A5077803646- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Bat Biology and Ecology Studies
- Animal Virus Infections Studies
- Economic and Technological Developments in Russia
- Economic Sanctions and International Relations
- Hippo pathway signaling and YAP/TAZ
- Mosquito-borne diseases and control
- BRCA gene mutations in cancer
- vaccines and immunoinformatics approaches
- Genetic diversity and population structure
- Ubiquitin and proteasome pathways
- Bacterial Infections and Vaccines
- interferon and immune responses
- Economic, Social, and Public Health Issues in Russia and Globally
- Vector-borne infectious diseases
- Diverse Education Studies and Reforms
- Agriculture and Biological Studies
- Influenza Virus Research Studies
- Neonatal Health and Biochemistry
- Yersinia bacterium, plague, ectoparasites research
- Plant Disease Resistance and Genetics
University of Toronto
2022-2025
Moscow City University
2018
Roswell Park Comprehensive Cancer Center
2014
Tokyo Institute of Technology
2007-2008
Severtsov Institute of Ecology and Evolution
2008
Nofer Institute of Occupational Medicine
2008
Masaryk Memorial Cancer Institute
2008
Lomonosov Moscow State University
2002-2005
Engelhardt Institute of Molecular Biology
2005
Siberian Branch of the Russian Academy of Sciences
2000
Our findings highlight the relative importance of SARS-CoV-2-specific GzmB-producing T cell responses in SARS-CoV-2 control and shared CD4 CD8 immunodominant epitopes seasonal coronaviruses or SARS-CoV-1, they indicate robust persistence memory at least 1 year after infection. should inform future strategies to induce vaccines against other coronaviruses.
Older individuals and people with HIV (PWH) were prioritized for COVID-19 vaccination, yet comprehensive studies of the immunogenicity these vaccines their effects on reservoirs are not available. Our study 68 PWH 23 HIV-negative participants aged 55 older post-three vaccine doses showed equally strong anti-spike IgG responses in serum saliva through week 48 from baseline, while salivary IgA low. had diminished live-virus neutralization after two doses, which 'rescued' post-booster....
The contributions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells to vaccine efficacy and durability are unclear. We investigated relationships between mRNA vaccine-induced spike-specific interferon- gamma (IFN-γ) interleukin-2 (IL-2) T-cell responses neutralizing antibody development in long-term care home staff doubly vaccinated with BNT162b2 or mRNA-1273. impacts pre-existing cross-reactive immunity on cellular humoral vaccination were additionally...
The human immune system is intrinsically variable and remarkably diverse across a population. response to antigens driven by complex interplay of time-dependent interdependencies components the system. After repeated vaccination, humoral cellular arms display highly heterogeneous dynamics, further complicating attribution phenotypic outcome specific components. We employ random forest (RF) approach classify informative differences in immunogenicity between older people living with HIV (PLWH)...
A combined approach based on the complex use of molecular, morphological and ecological data has shown that 'eastern' group forms transpalearctic Daubenton's bat, Myotis daubentonii (Kuhl, 1817), deserves a status distinct species, conforms to M. petax, described by Hollister in 1912 from Republic Altai south Western Siberia. In our genetic analysis we used SINEs (short interspersed elements) nuclear DNA as markers, means Inter-SINE-PCR, have clearly demonstrated species distinctiveness...
Short interspersed elements (SINEs) constitute a group of retroposons propagating in the genome via mechanism reverse transcription, which they depend on enzymatic machinery long (LINEs). Over 70 SINE families have been described to date from genomes various eukaryotes. Here, we characterize two novel SINEs salmons (Actinopterygii: Salmonoidei). The first family, termed SlmI, was shown be widespread among all genera suborder. These tRNALeu-related promoter region at their 5′-end, unique...
In the last decade taxane-based therapy has emerged as a standard of care for hormone-refractory prostate cancer. Nevertheless, significant fraction tumors show no appreciable response to treatment, while others develop resistance and recur. Despite years intense research, mechanisms taxane in cancer other malignancies are poorly understood remain topic investigation. We have used improved mutagenesis via random insertion strong promoter search events, which enable survival cells after Taxol...
Thirty-one bat species have been registered in the course of two expeditions to Cambodia JanuaryFebruary 2000 and JulySeptember 2002.Eight them, namely Macroglossus sobrinus, Taphozous theobaldi, Hipposideros cineraceus, H. galeritus, Rhinolophus pusillus, Miniopterus schreibersii, sp., Harpiocephalus harpia are reported from for first time.Occurrence Rousettus leschenaulti Pteropus hypomelanus is confirmed, while that Saccolaimus saccolaimus, on contrary, rejected.Specific distinctiveness...
Older individuals and people with HIV (PWH) were prioritized for COVID-19 vaccination, yet comprehensive studies of the immunogenicity these vaccines their effects on reservoirs are not available. We followed 68 PWH aged 55 older 23 age-matched HIV-negative 48 weeks from first vaccine dose, after total three doses. All antiretroviral therapy (cART) had different immune status, including responders (IR), non-responders (INR), low-level viremia (LLV). measured neutralizing Ab responses to...
Трудовое право и социального обеспечения 97 Правовое регулирование семейного образования на региональном муниципальном уровнях МАТВЕЕВ Виталий Юрьевич, заведующий лабораторией образовательного права Юридического института Московского городского педагогического университета,
Older individuals and people with HIV (PWH) were prioritized for COVID-19 vaccination, yet comprehensive studies of the immunogenicity these vaccines their effects on reservoirs are not available. Our study 68 PWH 23 HIV-negative participants aged 55 older post-three vaccine doses showed equally strong anti-spike IgG responses in serum saliva through week 48 from baseline, while salivary IgA low. had diminished live-virus neutralization after two doses, which ‘rescued’ post-booster....
Abstract PR-6 The conversion of vitamin D to its main biologically active form, 1,25-dihydroxy D, occurs in the kidney. Since most form exerts activity through binding intracellular receptor (VDR), studies genetic susceptibility have primarily focused on variation within VDR gene. But, concert genes that interact with are vast; therefore, an analysis and other pathway may provide insight into role renal cell carcinoma (RCC) etiology. In this case-control study, we investigated relationship...