Maximiliano Álvarez-Fernández

ORCID: 0000-0002-3831-5046
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About
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Research Areas
  • Oral microbiology and periodontitis research
  • Antimicrobial Resistance in Staphylococcus
  • Infective Endocarditis Diagnosis and Management
  • Bacterial Identification and Susceptibility Testing
  • Streptococcal Infections and Treatments
  • Bacterial biofilms and quorum sensing
  • Bacterial Infections and Vaccines
  • Pneumonia and Respiratory Infections
  • Probiotics and Fermented Foods
  • Otolaryngology and Infectious Diseases
  • Nosocomial Infections in ICU
  • Antibiotic Resistance in Bacteria
  • Antifungal resistance and susceptibility
  • Infectious Diseases and Tuberculosis
  • Plant Pathogens and Fungal Diseases
  • Plant Pathogenic Bacteria Studies
  • Clostridium difficile and Clostridium perfringens research
  • Microbial Metabolism and Applications
  • Reproductive tract infections research
  • Fungal Infections and Studies
  • Salivary Gland Disorders and Functions
  • Cerebrospinal fluid and hydrocephalus
  • Antibiotics Pharmacokinetics and Efficacy
  • Syphilis Diagnosis and Treatment
  • Helicobacter pylori-related gastroenterology studies

University Hospital Complex Of Vigo
2014-2023

Complexo Hospitalario Universitario A Coruña
2013-2022

Galicia Sur Biomedical Foundation
2020-2022

Czech Academy of Sciences, Institute of Microbiology
2022

Universidade de Vigo
2022

Servicio Gallego de Salud
2022

Instituto de Investigación Sanitaria de Santiago
2017-2020

Hospital Xeral Calde
2003-2016

Central University Hospital of Asturias
2015

Universidade de Santiago de Compostela
1999-2007

Objective: To investigate the prevalence, duration and aetiology of bacteraemia following dental extractions, analysing factors affecting its development. Subjects methods: The study group was composed 53 patients undergoing extractions under general anaesthesia. Peripheral venous blood samples were collected at baseline 30 s, 15 min 1 h after extractions. Samples inoculated into BACTEC PLUS aerobic anaerobic culture bottles processed in Bactec 9240. Subculture further identification...

10.1111/j.1601-0825.2006.01247.x article EN Oral Diseases 2007-01-01

Neither breakpoints (BPs) nor epidemiological cutoff values (ECVs) have been established for Candida spp. with anidulafungin, caspofungin, and micafungin when using the Sensititre YeastOne (SYO) broth dilution colorimetric method. In addition, reference caspofungin MICs so far proven to be unreliable. species wild-type (WT) MIC distributions (for microorganisms in a species/drug combination no detectable phenotypic resistance) were 6,007 albicans, 186 C. dubliniensis, 3,188 glabrata complex,...

10.1128/aac.01250-15 article EN Antimicrobial Agents and Chemotherapy 2015-08-18

Objective The current manuscript aims to determine the prevalence, duration and bacterial diversity of bacteraemia following dental extractions using conventional culture-dependent methods 16S rDNA pyrosequencing. Methods study group included 8 patients undergoing under general anaesthesia. Peripheral venous blood samples were collected at baseline, 30 seconds 15 minutes after extractions. Blood analysed for applying microbiological cultures aerobic anaerobic conditions as well...

10.1371/journal.pone.0057782 article EN cc-by PLoS ONE 2013-03-04

To investigate the prevalence, duration and aetiology of bacteraemias following placement implants as well prophylactic efficacy a chlorhexidine digluconate (CHX) mouthrinse.Fifty patients undergoing implant were randomly distributed into two groups:30 with no intervention before surgery. CHX group: 20 who performed 0.2% mouthrinse Blood samples collected at baseline, 30 s after insertion 15 min completion suturing mucoperiosteal flap. Samples processed in Bactec 9240, subculture further...

10.1111/j.1600-0501.2010.01928.x article EN Clinical Oral Implants Research 2010-04-20

Objective. To investigate the prevalence, duration, and etiology of bacteremia following dental extractions performed after a single administration Chlorhexidine mouthwash. Design Setting. A randomized, controlled trial in university hospital. Methods. series 106 patients with mental behavioral disabilities who underwent under general anesthesia were randomly assigned to control group or group. The exclusion criteria applied use antibiotics previous 3 months, oral antiseptics, any type...

10.1086/516663 article EN Infection Control and Hospital Epidemiology 2007-04-19

Background: The prevalence and amounts of periodontal pathogens detected in bacteraemia samples after tooth brushing-induced by means four diagnostic technique, three based on culture one a molecular-based have been compared this study.Material Methods: Blood were collected from thirty-six subjects with different status (17 healthy, 10 gingivitis 9 periodontitis) at baseline 2 minutes brushing.Each sample was analyzed culture-based methods [direct anaerobic culturing (DAC), hemo-culture...

10.4317/medoral.20842 article EN Medicina oral, patología oral y cirugía bucal 2016-01-01

Objectives To investigate the development of post-extraction bacteraemia (PEB) after prophylactic use chlorhexidine (CHX). Patients and Methods A total 201 patients who underwent a tooth extraction were randomly distributed into four groups: 52 received no prophylaxis (CONTROL), 50 did mouthwash with 0.2% CHX before (CHX-MW), 51 subgingival irrigation 1% (CHX-MW/SUB_IR) 48 continuous supragingival (CHX-MW/SUPRA_IR). Peripheral venous blood samples collected at baseline, 30 seconds performing...

10.1371/journal.pone.0124249 article EN cc-by PLoS ONE 2015-05-08

Summary Expert committees on bacterial endocarditis prophylaxis have provided differing opinions whether tracheal intubation is an ‘at‐risk’ manipulation. We studied the incidence of bacteraemia after orotracheal and nasotracheal intubation. The study group comprised 110 patients who underwent surgery under general anaesthesia. Venous blood samples were collected from each patient at baseline 30 s Samples processed with conventional microbiological techniques. Bacteraemia was detected in 13...

10.1111/j.1365-2044.2008.05449.x article EN Anaesthesia 2008-05-09

To evaluate the in vivo antimicrobial activity of chlorhexidine (CHX) saliva 7 h after its application using an epifluorescence microscopy technique.Fifteen volunteers performed a single mouthrinse with sterile water (SM-water) and 0.2% CHX (SM-0.2% CHX). Saliva samples were taken at 30 s 1, 3, 5 each application. The bacterial suspension was mixed SYTO 9/propidium iodide staining observed Olympus BX51 microscope. mean percentage viable bacteria calculated for sample.In comparison baseline...

10.1111/j.1601-0825.2009.01570.x article EN Oral Diseases 2009-04-21

Endoscopes represent the medical devices most commonly linked to health care-associated outbreaks and pseudo-outbreaks. Most of recent pseudo-outbreaks have resulted from contaminated automated endoscope reprocessors (AER) or use damaged malfunctioning bronchoscopes equipment.We investigated a pseudo-outbreak Pseudomonas putida Stenotrophomonas maltophilia recovered bronchial washing (BW) specimens obtained during bronchoscopy in unit.Samples were environmental surfaces endoscopy suite,...

10.1159/000449137 article EN Respiration 2016-01-01

Some evidence-based bundles have tried to standardize the management of Staphylococcus aureus bacteraemia (SAB) improve outcome. The aim our study was analyse additional impact on mortality a structured intervention in patients with SAB.Compliance bundle evaluated an ambispective cohort SAB, which included retrospective [including treated before and after implementation programme (no-BP BP, respectively)] prospective (i-BP), specific for application implemented. Multivariate logistic...

10.1093/jac/dky556 article EN Journal of Antimicrobial Chemotherapy 2019-01-09

Treatment optimization for serious infections, such as Staphylococcus aureus bacteremia (SAB), is a challenge antimicrobial stewardship teams. Currently, SAB guidelines recommend completely intravenous therapy (CIT).The objective of the study was to analyze usefulness and safety oral sequential (OST) in SAB.We conducted retrospective, observational tertiary teaching hospital Spain. The inclusion criteria were complicated non-complicated monomicrobial an adequate duration therapy, with...

10.1016/j.ijid.2020.10.097 article EN cc-by-nc-nd International Journal of Infectious Diseases 2020-11-03

A new α-haemolytic streptococcal strain has been isolated from the dental plaque of a teenager with Down syndrome. Genetic and taxonomic analyses place this Streptococcus within oralis group. It is Gram-stain-positive, non-motile, non-spore-forming spherical alpha-haemolytic coccus arranged in chains, it ferments large number monosaccharides disaccharides, as well polymeric carbohydrates. differs biochemically closely related species due to its production α-galactosidase, β-galactosidase...

10.1099/ijsem.0.004180 article EN INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY 2020-06-15

Systemic dissemination of oral bacteria to distant body sites may be the cause focal infections. The unsuitable use and overexposure antimicrobial therapy in clinical dental practice contribute worldwide problem resistance. aim this study was determine susceptibilities streptococci isolated from bloodstream after extractions against penicillin, ampicillin, amoxicillin, erythromycin, clindamycin, a new fluoroquinolone, moxifloxacin.Eighty-four patients who required were studied. Venous blood...

10.1111/j.1399-302x.2004.00167.x article EN Oral Microbiology and Immunology 2004-08-24

Two genes encoding for aminoglycoside-(3)-N-acctyltransferases (AAC(3)s) of different substrate patterns, present in multiresistance plasmids hospital strains Serratia marcescens and Escherichia coli isolated from urine, have been cloned characterized. The first, aacC1 with AAC(3)I activity, contained a 531 base pair open reading frame which encodes polypeptide 177 aminoacids 19,392 daltons, confirmed by minicell analysis. Its sequence differed previously published work four positions. Three...

10.1093/jac/28.3.333 article EN Journal of Antimicrobial Chemotherapy 1991-01-01

Introduction: Obligate anaerobes are closely involved in the pathogenesis of oral and focal infections. The objective this study was to evaluate susceptibility profiles obligate origin telithromycin (TLM), moxifloxacin (MXF), other antibiotics that commonly used dentistry. Methods: sample comprised 172 isolated from saliva 43 adult volunteers. minimum inhibitory concentrations (MICs) were determined by agar dilution technique Brucella medium supplemented with vitamin K, haemin 5%...

10.1111/j.1399-302x.2007.00359.x article EN Oral Microbiology and Immunology 2007-08-30
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