Shan Wan

ORCID: 0000-0002-3571-9942
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About
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Research Areas
  • Sepsis Diagnosis and Treatment
  • COVID-19 Clinical Research Studies
  • Digestive system and related health
  • Dermatological and Skeletal Disorders
  • Bone health and treatments
  • Antimicrobial Peptides and Activities
  • Coordination Chemistry and Organometallics
  • Chemical Reactions and Isotopes
  • Medicinal Plant Pharmacodynamics Research
  • Circular RNAs in diseases
  • Bacterial biofilms and quorum sensing
  • Reproductive System and Pregnancy
  • Cold Fusion and Nuclear Reactions
  • RNA Research and Splicing
  • SARS-CoV-2 and COVID-19 Research
  • Antibiotic Resistance in Bacteria
  • Extracellular vesicles in disease
  • Enterobacteriaceae and Cronobacter Research
  • Optimal Power Flow Distribution
  • Plant and Fungal Interactions Research
  • Biological and pharmacological studies of plants
  • Pregnancy and preeclampsia studies
  • Traditional Chinese Medicine Analysis
  • Plant Disease Management Techniques
  • Oral microbiology and periodontitis research

West China Medical Center of Sichuan University
2024

Soochow University
2021-2023

Nanjing University
2021-2022

Affiliated Hospital of Guizhou Medical University
2020-2021

Tsinghua University
2021

Guiyang Medical University
2018-2021

Luoyang Institute of Science and Technology
2015

Shandong Provincial QianFoShan Hospital
2012

Huazhong Agricultural University
2009

Tripler Army Medical Center
1984

Abstract The development of green and efficient deuteration methods is great significance for various fields such as organic synthesis, analytical chemistry, medicinal chemistry. Herein, we have developed a dehalogenative strategy using piezoelectric materials catalysts in solid‐phase system under ball‐milling conditions. This non‐spontaneous reaction induced by mechanical force. D 2 O can serve both deuterium source an electron donor the transformation, eliminating need additional...

10.1002/anie.202400645 article EN Angewandte Chemie International Edition 2024-04-30

The drug resistance rate of Acinetobacter baumannii increases year by year, and the drugs available for treatment carbapenem-resistant A. (CRAB) infection are extremely limited. baumannii, which forms biofilms, protects itself secreting substrates such as exopolysaccharides, allowing it to survive under adverse conditions increasing resistance. Antimicrobial peptides small molecular with broad-spectrum antibacterial activity immunomodulatory function. Previous studies have shown that...

10.3389/fmicb.2020.01532 article EN cc-by Frontiers in Microbiology 2020-08-11

Both sorafenib (SOR) and regorafenib (REG), which are structurally similar, can form drug–drug cocrystals with 5-fluorouracil (FU). However, while SOR-FU could be prepared easily by the slurry approach, elusive REG-FU not without seeds of SOR-FU. The influence fluoro substitution SOR on cocrystal formation is understood considering phase solubility diagrams (PSD) in methanol acetonitrile changes free energy lattice upon cocrystallization using experimental computational approaches. On basis...

10.1021/acs.cgd.1c00512 article EN Crystal Growth & Design 2021-09-07

In this study, we used a metagenomic approach to analyze microbial communities, antibiotic resistance gene diversity, and human pathogenic bacterium composition in two typical landfills China. Results showed that the phyla Proteobacteria, Bacteroidetes, Actinobacteria were predominant landfills, archaea fungi also detected. The genera Methanoculleus, Lysobacter, Pseudomonas predominantly present all samples. sul2, sul1, tetX, adeF four most abundant genes. Sixty-nine bacterial pathogens...

10.3390/d13060230 article EN cc-by Diversity 2021-05-24

Abstract Objectives This study aimed to explore clinical indexes for management of severe/critically ill patients with COVID‐19, influenza A H7N9, and H1N1 pneumonia by comparing hematological radiological characteristics. Methods Severe/critically were retrospectively enrolled. The demographic data, manifestations, parameters, characteristics compared. Results In this study, 16 cases 10 13 who met criteria included. Compared H7N9 groups had more chronic diseases (80% 92.3% vs. 25%, p <...

10.1002/jcla.24100 article EN cc-by-nc Journal of Clinical Laboratory Analysis 2021-11-11

Abstract The development of green and efficient deuteration methods is great significance for various fields such as organic synthesis, analytical chemistry, medicinal chemistry. Herein, we have developed a dehalogenative strategy using piezoelectric materials catalysts in solid‐phase system under ball‐milling conditions. This non‐spontaneous reaction induced by mechanical force. D 2 O can serve both deuterium source an electron donor the transformation, eliminating need additional...

10.1002/ange.202400645 article EN Angewandte Chemie 2024-04-30

Abstract Background: In follicular lymphoma (FL), histologic transformation to high-grade FL and diffuse large B-cell (DLBCL) is a critical adverse step in disease progression. Activation of the oncogene c-MYC tumor microenvironment remodeling account for A panel microRNA (miRNA) was downregulated transformed FL. Methods: Differentially expressed miRNAs were systematically analyzed compared eleven lymph nodes tissue samples from patients at different stages disease. Expression miR-7e-5p 46...

10.21203/rs.3.rs-38701/v2 preprint EN cc-by Research Square (Research Square) 2020-09-23

Objective To evaluate the differences of toxicities, therapeutic efficacy and immune function between induction chemotherapy followed by sinusoidal chrono-modulated infusion flat intermittent cisplatin(DDP)with intensity-modulated radiotherapy (IMRT) in patients with locoregionally advanced nasopharyngeal carcinoma (NPC). Methods Seventy biopsy- diagnosed stages Ⅲ ⅣB NPC (according to 2010 UICC staging system) were treated two-cycle before chemoradiotherapy Guizhou Cancer Hospital....

10.3760/cma.j.issn.0254-5098.2018.04.007 article EN Zhonghua fangshe yixue yu fanghu zazhi 2018-04-25

Abstract Background: In follicular lymphoma (FL), histologic transformation to high-grade FL and diffuse large B-cell (DLBCL) is a critical adverse step in disease progression. Activation of the oncogene c-MYC tumor microenvironment remodeling account for A panel microRNA (miRNA) was downregulated transformed FL. Methods: Differentially expressed miRNAs were systematically analyzed compared eleven lymph nodes tissue samples from patients at different stages disease. Expression miR-7e-5p 46...

10.21203/rs.3.rs-38701/v3 preprint EN cc-by Research Square (Research Square) 2020-10-26

Abstract Objectives This study aimed to explore useful clinical indexes for management of severe/critically ill patients with COVID-19, Influenza A H7N9 and H1N1 pneumonia by comparing hematological radiological characteristics between them. Methods Severe/critically confirmed diagnosis were retrospectively enrolled. The demographic data, manifestations, parameters, three groups compared. influenza was divided into two with/without patient death. Results In this study, 16 cases 10 (H7N9), 13...

10.21203/rs.3.rs-228013/v1 preprint EN cc-by Research Square (Research Square) 2021-02-12
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