A5112276493- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Urological Disorders and Treatments
- Lung Cancer Research Studies
- Cardiac Ischemia and Reperfusion
- Bacterial Infections and Vaccines
- Cardiac pacing and defibrillation studies
- Epigenetics and DNA Methylation
- Pelvic floor disorders treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Medical Research and Treatments
- Urinary Bladder and Prostate Research
- Liver Disease Diagnosis and Treatment
- Surgical Sutures and Adhesives
- Cardiac electrophysiology and arrhythmias
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Wound Healing and Treatments
- Cancer Mechanisms and Therapy
- Viral Infections and Immunology Research
Hebei Medical University
2025
Second Hospital of Hebei Medical University
2025
Hospital of Hebei Province
2025
Cangzhou Central Hospital
2021
Bristol-Myers Squibb (United States)
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
University Hospitals of Cleveland
2019
China Medical University
2018
First Hospital of China Medical University
2018
University Medical Centre Mannheim
2018
While the discovery of immune checkpoint inhibitors has led to robust, durable responses in a range cancers, many patients do not respond currently available therapeutics. Therefore, an urgent need exists identify alternative mechanisms augment immune-mediated clearance tumors. Hematopoetic progenitor kinase 1 (HPK1) is serine-threonine that acts as negative regulator T-cell receptor (TCR) signaling, dampen response. Herein we describe structure-based isofuranones HPK1. Optimization...
Purpose: To evaluate the efficacy and safety of microwave ablation combined with transcatheter arterial chemoembolization for unresectable large-sized hepotocellular carcinoma.Materials methods: Institutional review board approval informed consent were obtained. Between May 2004 December 2006, 34 consecutive patients large hepatocellular carcinoma (>5 cm) alternately enrolled in one two treatment groups: group 1 (n = 18), which TACE was performed alone, 2 16), percutaneous HCC 2–4 weeks...
Abstract Background Comprehensive documentation on consecutive years of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in children is lacking. This study aims to provide an in‐depth analysis the clinical profiles MERS across different age groups, focusing pathogens and recovery time. Methods In this retrospective study, 43 patients diagnosed were enrolled between December 2017 November 2021. Due manifestations at ages, we categorized them into two groups:...
The present study aimed to assess the diagnostic/prognostic value of various clinical tumor markers, including carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin 19 (CYFRA21-1), α-fetoprotein (AFP), carbohydrate antigen-125 (CA-125), antigen-19.9 (CA-19.9) and ferritin, individually or in combination. electro-chemiluminescence immunization method was performed detect levels seven markers 560 cancer patients 103 healthy subjects for comparison. serum measured were...
Background T lymphoma invasion and metastasis 1 (Tiam1) is a potential modifier of tumor development progression. Our previous study in vitro nude mice suggested promotion role Tiam1 on colorectal cancer (CRC). In the present study, we generated Tiam1/C1199-CopGFP transgenic to investigate tumorigenetic, invasive metastatic alterations colon rectum wild-type under 1,2-dimethylhydrazine (DMH) treatment. Methods Transgenic were produced by method pronuclear microinlectlon. Whole-body...
Patients with early-stage non-small cell lung cancer (NSCLC), even stage IA, are at substantial risk of relapse and death. We explored the distinct features molecular alterations immune-related gene expression in Formalin-fixed paraffin-embedded (FFPE) samples from 25 relapsed patients compared non-relapsed through using whole-exome sequencing an immune oncology panel RNA platform. Results showed that chemokine, cytolytic activity tumour-associated antigen signatures exhibited significantly...
In our current study, porous heparin-polyvinylpyrrolidone/TiO 2 nanocomposite (HpPVP/TiO ) bandage were prepared via the incorporation of TiO into HpPVP hydrogels for biomedical applications such as burn infection. The effect and nanoparticles composition on functional group surface properties as-fabricated bandages characterized by Fourier transform infrared spectroscopy (FTIR) X-ray diffractometry (XRD). presence created internal structure hydrogel that aids in a homogeneous structure,...
The aim of this study was to evaluate the curative effect gamma knife stereotactic body radiotherapy (SBRT) for unresectable massive primary liver cancer. A total 69 patients with (>10 cm) cancer who were treated by SBRT at Department Radiation Oncology 323 Hospital People's Liberation Army (Xi'an, China) between October, 2006 and 2010, analyzed. According Union International Cancer Control TNM staging guidelines, graded as stage T1 (n=8), T2 (n=12), T3 (n=21) T4 (n=28). None had lymph node...
Objective To evaluate the treatment results and psychological changes in female patients with stress urinary incontinence (SUI) before after TVT-O.Methods Fifty-six SUI underwent TVT-O from Nov.2011 to Mar.2012.Preoperative postoperative International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) score,Incontinence Quality of Life (I-QOL) score,one hour urine pad test,Self-rating Anxiety Scale (SAS) score,and Self-rating Depression (SDS) score were recorded analyzed.Results...