A5020139977- Gyrotron and Vacuum Electronics Research
- Microwave Engineering and Waveguides
- Antimicrobial Peptides and Activities
- Pulsed Power Technology Applications
- Particle accelerators and beam dynamics
- Terahertz technology and applications
- Insect Utilization and Effects
- Electromagnetic Simulation and Numerical Methods
- Antibiotic Resistance in Bacteria
- Biochemical and Structural Characterization
- Radio Frequency Integrated Circuit Design
- Antifungal resistance and susceptibility
- Advanced Computational Techniques and Applications
- Insect Resistance and Genetics
- Chinese history and philosophy
- Invertebrate Immune Response Mechanisms
- Aluminum Alloy Microstructure Properties
- Protein Hydrolysis and Bioactive Peptides
- Landslides and related hazards
- Service-Oriented Architecture and Web Services
- Bacterial biofilms and quorum sensing
- Viral Infectious Diseases and Gene Expression in Insects
- Industrial Technology and Control Systems
- Metallurgy and Material Science
- Photonic and Optical Devices
North Sichuan Medical University
2025
University of Electronic Science and Technology of China
2015-2024
Guiyang Medical University
2012-2024
Hong Kong Baptist University
2022-2023
Kunming University
2007-2023
Affiliated Hospital of Guizhou Medical University
2023
Yunnan Normal University
2023
Southwest China Institute of Electronic Technology
2023
Guangxi Mangrove Research Center
2022
National Engineering Research Center of Electromagnetic Radiation Control Materials
2017
Housefly, Musca domestica, has a complicated immune system. However, its underlying operating mechanism remains elusive. Candida albicans is major pathogen affecting humans by causing deep infection fungous disease, but it non-symbiotic in houseflies. To investigate the C. process housefly, changes morphological and histological expression patterns of antimicrobial peptide were monitored to indicate insect's response fungal infection. The results showed that scattered brown spots comprising...
Introduction Bacterial infections have become serious threats to human health, and the excessive use of antibiotics has led emergence multidrug-resistant (MDR) bacteria. E. coli is a bacterial pathogen, which can cause severe infectious. Antimicrobial peptides are considered most promising alternative traditional antibiotics. Materials methods The minimum inhibitory concentration (MIC), bactericidal (MBC) hemolytic activity were determined by microdilution method. antimicrobial kinetics...
Candida albicans is a major fungal pathogen in humans. Novel antifungal agents are urgent demanded due to the challenges of resistance. Antimicrobial peptides critical components innate immune system against pathogenic microorganism infection. MAF-1A novel cationic antimicrobial peptide that comes from Musca domestica and effective C. albicans, but mechanism remains unclear. In this study, we performed transcriptomics analysis using RNA-seq technique under treatment MAF-1A. A total 5654...
The drug resistance rate of Acinetobacter baumannii increases year by year, and the drugs available for treatment carbapenem-resistant A. (CRAB) infection are extremely limited. baumannii, which forms biofilms, protects itself secreting substrates such as exopolysaccharides, allowing it to survive under adverse conditions increasing resistance. Antimicrobial peptides small molecular with broad-spectrum antibacterial activity immunomodulatory function. Previous studies have shown that...
The sine waveguide (SWG) is presented as a potential slow-wave structure (SWS) for the millimeter-wave (mm-wave) and terahertz (THz) traveling-wave tube (TWT) because of advantages wide bandwidth, natural electron beam tunnel, easy fabrication. In particular, this theoretical study indicates that transmission loss SWG far less than folded SWS, which widely employed in mm-wave THz TWT. Here, flat-roofed circuit working <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Candida albicans is associated with high mortality among immunocompromised patients. Resistance to and toxic side effects of antifungal drugs require the development alternative agents. AMP-17 a novel antimicrobial peptide derived from Musca domestica that exerts excellent against species. In this article, we discuss potential mechanism C. perspective affecting latter's cell external structure.Recombinant was prepared by prokaryotic expression system, its anti-C. activity detected...
Mao, Li MB; Tian, Jing Zhang, Wen Guo, Gan-Wen Du, Yao-Nan MM Author Information
Cryptococcus neoformans infections pose a significant global health threat. This study introduces mesoricin, novel dual-domain antimicrobial peptide (AMP) scaffold derived from Mesorhizobium sp. identified using an in silico quantitative antifungal activity index (AFI). The structure comprises α-helix domain, which disrupts microbial membranes but exhibits highly hemolytic activity, and β-sheet targets intracellular energy metabolism resilient pathways. Rational design through domain removal...
This article reports a slow-wave structure (SWS) working at 1 THz which can be fabricated through nano-computer numerical control (nano-CNC) technology for the first time. First, deformed quasi sine waveguide (D-QSWG) SWS has been designed and simulated in this article. To reduce metal loss of input output waveguide, coupler transit to over mode rectangular designed. The simulation result shows that waveguides with have lower than WR1 waveguide. fabricate D-QSWG SWS, tungsten steel endmills...
Acinetobacter baumannii has become a major difficulty in the treatment of bacteria-associated infection. The previously reported antimicrobial peptide Cec4 exhibited good and stable activity against A. vitro, but mechanisms effects vivo are elusive.The on bacterial membrane permeability, potential reactive oxygen species were measured. cell localization peptides was studied by fluorescence labelling. ability bacteria to develop resistance continuous induction, transcriptome difference...
A novel slow-wave structure (SWS), named ridge-loaded sine waveguide (RLSWG), has been proposed to develop the wideband high-power terahertz traveling-wave tube (TWT). The characteristics of RLSWG SWS, including dispersion properties and interaction impedance, are analyzed by using 3-D electromagnetic simulation software Ansoft high frequency simulator (HFSS). From our calculation, average impedance SWS at 0.22 THz is 42.2% higher than conventional SWG SWS. Meanwhile, results demonstrate...
The biofilm formation of C. albicans represents a major virulence factor during candidiasis. Biofilm-mediated drug resistance has necessitated the search for new antifungal treatment strategy. In our previous study, novel antimicrobial peptide named AMP-17 derived from Musca domestica was confirmed to have significant activity and suppress hyphal growth greatly in albicans. current work, we aimed investigate antibiofilm property explore underlying mechanism. An susceptibility assay showed...
A case of Acinetobacter baumannii (A. baumannii), known as gram-negative bacteria, causes a range nosocomial infections. Due to the continuous detection multi-drug resistant A. in clinic, there is an urgent need find alternative therapies, including broad-spectrum antibacterial peptides (AMP). Recently it has been found that peptide Cec4 good activity against baumannii, but mechanism remains elusive.The basic structure was analyzed by circular dichroism (CD) spectroscopy, and potential...
Antibiotic resistance in Acinetobacter baumannii is on the rise around world, highlighting urgent need for novel antimicrobial drugs. Antimicrobial peptides (AMPs) contribute to effective protection against infections by pathogens, making them most promising options next-generation antibiotics. Here, we report two designed, cationic, antimicrobial-derived peptides: Mt6, and its dextroisomer D-Mt6, belonging analogs of MAF-1, which isolated from instar larvae houseflies. Both Mt6 D-Mt6 have a...
Antibacterial hydrogels, as novel antibacterial materials with inherent or exogenous activity, can be used for local use, controlled drug release, stimulus-responsive activation, synergistic therapy, realizing its translational applications in different medical fields.
It has been reported that there are more than ten antimicrobial peptides (AMPs) belonging to the cecropin family in Musca domestica; however, few of them have identified, and functions other molecules poorly understood.Sequences M. domestica genes were cloned from cDNA template, which was reverse-transcribed total mRNA isolated third-instar larvae challenged with pathogens. Sequence analysis performed using DNAMAN comprehensive software, a molecular phylogenetic tree constructed...
Antifungal peptides are effective, biocompatible, and biodegradable, thus, they promising to be the next generation of drugs for treating infections caused by fungi. The identification processes highly active peptides, however, still time-consuming labor-intensive. Quantitative structure-activity relationships (QSARs) have dramatically facilitated discovery many bioactive drug molecules without a priori knowledge. In this study, we established an effective QSAR protocol screening antifungal...
Cryptococcus neoformans is a common human fungal pathogen in immunocompromised people, as well prevalent cause of meningitis HIV-infected individuals. With the emergence clinical resistance and shortage antifungal drugs, it urgent to discover novel agents. AMP-17, antimicrobial peptide from Musca domestica, has activity against C. neoformans. However, its anti-biofilm activities remain unclear. Thus, this study aimed evaluate AMP-17 planktonic cells biofilms neoformans.The minimum inhibitory...
The electron optical systems (EOS) play a vital role in vacuum devices (VED). This letter reported the design and experiments of sheet EOS for 1.03 THz traveling wave tube (TWT). A high-current-density beam (SEB) gun generating up to 20.3-mA at 22.4-kV is designed, based on requirements this TWT. Due very high operating frequency, more than 1 THz, miniature tunnel waist with dimension 0.05 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
We previously identified the six-transmembrane epithelial antigen of prostate (STEAP) 4 as a novel plasma membrane protein that is up-regulated in obese patients and may play significant role development human obesity. In this study, STEAP4-specific antibody was used to characterize biological functions STEAP4 adipocytes. Cell viability assays (Trypan Blue exclusion), CCK-8 cell cycle analysis showed inhibited pre-adipocyte proliferation. Morphological observations by electron microscopy...