Technology
- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Diet and metabolism studies
- Behavioral and Psychological Studies
- Mental Health Treatment and Access
- EEG and Brain-Computer Interfaces
National Taiwan University Hospital
2016-2025
National Taiwan University
2014-2024
National Yang Ming Chiao Tung University
2017-2018
National Science and Technology Council
2012
Ontotext (Bulgaria)
2012
National Chung Hsing University
2005
Schizophrenia has been associated with abnormal task-related brain activation in sensory and motor regions as well social cognition network. Recently, two studies investigated temporal correlation between resting-state functional magnetic resonance imaging (R-fMRI) low-frequency oscillations (LFOs) schizophrenia but reported mixed results. This may be due to the different frequency bands used these studies. Here we utilized R-fMRI measure amplitude of fluctuations (ALFF) fractional ALFF...
Background Impaired executive function (EF) is suggested to be one of the core features in individuals with autism spectrum disorders (ASD); however, little known about whether extent worse EF ASD than typically developing (TD) controls age-dependent. We used age-stratified analysis reveal this issue. Method assessed 111 youths (aged 12.5 ± 2.8 years, male 94.6%) and 114 age-, sex-matched TD Digit Span four tasks Cambridge Neuropsychological Test Automated Battery (CANTAB): Spatial (SSP),...
Despite inconsistent results across studies, emerging evidence suggests that the microbial micro-environment may be associated with autism spectrum disorder (ASD). Geographical and cultural factors highly impact profiles, there is a shortage of data from East Asian populations. This study aimed to comprehensively characterize profiles in an sample explore whether gut microbiota contributes clinical symptoms, emotional/behavioral problems, GI symptoms ASD.We assessed 82 boys young men ASD 31...
Low frequency oscillations are essential in cognitive function impairment schizophrenia. While functional connectivity can reveal the synchronization between distant brain regions, regional abnormalities task-independent baseline activity less clear, especially specific bands. Here, we used a homogeneity (ReHo) method combined with resting-state magnetic resonance imaging to investigate low spontaneous neural three different bands (slow-5∶0.01–0.027 Hz; slow-4∶0.027–0.08 and typical band:...
Background An uneven neurocognitive profile is a hallmark of autism spectrum disorder (ASD). Studies focusing on the visual memory performance in ASD have shown controversial results. We investigated and sustained attention youths with typically developing (TD) youths. Method recruited 143 pairs (males 93.7%; mean age 13.1, s.d. 3.5 years) age- sex-matched TD The group consisted 67 autistic (autism) 76 Asperger's (AS) based DSM-IV criteria. They were assessed using Cambridge...
Abstract Based on our previous finding of a seven-miRNA (hsa-miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652) signature as potential biomarker for schizophrenia, this study aimed to examine if hospitalization could affect expressions these miRNAs. We compared their expression levels between acute state partial remission in people with schizophrenia ( n =48) using quantitative PCR method. Further, whether the blood brain show similar patterns, two miRNAs (hsa-miR-34a...
Autism spectrum disorder (ASD) is an early-onset neurodevelopmental with complex genetic underpinning in its etiology. Copy number variations (CNVs) as one of the factors associated ASD have been addressed recent genome-wide association studies (GWAS). However, significance CNV has not well investigated non-Caucasian population. To identify pathogenic CNVs responsible for Han Chinese, we performed a segment-based GWAS 335 cases and 1093 healthy controls using Affymetrix single nucleotide...
Patients with remitted psychosis face a dilemma between the wish to discontinue antipsychotics and risk of relapse. We test if an operationalized guided-dose-reduction algorithm can help reach lower effective dose without increased risks relapse.A 2-year open-label randomized prospective comparative cohort trial from Aug 2017 Sep 2022. history schizophrenia-related psychotic disorders under stable medications symptoms were eligible, 2:1 into guided reduction group (GDR) v. maintenance...
Automated tract-based analysis of diffusion MRI is an important tool for investigating tract integrity the cerebral white matter. Current template-based automatic analyses still lack a comprehensive list atlas and accurate registration method. In this study, (TBAA) was developed to meet demands. Seventy-six major matter tracts were reconstructed on high-quality spectrum imaging (DSI) template, advanced two-step strategy proposed by incorporating anatomical information gray from T1-weighted...
<title>Abstract</title> BACKGROUND Despite a high heritability of schizophrenia (SZ), only limited variance was attributed to gene loci or the polygenic risk score in genome-wide association studies (GWAS). Early-onset SZ, more homogeneous SZ subtype, may aid bridging genotype-phenotype gap and identification its hub genes is critical for early intervention clinical practice. We aimed examine expression (GeRS) patients from both multiplex simplex families identify early-onset perform...
The purpose of the present study was to examine motivation for contextual nature motivations social participation in cognitively able adolescents and adults with autism spectrum disorder, using self-determination theory as a theoretical framework.Fourteen Australians 16 Taiwanese (aged 16-45 years) Asperger's syndrome high functioning were asked carry device which prompted them seven times/day 7 days, record what they doing, whom, perceived difficulty reciprocity, reasons engaging situation,...
Prenatal and perinatal factors may increase the risk of autism spectrum disorder. However, little is known about whether unaffected siblings probands with disorder also share phenomenon prenatal/perinatal are related to clinical severity autistic symptoms. We compared frequency prenatal among 323 (mean age ± standard deviation, 10.7 3.5 years; males, 91.0%), 257 (11.7 4.5; 42.8%), 1504 typically developing controls (8.9 1.6 53.1%); investigated their effects on found that had more events...
Both neurocognitive deficits and schizophrenia are highly heritable. Genetic overlap between has been observed in both the general population clinical samples. This study aimed to examine if polygenic architecture of susceptibility modified performance patients. Schizophrenia risk scores (PRSs) were first derived from Psychiatric Genomics Consortium (PGC) on schizophrenia, then calculated our independent sample 1130 trios, who had PsychChip data part Families Taiwan project. Pseudocontrols...
The presence of attention-deficit/hyperactive disorder (ADHD) symptoms and impaired attention performance are commonly noted in individuals with autism spectrum (ASD). However, little is known about their unaffected siblings. This study aimed to investigate the ADHD-related traits siblings probands Asperger syndrome (AS), as well clinical correlates traits.
Although evidence suggests that the activity of anterior cingulate cortex involves social cognition, there are inconsistent findings regarding aberrant gray matter (GM) and scanty about altered cortical thickness white (WM) in individuals with autism spectrum disorder (ASD). Evidence supports association between genetic variants CNTNAP2 brain connectivity. This study investigated substructure its awareness deficits ASD typically-developing controls (TDC).We assessed 118 122 TDC MRI clinical...
The design goals of recently developed serious games are to improve attention, affective recognition, and social interactions among individuals with autism. However, most previous studies on used behavioral questionnaires evaluate their effectiveness. cognitive assessment autism after intervention or drug treatment has become important because it provides promising biomarkers assess improvement intervention. In this study, we a game-based interaction platform incorporating an eye-tracking...
Conceptualizing mental disorders as deviations from normative functioning provides a statistical perspective for understanding the individual heterogeneity underlying psychiatric disorders. To broaden of idiosyncrasy brain aging in schizophrenia, we introduced an imaging-derived age paradigm combined with modeling novel metrics. We constructed models based on GM, WM, and their combination (multimodality) features 482 normal participants. The normalized predicted difference (nPAD) was...
The diagnosis of autism spectrum disorder (ASD), involving multiple components clinical assessments, is challenging. Autism Diagnostic Observation Schedule-Generic (ADOS-G), one the standardized and validated instruments for ASD diagnostic evaluation, has been widely used in many countries. With preparation Mandarin version ADOS-G (Mandarin-ADOS-G), this study aims to examine its psychometric properties, including reliability validity.The sample included 554 individuals clinically diagnosed...