Natalie I Mazur
A5029736963- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Parvovirus B19 Infection Studies
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Immune responses and vaccinations
- Health and Medical Research Impacts
- Viral Infections and Vectors
- Healthcare cost, quality, practices
- Adolescent and Pediatric Healthcare
- Global Maternal and Child Health
- Congenital Heart Disease Studies
- COVID-19 Impact on Reproduction
- Reproductive Health and Technologies
- Ethics in Clinical Research
- Pediatric health and respiratory diseases
- SARS-CoV-2 detection and testing
- Infant Health and Development
- Virology and Viral Diseases
- Ovarian function and disorders
University Medical Center Utrecht
2015-2025
Wilhelmina Children's Hospital
2015-2025
St. Antonius Ziekenhuis
2023
Lurie Children's Hospital
2019
Northwestern University
2019
University of Washington
2018
University of Michigan–Ann Arbor
2018
Respiratory and Meningeal Pathogens Research Unit
2016
University of the Witwatersrand
2016
Transplacental respiratory syncytial virus (RSV) antibody transfer has been characterized, but little is known about the protective effect of breast milk RSV-specific antibodies. Serum antibodies against prefusion RSV fusion protein (pre-F) exhibit high neutralizing activity. We investigate protection pre-F acute infection (ARI). Breast at 1, 3, and 6 months postpartum midnasal swabs during infant illness episodes were collected in mother–infant pairs Nepal. One hundred seventy-four infants...
Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% mortality occurring in low- and lower middle-income countries. At least half RSV-related deaths are estimated to occur the community, but clinical characteristics this group children remain poorly characterized.The RSV Global Online Mortality Database (RSV GOLD), global registry under-5 who have died illness, describes dying through data sharing. GOLD acts as collaborative platform for deaths, including...
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI), hospitalisation, and mortality in infants young children, with the highest burden severe disease low-income middle-income countries (LMICs).1Li Y Wang X Blau DM et al.Global, regional, national estimates acute infections due to children younger than 5 years 2019: systematic analysis.Lancet. 2022; 399: 2047-2064Summary Full Text PDF PubMed Google Scholar The predominant hospitalisation occurs...
Molecular diagnostics enable sensitive detection of respiratory viruses, but their clinical significance remains unclear in pediatric lower tract infection (LRTI). We aimed to determine whether viral coinfections increased life-threatening disease a large cohort.Molecular testing was performed for viruses nasopharyngeal aspirates collected from children aged <5 years within 24 hours hospital admission during sentinel surveillance severe acute illness (SARI) hospitalization conducted South...
<title>Abstract</title> Intramuscular monoclonal antibodies (mAbs) can prevent respiratory infections but are costly and not globally available. The development of intranasal mAbs offers a promising cost-reducing non-invasive alternative to systemic administration, though clinical evidence is lacking. Intranasal palivizumab prevented syncytial virus (RSV) infection in mice healthy infants. This proof-of-concept study evaluates efficacy RSV infection. In this randomized, double-blind,...
Global health clinical research is commonly led by high-income countries (HICs) as low- and middle-income (LMICs) face barriers to participate, including lack of financial human capacity environment. Respiratory syncytial virus (RSV) vaccine development also HICs, while LMICs carry the burden life-threatening disease. Representative trials strengthening in are needed ensure global access equity. This study aims transfer an RSV neutralisation assay, which uses live cells with inherent high...
Respiratory syncytial virus (RSV) is a major cause of mortality in children younger than 5 years worldwide. Systematic reviews have shown that Down syndrome (DS) an independent risk factor for severe RSV infection. We aimed to describe demographic and clinical characteristics with DS who died
Patient-level data on life-threatening respiratory syncytial virus (RSV) infection in children low-income and lower-middle-income countries (LMICs) are scarce, this scarcity might limit demand for RSV interventions LMICs who rely support from Gavi, the Vaccine Alliance. We aimed to describe characteristics of RSV-positive younger than 2 years were admitted paediatric intensive care units (PICUs) with extended severe acute (eSARI) Gavi-eligible countries.
According to the World Health Organization, global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial occur at higher rates in low- and lower-middle-income countries (LMICs) than high-income (HICs). Current RSV estimates largely based on community-acquired infection. We aimed characterize children with RSV-related mortality understand potential impact immunization strategies.RSV GOLD a registry younger 5 years who died laboratory-confirmed...
BackgroundMucosal administration of monoclonal antibodies (mAbs) against respiratory pathogens is a promising alternative for systemic because lower doses are required protection. Clinical development mucosal mAbs highly active field yet clinical proof-of-concept lacking.MethodsIn this investigator-initiated, double-blind, randomized placebo-controlled trial, we evaluated intranasal palivizumab the prevention RSV infection in preterm infants (Dutch Trial Register NTR7378 and NTR7403). We 1:1...
The key correlate of protection respiratory syncytial virus (RSV) vaccines and monoclonal antibodies (mAb) is neutralization, measured using sera obtained through venipuncture. Dried blood with a finger prick can simplify acquisition, processing, storage, transport in trials, thereby reduce costs. In this study we validate an assay to measure RSV neutralization dried capillary blood.
Abstract Background Respiratory syncytial virus (RSV) infection is an important cause of hospitalization and death in young children. The majority deaths (99%) occur low- lower-middle-income countries (LMICs). Vaccines against RSV are underway. To obtain access to interventions, LMICs depend on support from Gavi, the Vaccine Alliance. identify future vaccine target populations, information children with severe required. However, there a lack individual patient-level clinical data instances...
Influenza virus infection is an important cause of under-five mortality. Maternal vaccination protects children younger than 3 months age from influenza infection. However, it unknown to what extent paediatric influenza-related mortality may be prevented by a maternal vaccine since global age-stratified data are lacking.We invited clinicians and researchers share clinical demographic characteristics 5 years who died with laboratory-confirmed between January 1, 1995 March 31, 2020. We...
BACKGROUND Respiratory syncytial virus (RSV) infection is an important cause of hospitalization and death in young children. The majority deaths (99%) occur low- lower-middle-income countries (LMICs). Vaccines against RSV are underway. To obtain access to interventions, LMICs depend on support from Gavi, the Vaccine Alliance. identify future vaccine target populations, information children with severe required. However, there a lack individual patient-level clinical data instances...
Abstract The key correlate of protection respiratory syncytial virus (RSV) vaccines and monoclonal antibodies (mAb) is neutralization, measured using sera obtained through venipuncture. Dried blood with a finger prick can simplify acquisition, processing, storage, transport in trials, thereby reduce costs. In this study we aim to validate low-tech assay measure RSV neutralization dried capillary blood. Recovery mAb from (volumetric absorptive microsampling) was used the elution method...