A5032222246- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Head and Neck Surgical Oncology
- Systemic Lupus Erythematosus Research
- Health Systems, Economic Evaluations, Quality of Life
- Cerebrospinal fluid and hydrocephalus
- Multiple Myeloma Research and Treatments
- Bone and Joint Diseases
- Hematological disorders and diagnostics
- Quinazolinone synthesis and applications
- Renal cell carcinoma treatment
- Cancer and Skin Lesions
- Renal and related cancers
- Parasitic Diseases Research and Treatment
- HER2/EGFR in Cancer Research
- Teratomas and Epidermoid Cysts
- Inflammatory Biomarkers in Disease Prognosis
Bansal Institute Of Research Technology & Science
2025
Taunton & Somerset NHS Foundation Trust
2025
All India Institute of Medical Sciences Rishikesh
2020-2024
All India Institute of Medical Sciences Raipur
2020-2023
Bristol-Myers Squibb (United States)
2009-2023
King Edward Memorial Hospital and Seth G.S. Medical College
2021-2023
Hindu College of Pharmacy
2022
Gandhi Medical College & Hospital
2022
Mahatma Gandhi Medical College and Research Institute
2022
All India Institute of Medical Sciences Jodhpur
2022
Programmed death 1 (PD-1) protein, a T-cell coinhibitory receptor, and one of its ligands, PD-L1, play pivotal role in the ability tumor cells to evade host's immune system. Blockade interactions between PD-1 PD-L1 enhances function vitro mediates antitumor activity preclinical models.
Abstract Purpose: To determine the maximum tolerated dose, dose-limiting toxicity (DLT), and recommended phase II dose of dasatinib in metastatic solid tumors refractory to standard therapies or for which no effective therapy exists. Experimental Design: In this I, open-label, dose-escalation study, patients received 35 160 mg twice daily 28-day cycles either every 12 hours 5 consecutive days followed by 2 nontreatment week (5D2) as continuous, twice-daily (CDD) dosing. Results: Sixty-seven...
Purpose: Nivolumab is a fully human IgG4 monoclonal antiprogrammed death-1 antibody with demonstrated efficacy, including durable responses and prolonged survival, in patients previously treated, advanced non-small cell lung cancer (NSCLC). Exposure-response (E-R) analyses for efficacy safety were conducted to inform the benefit-risk assessment of nivolumab this patient population.Experimental Design: The used clinical trial data from squamous (n = 293) or nonsquamous 354) NSCLC four trials...
3001 Background: Nivo + ipi is approved in adv melanoma and has demonstrated clinical activity manageable safety various solid tumors. CheckMate 012 a phase I study of nivo monotherapy or combined with other therapies 1L NSCLC; we report updated results, including tumor growth dynamic (TGD) modeling, from N+I dosing schedules explored to optimize permit synergistic activity. Methods: Patients ([pts] N=148, any NSCLC histology) received (mg/kg) across 4 dose cohorts (Table). Primary objective...
Summary We report a case of small cell carcinoma the ovary, hypercalcaemic type, rare and aggressive form ovarian cancer, causing an acute kidney injury. A woman in her mid-30s presented with large pelvic mass abdominal distention, this was associated rapidly deteriorating renal function, which did not improve standardised injury treatment. There high suspicion cancer. She deteriorated underwent emergency cytoreductive surgery, followed by systemic chemotherapy. Her presentation, electrolyte...
Abstract Activating transcription factors (ATFs), members of the adaptive-response gene family, participate in cellular processes to aid adaptations response extra and/or intracellular changes. In this study, we observed that one ATFs, factor 3 (ATF3), is upregulated under hypoxia via alterations epigenetic landscape its promoter, followed by transcriptional upregulation. Under hypoxic conditions, Hypoxia-inducible 1-alpha (HIF1ɑ) alleviates methylation at ATF3 promoter recruiting TET1 and...
Quantitative pharmacology (QP) applications in translational medicine, drug-development, and therapeutic use were crowd-sourced by the ASCPT Impact Influence initiative. Highlighted QP case studies demonstrated faster access to innovative therapies for patients through 1) rational dose selection pivotal trials; 2) reduced trial-burden vulnerable populations; or 3) simplified posology. Critical success factors proactive stakeholder engagement, alignment on value of model-informed approaches,...
2510 Background: Blocking the interaction between programmed death-1 (PD-1), a co-inhibitory receptor expressed by activated T cells, and its ligand PD-L1 may enhance T-cell function. Here we describe safety activity from first clinical study of BMS-936559 in patients (pts) with advanced solid tumors, further validating importance PD-1/PD-L1 pathway as target for cancer therapy. Methods: was given Q2 wk IV 6-wk cycle at doses 0.3−10.0 mg/kg during dose escalation and/or cohort expansion; pts...
Abstract Introduction: The anti-PD-1 checkpoint inhibitor NIVO provides favorable safety and efficacy when administered at 3 mg/kg Q2W across multiple tumor types. Alternative dosing schedules would provide flexibility offer benefits to patients prescribers. A well-established understanding of clinical pharmacology, robust data types well characterized, relatively flat E-R relationships for support the use model-based approaches qualify other potential doses schedules. Methods: feasibility...
Classification of breast lesions into different cytological groups can accurately be done using the International Academy Cytology (IAC) Yokohama System for reporting cytopathology. Fine needle aspiration biopsy (FNAB) has been considered to primary investigation in detecting cancers, especially low-cost settings. The main objective this study was prospectively re-confirm diagnostic accuracy FNAB IAC system. Additionally, separate secondary subgroup analysis confirm excluding lymph-node...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Piperlongumine (PL) has been claimed to have cytotoxic and HCC inhibitory effects in various cancer cell lines xenograft models, but chemopreventive potential PL not studied experimentally induced yet.Twenty-four Wistar male rats were divided into four groups six each, Group A: untreated control; B: Diethylnitrosamine (DEN) control (200 mg/kg), C: DEN + 10 mg/kg; D: 20 mg/kg. Rats from all assessed...
Plasma cell dyscrasias are a heterogeneous group of disorders characterised by the expansion single clone immunoglobulin secreting, terminally differentiated, end-stage B cells.1 Many their clinical and morphological features result production accumulation excessive amounts monoclonal immunoglobulin. Intracellular inclusions, both intracytoplasmic (Russell bodies) intranuclear (Dutcher occasionally seen in bone marrow biopsy specimens from patients with plasma neoplasms, less frequently...
Invasive isolated renal aspergilloma in an immunocompetent host is rare, and few cases have been reported the literature. It a unique entity encountered by urologist that can lead to catastrophic complications like end-stage disease. Infective pathology may closely resemble mass, timely, appropriate investigations are obligatory for early intervention. This case report highlights importance of strong consideration fungal infections differential diagnosis mass with atypical radiological...
Introduction Thyroid eye disease is a multifactorial disorder affecting the tear film and ocular surface, which leads to dry eye. The aim of study evaluate function test surface changes clinically correlate pathologically using impression cytology in recently diagnosed cases thyroid dysfunction, including both hyperthyroid hypothyroid patients, compare results with healthy subjects. Methods This was cross-sectional analytical study. Thirty patients hyperthyroidism hypothyroidism, each within...
The authors have elaborated the cytological features of Warthin-like variant papillary thyroid carcinoma (WLPTC) presenting unusually with nodal metastasis in a 43-year-old lady, and which was reported on cytology as (PTC) lymphocytic thyroiditis.
To report a rare case of bilateral Purtscher-like retinopathy (PLR) in young adult diagnosed with dermatomyositis.
ABSTRACT Low-grade fibromyxoid sarcoma (LGFMS) is a rare malignant spindle cell neoplasm that characteristically involves the trunk and extremities. The bland morphological appearance of tumor makes it notoriously difficult for pathologist to identify in routine microscopic sections especially when located at unconventional sites. This ensues significant therapeutic implications as known long-standing distant metastasis. case 48-year-old lady who was diagnosed with this an extremely uncommon...