A5036226748- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Colorectal Cancer Screening and Detection
- Urinary Bladder and Prostate Research
- Cancer, Lipids, and Metabolism
- Advanced Radiotherapy Techniques
- Molecular Biology Techniques and Applications
- Estrogen and related hormone effects
- Statistical Methods in Clinical Trials
- Urological Disorders and Treatments
- Hepatitis B Virus Studies
- Renal cell carcinoma treatment
- Clinical practice guidelines implementation
- Sperm and Testicular Function
- Glutathione Transferases and Polymorphisms
- Cervical Cancer and HPV Research
- Urinary Tract Infections Management
- Urinary and Genital Oncology Studies
- COVID-19 Clinical Research Studies
- Sexual Differentiation and Disorders
- Cancer-related Molecular Pathways
- Radiation Therapy and Dosimetry
Kurosawa Hospital
2019-2025
Saiseikai Central Hospital
2012-2025
RIKEN Center for Integrative Medical Sciences
2024
Osaka University
2024
Kitasato University
2024
Gunma University
2013-2023
Gumma Paz College
2023
University of Toyama
2020
Gunma University Hospital
1997-2018
Suzuki (Japan)
2016-2018
Genistein is a major component of soybean isoflavone and has multiple functions resulting in antitumor effects. Prostate cancer 1 the targets for preventive role genistein. We examined effect genistein on human prostate (LNCaP PC-3) cells. Proliferation both cell lines was inhibited by treatment dose-dependent manner. To obtain gene expression profile LNCaP cells, we performed cDNA microarray analysis. The many genes, including apoptosis inhibitor (survivin), DNA topoisomerase II, division...
Prostate cancer epidemiology has been marked overall by a downward risk migration over time. However, in some populations, both the United States and abroad, many men are still diagnosed with high-risk and/or advanced disease. Primary androgen deprivation therapy (PADT) is frequently offered to these patients, disease prediction not well-established this context. We compared features between large registries from Japan, aimed build validate model applicable PADT patients.Data were analyzed...
BACKGROUND It is well-known that the incidence of benign prostatic hyperplasia (BPH) increases with aging. The age-dependent changes in ratio serum sex steroid concentrations may play a role BPH development. To clarify relationship between tissue these steroids and age, we established precise method simultaneous quantitative analysis for used this to investigate three major (testosterone, dihydrotestosterone, estradiol) human prostate. METHODS methodology was using castrated rat tissue,...
Active surveillance (AS) is one potential solution to avoiding the overtreatment of favorable prostate cancer. By handling AS strategy more safely, tumor aggressiveness may be evaluated accurately. The aim present study was evaluate predictive impact baseline prostate-specific antigen (PSA) isoform [-2]proPSA (p2PSA)-related indices on pathological reclassification at 1 year during an program.Between 2002 and 2003, 134 males diagnosed with low-risk cancer were registered in Japanese...
ABSTRACT Objective In this study, we compared the prostate health index (PHI) and Prostate Imaging Reporting Data System (PI‐RADS) before biopsy evaluated utility of combining them in diagnosis cancer (PC). Methods Between November 2021 March 2023, 105 patients admitted to Gunma University Hospital for after undergoing both MRI PHI measurements were enrolled study. We investigated diagnostic impacts [−2]proPSA related indexes on clinically significant PC (csPC) complementary effects PI‐RADS....
Abstract BACKGROUND Estrogen is one of the crucial hormones participating in proliferation and carcinogenesis prostate glands. Genetic polymorphisms estrogen metabolism pathway might be involved risk carcinoma development. The authors evaluated association between genetic estrogen‐related enzymes receptors developing familial carcinoma. METHODS In current study, 101 cases with whose first‐degree relatives had 114 healthy age residence‐matched male controls were enrolled. genotypes receptor...
Broccoli is a Brassica vegetable that believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential enhance properties sprouts. Selenium-enriched sprouts were prepared using sodium selenite solution. Their evaluated in human prostate cancer cell lines and compared with those control sprout extract. superior normal inhibiting proliferation, decreasing prostate-specific antigen secretion, inducing...
Carbon ion Radiotherapy for prostate cancer is widely used, however reports are limited from single institute or short follow up. We performed a prospective observational study (GUNMA0702) to evaluate the feasibility and efficacy of carbon radiotherapy localized locally advanced cancer.Between June 2010 August 2013, 304 patients with were treated, median follow-up duration 60 months. All received 57.6 Gy (RBE) in 16 fractions over 4 weeks. Hormonal therapy was given according risk group....
Interleukin (IL)-15 is a pleiotropic cytokine that important for innate and adaptive immune cell homeostasis. The expression of IL-15 protein controlled by posttranscriptional mechanisms. Here, we constructed human vector consisting the IL-2 signal peptide, mature peptide-coding sequences, an out-of-frame growth hormone gene. Human prostate cancer cells, PC-3, transfected with this highly secretable form gene, successfully secreted abundant bioactive protein. In nude mice, PC-3 cells...
Although the percentage of patients with renal cell carcinoma (RCC) extending into venous systems is unexpectedly high, prognostic impact and independency tumor thrombus-related factors on overall survival (OS) remain controversial. Furthermore, various clinicopathologic including OS may change elapsed years after intervention also follow-up duration participants. The aim study to explore independent universal predictive preoperative intraoperative in RCC using subgroup analysis terms...