A5013653265- Single-cell and spatial transcriptomics
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genetics, Aging, and Longevity in Model Organisms
- Pickering emulsions and particle stabilization
- SARS-CoV-2 and COVID-19 Research
- Peptidase Inhibition and Analysis
- Plant Molecular Biology Research
- Immune cells in cancer
- COVID-19 epidemiological studies
- Cryptography and Data Security
- Surface Modification and Superhydrophobicity
- Viral Infections and Outbreaks Research
- Advanced Photocatalysis Techniques
- RNA and protein synthesis mechanisms
- Advanced Steganography and Watermarking Techniques
- Respiratory viral infections research
- Infection Control and Ventilation
- Plant Reproductive Biology
- Nanocluster Synthesis and Applications
- Enhanced Oil Recovery Techniques
- Electrohydrodynamics and Fluid Dynamics
- Petroleum Processing and Analysis
- MicroRNA in disease regulation
Harbin Medical University
2022-2024
Northwest University
2024
China University of Petroleum, Beijing
2024
Northwestern Polytechnical University
2010
Discovering the biological basis of aging is one greatest remaining challenges for biomedical field. Work on biology has discovered a range interventions and pathways that control rate. Thus, we developed AgingBank (http://bio-bigdata.hrbmu.edu.cn/AgingBank) which was manually curated comprehensive database high-throughput analysis platform provided experimentally supported multi-omics data relevant to in multiple species. contained 3771 verified aging-related entries from studies across...
Interaction between tumor cells and immune determined highly heterogeneous microenvironments across patients, leading to substantial variation in clinical benefits from immunotherapy. Somatic gene mutations were found not only elicit adaptive immunity but also influence the composition of microenvironment various processes antitumor immunity. However, due an incomplete view associations immunophenotypes, how shape further determine benefit immunotherapy is still unclear. To address this, we...
Abstract Aerosol-transmitted viruses possess strong infectivity and can spread over long distances, earning the difficult-to-control title. They cause various human diseases pose serious threats to health. Mutations increase transmissibility virulence of strains, reducing protection provided by vaccines weakening efficacy antiviral drugs. In this study, we established a manually curated database (termed AVM) store information on aerosol-transmitted viral mutations (VMs). The current version...
This study extensively investigates the influence of different pyrolysis temperatures and organic matter contents on fluid flow heat transfer properties in oil shale samples. Utilizing CT images to generate three-dimensional digital rock, coupled simulations CO2 were conducted, analyzing parameters such as velocity fields, permeability, temperature average temperatures, coefficients. The results reveal that, for relatively homogeneous samples, permeability exhibits a monotonous increase with...
Spatial transcriptomics sequencing technology deepens our understanding of the diversity cell behaviors, fates and states within complex tissue, which is often determined by fine-tuning regulatory network functional activities. Therefore, characterizing activity tissue space helpful for revealing features that drive spatial heterogeneity, biological processes. Here, we describe a database, SPathDB (http://bio-bigdata.hrbmu.edu.cn/SPathDB/), aims to dissect pathway-mediated multidimensional...
Unrestrained cellular growth and immune escape of a tumor are associated with the incidental errors genome transcriptome. Advances in next-generation sequencing have identified thousands genomic transcriptomic aberrations that generate variant peptides assemble hidden proteome, further expanding immunopeptidome. Emerging technologies number computational methods estimated abundance infiltration from bulk transcriptome advanced our understanding microenvironments. Here, we will characterize...
Recently, many studies have shown that lncRNA can mediate the regulation of TF-gene in drug sensitivity. However, there is still a lack systematic identification lncRNA-TF-gene regulatory triplets for In this study, we propose novel analytic approach to systematically identify related sensitivity by integrating transcriptome data and data. Totally, 1570 sensitivity-related were identified, 16 307 relationships formed between drugs triplets. Then, comprehensive characterization was performed....
Abstract Systematic investigation of tumor-infiltrating immune (TII) cells is important to the development immunotherapies, and clinical response prediction in cancers. There exists complex transcriptional regulation within TII cells, different cell types display specific patterns. To dissect we first integrated gene expression profiles from single-cell datasets, proposed a computational pipeline identify type-specific transcription factor (TF) mediated activity modules (TF-AIMs). Our...
<title>Abstract</title> Background: The decline in organ function due to aging significantly impacts the health and quality of life elderly. Assessing delaying has become a major societal concern. Previous studies have largely focused on differences between young old, often overlooking complexity gradual nature aging. Methods: We annotated trajectories 16 organs reveal functional specificity identify organ-specific trend genes. Through inter-organ correlation analysis, we identified set...
Cancer is a highly heterogeneous disease, and different individuals of the same cancer type can display therapeutic effects prognosis. Genetic variation long non-coding RNA key factor driving tumor development, plays an important role in genetic biological heterogeneity. Therefore, it great significance to identify lncRNA as region explain its function tumors for revealing pathogenesis cancer. In this study, we developed integrated method Personalized Functional Driver lncRNAs (PFD-lncRNAs)...
Abstract Aerosol-transmitted viruses, with aerosol particles floating in the air to long distances, have characteristics of strong infectivity and wide spread that is difficult control. They cause various human diseases, posing a huge threat health. Some mutations can increase transmissibility virulence strain, which reduce protection vaccines weaken efficacy antiviral drugs. Here, we established manually curated database, AVM, store this information. The current version AVM contains total...
Public key cryptography system is not only successful in protecting the confidentiality of information transmission, but also a good solution to management issues. However, almost all knapsack-type public has been proven unsafe. This paper analyzed and improved an easy knapsack problem based on fast public-key cryptographic algorithm. An algorithm proposed due high density backpack, so that it can resist low-density subset attacks. Analysis shows that: In premise same efficiency encryption...