A5037910277- Respiratory viral infections research
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Pneumonia and Respiratory Infections
- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Zoonotic diseases and public health
- Healthcare cost, quality, practices
- Infection Control and Ventilation
- Inhalation and Respiratory Drug Delivery
- Health and Medical Research Impacts
- Aquaculture disease management and microbiota
- Species Distribution and Climate Change
- Receptor Mechanisms and Signaling
- Climate Change and Health Impacts
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Health Policy Implementation Science
- Insect and Arachnid Ecology and Behavior
National Institute for Biological Standards and Control
2021-2022
Imperial College London
2007-2016
Cyprus Institute
2013-2016
Climate change can influence the transmission of vector-borne diseases (VBDs) through altering habitat suitability insect vectors. Here we present global climate model simulations and evaluate associated uncertainties in view main meteorological factors that may affect distribution Asian tiger mosquito (Aedes albopictus), which transmit pathogens cause chikungunya, dengue fever, yellow fever various encephalitides. Using a general circulation at 50 km horizontal resolution to simulate...
It is well documented that the density of Plasmodium in its vertebrate host modulates physiological response induced; this turn regulates parasite survival and transmission. less clear mosquito transmission important pathogen. Numerous studies have described conversion rates from one life stage to next within mosquito, yet few considered these might vary with density. Here we establish infections defined numbers rodent malaria berghei examine how at each development (gametocytes; ookinetes;...
Background Mosquito-borne viral diseases cause significant burden in much of the developing world. Although host-virus interactions have been studied extensively vertebrate host, little is known about mosquito responses to infection. In contrast mosquitoes Aedes and Culex genera, Anopheles gambiae, principal vector human malaria, naturally transmits very few arboviruses, most important which O'nyong-nyong virus (ONNV). Here we investigated A. gambiae immune response systemic ONNV infection...
The Asian tiger mosquito, Aedes albopictus, is a highly invasive vector species. It proven of dengue and chikungunya viruses, with the potential to host further 24 arboviruses. has recently expanded its geographical range, threatening many countries in Middle East, Mediterranean, Europe North America. Here, we investigate theoretical limitations range expansion by developing an environmentally-driven mathematical model population dynamics. We focus on temperate strain Ae. albopictus compile...
Complex in vitro respiratory models, including air-liquid interface (ALI) transwell cultures and airway organoids, have emerged as promising tools for studying human virus infections. These models address several limitations of conventional two-dimensional cell line animal models. However, the lack standardized protocols application these infection studies limits possibilities comparing results across different research groups. Therefore, we applied a collaborative approach to harmonize...
The haemagglutination inhibition assay (HAI) and the virus microneutralisation (MN) are long-established methods for quantifying antibodies against influenza viruses. Despite their widespread use, both assays require standardisation to improve inter-laboratory agreement in testing. FLUCOP consortium aims develop a toolbox of standardised serology seasonal influenza. Building upon previous collaborative studies harmonise HAI, this study carried out head-to-head comparison harmonised HAI MN...
Current vaccination strategies against influenza focus on generating an antibody response the viral haemagglutination surface protein, however there is increasing interest in neuraminidase (NA) as a target for vaccine development. A critical tool development of vaccines that NA or include component available validated serology assays quantifying anti-NA antibodies. Additionally have role defining correlates protection and licensure. Standardisation these important consistent accurate...
Introduction External Quality Assessment (EQA) schemes are designed to provide a snapshot of laboratory proficiency, identifying issues and providing feedback improve performance inter-laboratory agreement in testing. Currently there no international EQA for seasonal influenza serology Here we present feasibility study conducting an scheme methods. Methods We invited participant laboratories from industry, contract research organizations (CROs), academia public health institutions who...
The hemagglutination inhibition (HAI) assay is the most commonly used serology to detect antibodies from influenza vaccination or virus infection. This has been for decades but requires improved standardization of procedures provide meaningful data.
Climate change is expected to impact widely upon human health, including changes in the geographic distribution of vectors that carry severe diseases such as malaria, Dengue fever, Chikungunya, and...