A5013665481- SARS-CoV-2 and COVID-19 Research
- Child Development and Digital Technology
- COVID-19 Clinical Research Studies
- Impact of Technology on Adolescents
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Genomics and Phylogenetic Studies
- Viral Infections and Immunology Research
- Social Media and Politics
- RNA and protein synthesis mechanisms
- Privacy, Security, and Data Protection
- Cardiac Valve Diseases and Treatments
- Immune Cell Function and Interaction
- Gene expression and cancer classification
- Formal Methods in Verification
- CRISPR and Genetic Engineering
- Tuberculosis Research and Epidemiology
- Gene Regulatory Network Analysis
- Mechanical Circulatory Support Devices
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
Institute of Life Sciences
2017-2025
Indian Institute of Technology Bhubaneswar
2018-2025
Jacksonville State University
2020-2025
KIIT University
2018-2025
National Institute for Research in Tribal Health
2024-2025
Burdwan Medical College & Hospital
2024
University of Calcutta
2024
Indian Council of Medical Research
2023
Rabindranath Tagore International Institute of Cardiac Sciences
2021-2022
Government of India
2021-2022
We conducted a structured, qualitative feature analysis of 75 Android mobile apps designed for the purpose promoting adolescent online safety. Through this we identified 42 unique features that mapped to theoretically derived conceptual framework teen safety strategies balanced between parental control (through monitoring, restriction, and active mediation) self-regulation self-monitoring, impulse control, risk-coping). found strongly favored promote through monitoring restricting teens'...
Mobile applications ("apps") developed to promote online safety for children are underutilized and rely heavily on parental control features that monitor restrict their child's mobile activities. This asymmetry in surveillance initiates an interesting research question -- how do themselves feel about such apps? We conducted a qualitative analysis of 736 reviews 37 apps from Google Play were publicly posted written by (ages 8-19). Our results indicate child ratings significantly lower than...
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has emerged as a global pandemic worldwide. In this study, we used ARTIC primers–based amplicon sequencing to profile 225 SARS-CoV-2 genomes from India. Phylogenetic analysis of 202 high-quality assemblies identified presence all five reported clades 19A, 19B, 20A, 20B, and 20C in population. The analyses revealed Europe Southeast Asia two major routes for introduction India...
Rewiring tumor cells to undergo drug-induced apoptosis is a promising way overcome chemoresistance. Therefore, identifying causative factors for chemoresistance of high importance. Unbiased global proteome profiling sensitive, early, and late cisplatin-resistant oral squamous cell carcinoma (OSCC) lines identified CMTM6 as top-ranked upregulated protein. Analyses OSCC patient samples demonstrated significantly higher expression in chemotherapy (CT) nonresponders compared with CT responders....
Adoption rates of parental control applications ("apps") for teens' mobile devices are low, but little is known about the characteristics parents (or teens) who use these apps. We conducted a web-based survey 215 and their teens (ages 13-17) using two separate logistic regression models (parent teen) to examine factors that predicted technical monitoring apps on devices. Both parent teen confirmed low autonomy granting (e.g., authoritarian) were most likely The model revealed additional...
Traditional parental control applications designed to protect children and teens from online risks do so through restrictions privacy-invasive monitoring. We propose a new approach adolescent safety that aims strike balance between teen's privacy their active communication fostering trust parents children. developed an Android "app" called Circle of Trust conducted mixed methods user study 17 parent-child pairs understand perceptions about the app. Using within-subjects experimental design,...
Abstract During the course of COVID-19 pandemic, large-scale genome sequencing SARS-CoV-2 has been useful in tracking its spread and identifying variants concern (VOC). Viral host factors could contribute to variability within a that can be captured next-generation reads as intra-host single nucleotide variations (iSNVs). Analysing 1347 samples collected till June 2020, we recorded 16 410 iSNV sites throughout genome. We found ∼42% reported SNVs by 30 September 2020 consensus sequences...
Whole genome sequencing has been used to investigate the genomic diversity of M. tuberculosis in northern and southern states India, but information about eastern part country is still limited. Through a sequencing-based strategy, this study seeks comprehend drug resistance pattern region. A total 102 isolates from North East (n = 54), Odisha 48) were sequenced along with 7 follow up Sikkim. The pre-XDR XDR diagnosed as per NTEP diagnostic algorithm subjected for phenotypic second-line...
The probability of exposure to radioactive substances like uranium has increased considerably with the significant growth in use nuclear power various sectors, which endangers environment and...
Abstract Leprosy, caused by Mycobacterium leprae and lepromatosis, remains a significant global health issue despite tremendous decline in its worldwide prevalence the last four decades. strains possess very limited genetic variability, making it difficult to distinguish them using traditional genotyping tools. Successful genome sequencing of considerable number M. recent past has allowed development improved tools for molecular epidemiology leprosy. Comparative genomics identified distinct...
Background— We sought to compare the effects on ophthalmic function of coronary artery bypass grafting (CABG) with cardiopulmonary (CPB) and off-pump (OPCAB) investigate whether retinal microvascular damage is associated markers cerebral injury. Methods Results— Retinal was assessed by fluorescein angiography color fundus photography. Ophthalmic tested logarithm minimum angle resolution visual acuity (VA), injury, transcranial Doppler ultrasound–detected emboli S100 protein values. Twenty...
Syrian golden hamsters (Mesocricetus auratus) infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manifests lung pathology. In this study, efforts were made to check the infectivity of a local SARS-CoV-2 isolate in self-limiting and non-lethal hamster model evaluate differential expression proteins during infection convalescence. The findings study confirm vivo. Analysis clinical parameters tissue samples show pathophysiological manifestation similar that reported...
The role of Epithelial to Mesenchymal Transition (EMT) factor Zeb1 is well defined in metastasis and cancer progression but it's importance dendritic cells (DCs) unexplored until now. For the first time we report here that controls immunogenic responses CD8α+ conventional Type-I (cDC1) DCs. We found ZEB1 expression increases significantly after TLR9 stimulation its depletion impair activation, co-stimulation secretion important cytokines like IL-6, IL-10 IL-12 cDC1 MutuDC line. further...
The peptidoglycan (PG) layer, a crucial component of the tripartite E.coli envelope, is required to maintain cellular integrity, protecting cells from mechanical stress resulting intracellular turgor pressure. Thus, coordinating synthesis and hydrolysis PG during cell division (septal PG) for bacteria. FtsEX complex directs septal through activation amidases; however, mechanism regulation are unclear. In addition, how coordinated has remained Here, we have shown that overexpression FtsE...
Mycobacterium tuberculosis ( Mtb ) defends host-mediated killing by repressing the autophagolysosome machinery. For first time, we report NCoR1 co-repressor as a crucial host factor, controlling growth in myeloid cells regulating both autophagosome maturation and lysosome biogenesis. We found that dynamic expression of is compromised human peripheral blood mononuclear (PBMCs) during active infection, which rescued upon prolonged anti-mycobacterial therapy. In addition, loss function...
A large number of genomic regions, such as transcription factor binding sites (TFBSs) captured from next generation sequencing (NGS) data analyses or those available the public resource database ENCODE, are generally overlapped to answer a variety biological questions. Though several command-line tools perform an analysis, there is notable lack integrated webserver application with which identify region intersections, generate publication-ready plots depicting subsets and functional...
While there has been much research studying technology in family contexts, little to no explored the challenges and risks faced online by teens their parents foster care situations. To address this gap, we have begun conduct in-depth, semi-structured interviews with of teens. Our preliminary findings suggest that situations face unique offline (e.g., victims sex trafficking or rape) make them more vulnerable risks. In addition, struggle managing high-risk behavior The purpose paper is...
Dendritic cell (DC) activation and cytokine production is tightly regulated. In this study, we found that Zbtb10 expression dependent it essential for the immunogenic function of cDC1. knockdown (KD) significantly reduced co-stimulatory genes CD80 CD86 along with cytokines including IL-12, IL-6, IL-10, in activated cDC1 Mutu-DC line. Consequently, clonal expansion CD44+ effector T cells co-cultured CD4+ was drastically owing to IL-2. At same time, these were unable differentiate toward Tbet+...