A5083643122- Eating Disorders and Behaviors
- HIV Research and Treatment
- Planetary Science and Exploration
- Obesity, Physical Activity, Diet
- Cardiac electrophysiology and arrhythmias
- Particle Accelerators and Free-Electron Lasers
- Obsessive-Compulsive Spectrum Disorders
- Obesity and Health Practices
- Impact of Technology on Adolescents
- Particle accelerators and beam dynamics
- Ion channel regulation and function
- Personality Disorders and Psychopathology
- HIV/AIDS Research and Interventions
- Eosinophilic Esophagitis
- Gyrotron and Vacuum Electronics Research
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced X-ray Imaging Techniques
- COVID-19 and Mental Health
- Nuclear Physics and Applications
- Eosinophilic Disorders and Syndromes
- Neuroinflammation and Neurodegeneration Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Space Exploration and Technology
- HIV/AIDS drug development and treatment
- Cancer Treatment and Pharmacology
United States University
2025
Uniformed Services University of the Health Sciences
2023-2024
University of North Carolina at Chapel Hill
2018-2023
University of North Carolina Health Care
2023
National Institutes of Health
1992-2019
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2015-2019
Search for Extraterrestrial Intelligence
2017-2019
Mayo Clinic in Arizona
2013-2017
Michigan State University
2017
United States Department of Health and Human Services
2016
The relationship between debrisoquine metabolic phenotype and the pharmacokinetics pharmacodynamics of propafenone was studied in 28 patients with chronic ventricular arrhythmias (22 extensive metabolizers [EMs] six poor [PMs] debrisoquine). EMs were characterized by a shorter elimination half-life (5.5 +/- 2.1 vs 17.2 8.0, p less than .001), lower average plasma concentration (Cp) (1.1 0.6 2.5 0.5 ng/ml/mg daily dosage, higher oral clearance (1115 1238 264 48 ml/min, .001). active...
A retrospective analysis of 260 completed intrauterine insemination (IUI) cycles was used in an attempt to identify significant variables predictive treatment success. Couples received a maximum three IUI for the anovulation, cervical factors or unexplained infertility. Male factor problems were largely excluded by pretreatment screening. The overall pregnancy rate 19.6% per cycle, miscarriage 15.6%, multiple 23.5% and cancellation 19%. Logistic regression identified four [follicle number (P...
Objective: To determine if stavudine (α4T)-associated mitochondrial toxicity could be reversed by substitution with another nucleoside reverse transcriptase inhibitor. As apoptosis and dysfunction of electron transport chain (ETC) activities may underlie toxicity, these parameters were also evaluated. Design: The 16 participants (on d4T for >3 years; lipoatrophy and/or hyperlactatemia) substituted abacavir or zidovudine in their antiretroviral regimen. Key including dual-energy X-ray...
Patients with Alzheimer's disease (AD) show varying degrees of awareness their deficits. To examine the impact this phenomenon upon distress experienced by family caregivers AD patients, we analyzed caregiver burden in relation to patient deficit three different functional domains. The relationship selected sociodemographic variables was also explored. Results multiple regression analyses suggested that associated impaired memory independent stage and dementia severity. findings suggest may...
The pathogenesis of HIV-associated dementia (HIVD) has been postulated to be due the indirect effects HIV infection, including aberrant central nervous system production cytokines and other neurotoxins. A correlation between severity neurotoxins in HIVD demonstrated. We have previously identified nonproductive infection astrocytes. Because astrocytes participate inactivation neurotoxins, we hypothesize that may lead an environment which there is a significant level astrocyte apoptosis...
ABSTRACT Objective Adolescent emotional‐eating, referring to eating in response negative affective states, is frequently reported by those with loss of control (LOC) eating. Although LOC has been shown predict exacerbated disordered and excess weight/adiposity gain, the extent which either alone or combination LOC, predicts adverse outcomes not determined. Thus, we examined associations baseline emotional‐eating changes eating, BMI, adiposity over 1‐year, what degree presence absence...
Abstract Objective Eating disorder recovery research has emphasized the absence of symptoms over presence adaptive aspects like positive body image and healthy eating attitudes. The current study examined how appreciation intuitive related to using a comprehensive definition (physical, behavioral, cognitive recovery). Method Data were collected from 66 women with an history 31 controls no pathology. Participants completed online survey followed by phone interview. Results fully recovered...
This study examined demographic and military factors related to probability of hospitalization among military-affiliated adolescents young adults (AYA) with an eating disorder (ED) diagnosis. Participants were AYA (spouses not included), ages 10-26 years. De-identified data extracted from the Military Health System Data Repository 2016-2021. Kaplan-Meier risk estimates determined proportion participants a following their initial ED diagnosis across time. Cox proportional hazard models...
Abstract We molecularly characterized human immunodeficiency virus type 1 (HIV‐1) present in pure populations of astrocytes, macrophages, and multinucleated giant cells isolated using laser capture microdissection from brain tissue two patients who died with HIV‐associated dementia. The V3 region the HIV‐1 envelope ( env ) gene was amplified pure‐cell populations, multiple clones were sequenced. In both patients, sequences distinct astrocytes compared neighboring macrophages or...
We have identified high and low affinity insulin-like growth factor I (IGF I)-binding sites with mean dissociation constants of 0.37 6.25 nM, respectively, in solubilized placental membranes. separated these purified the IGF receptor 1,300-fold, an overall yield 9.9%, using wheat germ agglutinin-Sepharose chromatography, insulin chromatography. The Scatchard plot binding to is linear, suggesting purification a single homogeneous class sites. Insulin two orders magnitude less effective than...
Recently, a new model of the urinary concentrating process has been proposed that takes into account three-dimensional architecture renal medulla. Under assumptions model, computer simulations predicted significant axial osmolality gradients in inner medulla without active transport by medullary loop Henle. Two (which constitute hypotheses for this study) were: (1) osmotic water permeability initial part collecting duct (initial IMCD) is very low even presence vasopressin; and (2) there...