A5040029719- Sulfur Compounds in Biology
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Obstructive Sleep Apnea Research
- Fibroblast Growth Factor Research
- Neuroscience and Neuropharmacology Research
- Cardiac pacing and defibrillation studies
- Asthma and respiratory diseases
- Ion Transport and Channel Regulation
- Advanced biosensing and bioanalysis techniques
- Air Quality and Health Impacts
- Psoriasis: Treatment and Pathogenesis
- Molecular Sensors and Ion Detection
- Pharmacological Effects and Toxicity Studies
- Cardiac electrophysiology and arrhythmias
- Diet and metabolism studies
- Biosensors and Analytical Detection
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- Drug Transport and Resistance Mechanisms
- Aquaculture disease management and microbiota
- Nitric Oxide and Endothelin Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pharmacological Receptor Mechanisms and Effects
Chinese PLA General Hospital
2024
Renji Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
First Hospital of Shijiazhuang
2016-2023
Xingtai People's Hospital
2023
Second Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Laurentian University
2016-2020
Health Sciences North
2017-2018
Science North
2018
Both estrogen and hydrogen sulfide (H2S) have been shown to inhibit the development of atherosclerosis. We previously reported that cystathionine γ-lyase knockout (CSE-KO) male mice develop atherosclerosis earlier than wild-type (WT) mice. The present study investigated interaction CSE/H2S pathway on in female Plasma levels were significantly lower CSE-KO WT NaHS treatment had no effect plasma both After fed with atherogenic diet for 12 wk, lipid increased triglyceride decreased compared...
Lamotrigine (LTG) is a broad-spectrum antiepileptic drug that widely used in clinic. However, the effect of LTG on cognition and neurodegeneration during epilepsy treatment remains controversial. In this study, we compared cognitive effects sodium valproate pentylenetetrazole (PTZ)-kindled animal model, dose dependency was tested for LTG.PTZ-kindled animals were divided into following groups: control group, treated with 3.5 mL/kg 0.9% chloride; low-dose 12.5 mg/kg LTG; middle-dose 25...
The ketogenic diet (KD) is a proven therapy for refractory epilepsy. Although the anti-seizure properties of this are understood to certain extent, exploration its neuroprotective effects and underlying mechanisms still in infancy. Tissue acidosis common feature epileptogenic foci. Interestingly, activation acid-sensing ion channel 1a (ASIC1a), which mediates Ca2+-dependent neuronal injury during acidosis, has been found be inhibited by ketone bodies vitro. This prompted us investigate...
The pathogenic mechanisms for the higher prevalence of allergic asthma in children than adults have not been settled. aim present study is to examine whether age-dependent development caused by expression cystathionine gamma-lyase (CSE), a key enzyme that catalyzes production hydrogen sulfide (H2S).Allergic was induced with ovalbumin wild-type (WT) and CSE knock-out (KO) mice at young old ages. H2S were lower immune cells WT those mice. Coincidentally, more severe asthmatic symptoms greater...
The production of H 2 S and its effect on bioenergetics in mammalian cells may be evolutionarily preserved. Erythrocytes birds, but not those mammals, have a nucleus mitochondria. In the present study, we report endogenous chicken erythrocytes, which was mainly catalyzed by 3-mercaptopyruvate sulfur transferase (MST). ATP content erythrocytes increased MST-generated under normoxic, hypoxic, conditions. NaHS, salt, contents absence or presence NaHS were eliminated different inhibitors for...
Both estrogen and hydrogen sulfide (H 2 S) inhibit the proliferation of vascular smooth muscle cells (SMCs) development atherosclerosis. In absence endogenous H S as occurred in CSE-knockout (KO) mouse, however, stimulates SMCs. The underlying mechanisms for this seemingly controversial effect are unclear. present study, we demonstrated that stimulatory on CSE-KO SMCs was suppressed by inhibitor insulin-like growth factor-1 receptor (IGF-1R) or knockdown IGF-1R protein expression. Estrogen...
Cervical cancer is among the most common malignant tumors in women. The development of rapid screening techniques plays an important role early for treatment. We have developed HPV method, which effectively combines high-efficiency nucleic acid enrichment chitosan-modified filter paper and visual detectability colorimetric LAMP, along with enhancement tolerance ability pH-sensitive LAMP reagent to acidic original samples, making detection 16/18 easy carry out reliable, helpful...
Despite the good cooling effect of contact-force porous catheter, risk steam pops (SP) remains one major concerns in high-power circumferential pulmonary vein isolation (CPVI). This study aimed to investigate prevalence, predictors and possible mechanisms SPs CPVI. Patients experiencing de novo CPVI were 1:3 matched by non-SP patients with gender, age (±5 years) left atrial diameter (LAD) mm) compare ablation parameters SP lesions. Catheter tip displacement (Tipdisp) was compared between...
Ethanol infusion into the VOM (EIVOM) adjunctive to radiofrequency catheter ablation (RFCA) was a novel approach facilitating mitral isthmus (MIth) block for persistent atrial fibrillation (PeAF); However, there were remarkable disparities in its technical aspects. This study aimed evaluate impact of EIVOM aspects on acute MIth block.Eighty consecutive patients (63 males, average age 66.4 ± 8.6 years) undergoing de novo PeAF assigned different groups. The procedural parameters "EIVOM first"...
Abstract Background The association between psoriasis (PSO) and depression has recently gained significant attention among researchers. However, the precise nature of relationship these two conditions remains to be determined. objective this study is investigate a causality PSO using two-sample mendelian randomization (MR) approach. Methods Summary statistics for were derived from multiple comprehensive genome-wide studies. A MR design was employed examine causal depression. primary analyses...