A5074581196- Hepatitis C virus research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Diabetes and associated disorders
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Pain Management and Treatment
- Metastasis and carcinoma case studies
- Microbial Metabolites in Food Biotechnology
- Alkaline Phosphatase Research Studies
- Genital Health and Disease
- Polyomavirus and related diseases
- Advanced X-ray and CT Imaging
- Gastric Cancer Management and Outcomes
- Bone health and treatments
- Urological Disorders and Treatments
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Gastrointestinal disorders and treatments
Nuffield Orthopaedic Centre
2019
University of Oxford
2018-2019
Yale University
2017
University of Bari Aldo Moro
2014
Santobono Children's Hospital
1990
Local macrophage clean-up Infection, especially by helminths or bacteria, can cause tissue damage (see the Perspective Bouchery and Harris). Minutti et al. studied mouse models of helminth infection fibrosis. They expressed surfactant protein A (a member complement component C1q family) in lung, which enhanced interleukin-4 (IL-4)-mediated proliferation activation alveolar macrophages. This accelerated clearance reduced lung injury. In peritoneum, boosted for liver repair after bacterial...
Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4+ regulatory (Treg) memory (Tmem) T in mouse skin colon, their respective draining lymph nodes (LNs) spleen. In these tissues, we identified Treg cell subpopulations distinct degrees NLT phenotype. Subpopulation pseudotime ordering gene kinetics were consistent recruitment yet the initial NLT-priming LNs final stages...
Psoriasis is a complex inflammatory skin disease affecting ∼3% of the population worldwide. Although type I interferons (IFN-I) are thought to be involved in its pathogenesis, details this relationship remain elusive. Here we show that murine model imiquimod-driven psoriatic inflammation, Foxp3+ regulatory T cells (T reg cells) control inflammation severity by restraining IFN-I. Depletion induces IFN-I and IFN-stimulated gene expression, leads accumulation CD8+ lesional skin. Mononuclear...