A5019659335- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Aortic aneurysm repair treatments
- Cardiac Imaging and Diagnostics
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Coronary Artery Anomalies
- COVID-19 and healthcare impacts
- Heart Failure Treatment and Management
- Radiation Dose and Imaging
- Acute Kidney Injury Research
- Cardiac Arrest and Resuscitation
- Radiation Effects and Dosimetry
- Artificial Intelligence in Healthcare and Education
- Diversity and Career in Medicine
Narayana Health
2021-2025
NIHR Bristol Cardiovascular Biomedical Research Unit
2002-2025
Rabindranath Tagore International Institute of Cardiac Sciences
2015-2024
University of Bristol
2002-2023
University of Leicester
2021
San Diego Cardiac Center
2020
Bristol Royal Infirmary
2002-2018
University Hospitals Bristol NHS Foundation Trust
2018
Papworth Hospital NHS Foundation Trust
2017
Defence Laboratory Jodhpur
2007-2010
Introduction Anemia, a frequently encountered issue among cancer patients undergoing chemotherapy, is regrettably underappreciated despite its prevalence and profound impact on their well-being. Chemotherapy-induced anemia (CIA) diminishes the quality of life, causing fatigue, breathlessness, decline in performance status. However, correcting can lead to notable improvements these parameters. Notably, darbepoetin alpha (DA) has shown efficacy addressing this context. This real-world study...
Abstract Background The Society of Thoracic Surgeons and European System for Cardiac Operative Risk Evaluation (EuroSCORE) II risk scores are the most commonly used prediction models in-hospital mortality after adult cardiac surgery. However, they prone to miscalibration over time poor generalization across data sets; thus, their use remains controversial. Despite increased interest, a gap in understanding effect set drift on performance machine learning (ML) barrier its wider clinical...
Heart failure (HF) is a complex syndrome. Despite availability of multiple treatment options, the mortality remains high and quality life poor. Better understanding underlying pathophysiological processes can lead to development novel therapies. Multiple comparative transcriptomics studies, which revealed gene level changes in key pathways failing hearts, point towards heterogeneity from interplay disease stage, etiologies ethnicity. Transcriptomic characterization HF patients different...
The capability to accurately predict the ejection fraction (EF) from an electrocardiogram (ECG) holds significant and valuable clinical implications. Various algorithms based on ECG images are currently being evaluated, with most methods requiring raw signal data devices. In this study, our objective was train validate a neural network readily available trace image graph determine presence or absence of left ventricular dysfunction (LVD). 12-lead paired their echocardiogram reports performed...
Surgical aortic valve replacement (SAVR) is traditionally the gold-standard treatment in patients with disease. The advancement of transcatheter (TAVR) provides an alternative to high surgical risks and those who had previous cardiac surgery. We aim evaluate trend, early clinical outcomes, choice prosthesis use isolated SAVR United Kingdom.All (n = 79,173) underwent elective or urgent from 1996 2018 were extracted National Adult Cardiac Surgery Audit database. Patients additional procedures...
Objective The introduction of new clinical risk scores (e.g. European System for Cardiac Operative Risk Evaluation (EuroSCORE) II) superseding original EuroSCORE I) with different variable sets typically result in disparate datasets due to high levels missingness score variables prior time adoption. Little is known about the use ensemble learning incorporate data from legacy scores. We tested hypothesised that Homogenenous and Heterogeneous Machine Learning (ML) ensembles will have better...
Objective: Endovascular treatment is increasingly used to treat complicated aortic pathology. The aim of the study was assess if compared with operative repair, thoracic endovascular repair aorta (TEVAR) associated a cost benefit in management diseases affecting descending aorta. We also early and mid-term outcomes between two groups. Methods: Clinical characteristics, hospitalisation costs 84 consecutive patients undergoing intervention for conditions were reviewed retrospectively....
Thoracic organ transplantation is an effective form of treatment for end-stage heart and lung disease. Despite major advances in the field, transplant patients remain at risk acute allograft dysfunction, a cause early late mortality. The most common causes failure include primary graft secondary to inadequate preservation during cold storage, cellular rejection, various donor-recipient-related factors. During storage reperfusion, allografts are vulnerable intracellular calcium overload,...
To assess the safety and efficacy of on-pump beating heart coronary surgery on organ function, early late health outcome as compared with conventional technique.A total 81 patients were randomised to (1) cardiopulmonary bypass (CPB) cardioplegic arrest (CA) (on-pump CA, n=41) or (2) CPB without CA n=40). Primary outcomes included serial measurement interleukins (IL-6, IL-8 IL-10) for inflammation, troponin I myocardial injury, protein S100 cerebral injury creatinine clearance (CrCl) urinary...