A5015563293- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Mechanical Circulatory Support Devices
- Asthma and respiratory diseases
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Amsterdam University Medical Centers
2020-2024
University of Amsterdam
2022-2024
Tergooi
2024
Emma Kinderziekenhuis
2020-2024
Children's Hospital of Richmond at VCU
2020
Virginia Commonwealth University
2020
Amsterdam UMC Location University of Amsterdam
2020
Respiratory syncytial virus (RSV) bronchiolitis causes substantial morbidity and mortality in young children, but insight into the burden of RSV on pediatric intensive care units (PICUs) is limited. We aimed to determine PICUs Netherlands. Therefore, we identified all children ≤ 24 months age with between 2003 2016 from a nationwide PICU registry. Subsequently manually checked their patient records for correct diagnosis collected characteristics, additional clinical data, respiratory support...
Mucus obstruction is a key feature of many inflammatory airway diseases. Neutrophil extracellular traps (NETs) are released upon neutrophil stimulation and consist chromatin networks studded with cytotoxic proteins. When in the airways, these NETs can become part mucus. We hypothesized that DNA and/or oxidative stress (e.g., by release reactive oxygen species myeloperoxidase during formation airways) would increase mucus viscoelasticity. collected human from endotracheal tubes healthy...
Influenza virus infection is an important cause of under-five mortality. Maternal vaccination protects children younger than 3 months age from influenza infection. However, it unknown to what extent paediatric influenza-related mortality may be prevented by a maternal vaccine since global age-stratified data are lacking.We invited clinicians and researchers share clinical demographic characteristics 5 years who died with laboratory-confirmed between January 1, 1995 March 31, 2020. We...
High flow nasal cannula (HFNC) therapy is a form of respiratory support used in children with bronchiolitis. A national guideline for the use HFNC was published The Netherlands 2020. We studied implementation and this guideline.
<h3>BACKGROUND:</h3> Intravenous formulations of epoprostenol are frequently delivered via nebulizer to treat pulmonary hypertension in acutely ill patients. Although their efficacy as vasodilators has been shown be comparable inhaled nitric oxide, the local effects these within airways have not determined. We hypothesized that alkaline diluents compounds would lead increased airway epithelial cell death and ciliary cessation. <h3>METHODS:</h3> Human bronchial cells were exposed glycine...
Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) causes a major burden of disease. The host response in RSV-LRTI is characterized by airway epithelial injury, inflammation and neutrophil influx, with the formation extracellular traps (NETs). However, precise role NETs pathophysiology remains to be elucidated. Here, we used well-differentiated human cultures (HAE) pediatric adult donor study whether cause injury setting RSV infection. exposure uninfected RSV-infected...
<b>Introduction:</b> Mucus obstruction is a key feature of many inflammatory airway diseases. Neutrophil extracellular traps (NETs), which are networks, primarily composed DNA from neutrophil activation, may affect mucus viscoelasticity thereby contributing to obstruction. We evaluated the effects NETs on rheologic properties and structure. <b>Methods:</b> Normal human was collected endotracheal tubes patients admitted for elective surgery. were derived isolated neutrophils co-incubated with...