A5011089168- Microbial Natural Products and Biosynthesis
- Escherichia coli research studies
- Bacterial Genetics and Biotechnology
- Marine Sponges and Natural Products
- Synthesis and Biological Activity
- Chemical Synthesis and Analysis
- Ginger and Zingiberaceae research
- Virus-based gene therapy research
- Cancer Research and Treatments
- Carbohydrate Chemistry and Synthesis
- Graphene and Nanomaterials Applications
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Genomics, phytochemicals, and oxidative stress
Seoul National University
2019-2022
Chonnam National University
2014-2020
Chonnam National University Hwasun Hospital
2020
Chonnam National University Hospital
2015-2019
Streptomyces sp. GET02.ST and Achromobacter GET02.AC were isolated together from the gut of wharf roach, Ligia exotica, inhabiting intertidal zone west coast Korea. The co-cultivation these two strains significantly induced production new metabolites, ligiamycins A (1) B (2), which barely detected in single culture GET02.ST. planar structures (2) elucidated as decalins coupled with amino-maleimides by analysis various spectroscopic data, including nuclear magnetic resonance (NMR),...
The cyclic depsipeptides ohmyungsamycin (OMS) A (1) and B (2), isolated from the marine-derived Streptomyces sp. SNJ042, contain two non-proteinogenic amino acid residues, β-hydroxy-l-phenylalanine (β-hydroxy-l-Phe) 4-methoxy-l-tryptophan (4-methoxy-l-Trp). Draft genome sequencing of SNJ042 revealed OMS biosynthetic gene cluster consisting a nonribosomal peptide synthetase (NRPS) three genes for modification. By inactivation analysis accumulated products, we found that OhmL, encoding P450...
Significance Ler [locus of e nterocyte ffacement (LEE)-encoded regulator], encoded by the first gene LEE1 operon in enteropathogenic Escherichia coli (EPEC), represses its own transcription driven two promoters separated 10 bp. We found that does this repression through a DNA loop 16 helical turns, which RNA polymerase is trapped as open promoter complex, although complex should be most readily transformed into productive initiation complex.
Aucklandia lappa Decne., known as “Mok-hyang” in Korea, has been used for the alleviation of abdominal pain, vomiting, diarrhea, and stress gastric ulcers traditional oriental medicine. We investigated anti-inflammatory antioxidative effects ethanol extract Decne. (ALDE) lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. ALDE significantly inhibited LPS-induced nitric oxide (NO) production reduced inducible synthase (iNOS) expression The other proinflammatory mediators, including COX-2,...
Spinal cord injuries (SCI) are well thought to be a crucial issue that roots various side effects for patient during their entire lifetime. Although therapeutical methods resolve the SCI limited, stem cell therapy is determined resolving factor since it possesses ability induce neurogenic differentiation and paracrine effect. However, cells difficult inject directly into lesion, so they must carefully guided through spinal canal. Therefore, superparamagnetic iron oxide nanoparticles (SPIONs)...