A5100772099- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Plant Disease Resistance and Genetics
- Epigenetics and DNA Methylation
- Plant Pathogens and Fungal Diseases
- Genomics and Phylogenetic Studies
- Genetic Syndromes and Imprinting
- Genetics and Neurodevelopmental Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Plant-Microbe Interactions and Immunity
- Genetics and Plant Breeding
- Neuroblastoma Research and Treatments
- S100 Proteins and Annexins
- RNA modifications and cancer
- Power Systems and Renewable Energy
- Microbial Natural Products and Biosynthesis
- Virus-based gene therapy research
- bioluminescence and chemiluminescence research
- Genomics and Chromatin Dynamics
- Acute Kidney Injury Research
- Electrocatalysts for Energy Conversion
- Mollusks and Parasites Studies
- Allelopathy and phytotoxic interactions
- Geoscience and Mining Technology
- Nuclear Structure and Function
Tianjin Medical University
2019-2024
Shenzhen University
2017-2024
Shenzhen Second People's Hospital
2022-2024
Second Hospital of Tianjin Medical University
2022-2023
Shenzhen University Health Science Center
2022
Lingnan Normal University
2018
Shenyang Agricultural University
2012-2016
Institute of Microbiology
2005-2015
Chinese Academy of Sciences
2005-2015
Microbiology Institute of Shaanxi
2005
Pharmacological induction of NRF2 restores redox homeostasis and slows cystogenesis in mouse models polycystic kidney disease.
Abstract Renal tubular epithelial cells (TECs) can initiate an adaptive response to completely recover from mild acute kidney injury (AKI), whereas severe often leads persistence of maladaptive repair and progression fibrosis. Through profiling active DNA regulatory elements by ATAC-seq, we reveal widespread, dynamic changes in the chromatin accessibility TECs after ischemia–reperfusion injury. We show that injury-specific domains become accessible prior gene activation, creating poised...
P-TEFb activation by cAMP-PKA signaling promotes cystogenic gene transcription elongation and disease progression in ADPKD.
Functional crosstalk between histone modifications and chromatin remodeling has emerged as a key regulatory mode of transcriptional control during cell fate decisions, but the underlying mechanisms are not fully understood. Here we discover an HRP2-DPF3a-BAF epigenetic pathway that coordinates methylated H3 lysine 36 (H3K36me) ATP-dependent to regulate dynamics gene transcription myogenic differentiation. Using siRNA screening targeting modifiers, identify hepatoma-derived growth...
An impaired blood–retinal barrier (BRB) leads to diabetic macular edema (DME), which is a major complication of Diabetic retinopathy (DR). Mediators such as inflammation cause BRB breakdown. However, the explicit mechanism its disruption largely unknown. In this study, we identified tumor necrosis factor ligand-related molecule 1A (TL1A) crucial protect retinal endothelial cells integrity in DR. By providing both human and mouse data, show that TL1A significantly decreased retinas DME...
Formation of biomolecular condensates by phase separation has recently emerged as a new principle for regulating gene expression in response to extracellular signaling. However, the molecular mechanisms underlying coupling signal transduction and activation through condensate formation, how dysregulation these contributes disease progression, remain elusive. Here, authors report that CREB-regulated transcription coactivator 2 (CRTC2) translocates nucleus forms phase-separated upon cAMP They...
Understanding the sequence diversity of rice blast resistance genes is important for breeding new resistant cultivars against fungus Magnaporthe oryzae. In this study, we selected 24 with different genetic backgrounds to study allelic Piz-t, Pita and Pik. For a total 17 types were found within cultivars. Blast inoculations showed that most mutations can affect function gene. Pita, except difference at 918th amino acid, majority 21 detected among Inoculations isolates carrying Avr-Pita...
S-Nitrosylation is a reversible covalent post-translational modification. Under physiological conditions, S-nitrosylation plays dynamic role in wide range of biological processes by regulating the function substrate proteins. Like other modifications, can affect protein conformation, activity, localization, aggregation, and interactions. Aberrant lead to misfolding, mitochondrial fragmentation, synaptic damage, autophagy. Mitochondria are essential organelles energy production, metabolite...
Genome-wide mapping of transcription factor (TF) binding sites is essential to identify a TF's direct target genes in kidney development and diseases. However, due the cellular complexity limited numbers given cell type, it has been challenging determine TF vivo. cAMP response element-binding protein (CREB) phosphorylated hyperactive autosomal dominant polycystic disease (ADPKD). We focus on CREB as an example profile genomic loci bound by its using low specific cells.Cleavage under targets...
The use of human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) as vehicles to deliver antinociceptive galanin (GAL) molecules into pain-processing centers represents a novel cell therapy strategy for pain management. Here, an hTERT-BMSCs/Tet-on/GAL line was constructed using single Tet-on-inducible lentivirus system, and subsequent experiments demonstrated that the secretion rat GAL from switched on off under control inducer in...
Abstract Background Dexamethasone (Dexa) and potassium canrenoate (Cane) modulate nociceptive behavior via glucocorticoid receptor (GR) mineralocorticoid (MR) by two mechanisms (genomic nongenomic pathways). This study was designed to investigate the Dexa‐ or Cane‐mediated genomic effects on mechanical nociception inflammation‐induced changes in interleukin‐6 (IL‐6) mediated signaling pathway rats. Methods Freund's complete adjuvant (FCA) used trigger an inflammation of right hind paw male...