A5047359880- Lipid metabolism and biosynthesis
- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Photosynthetic Processes and Mechanisms
- Analytical Chemistry and Chromatography
- Diet, Metabolism, and Disease
- Cannabis and Cannabinoid Research
- Pancreatic function and diabetes
- Plant Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- GABA and Rice Research
- Protein purification and stability
- Gut microbiota and health
- Carbohydrate Chemistry and Synthesis
- Diet and metabolism studies
- Algal biology and biofuel production
- Endoplasmic Reticulum Stress and Disease
- Plant biochemistry and biosynthesis
- Dietary Effects on Health
- Mercury impact and mitigation studies
- Plant Molecular Biology Research
- Bioactive natural compounds
- Blood Pressure and Hypertension Studies
- Research in Cotton Cultivation
- Healthcare Systems and Practices
Laboratoire de Biogenèse Membranaire
2009-2024
Centre National de la Recherche Scientifique
2010-2024
Université de Bordeaux
2003-2023
Institut Polytechnique de Bordeaux
2017-2021
École Normale Supérieure - PSL
2004
Laboratoire des Biomolécules
2003
Laboratoire de Génie Chimique
1997-2001
Laboratoire Sols et Environnement
1995-1998
Université de Lorraine
1995-1997
Metabolic disorders, including obesity, diabetes, and cardiovascular disease, are widespread in Westernized nations. Gut microbiota composition is a contributing factor to the susceptibility of an individual development these disorders; therefore, altering person’s may ameliorate disease. One potential microbiome-altering strategy incorporation modified bacteria that express therapeutic factors into gut microbiota. For example, N-acylphosphatidylethanolamines (NAPEs) precursors...
Lipid droplets (LDs) are cell compartments specialized for oil storage. Although their role and biogenesis relatively well documented in seeds, little is known about composition, structure function senescing leaves where they also accumulate. Here, we used a label free quantitative mass spectrometry approach to define the LD proteome of aging Arabidopsis leaves. We found that its composition highly different from seed/cotyledon identified 28 proteins including 9 enzymes secondary metabolism...
Abstract Cytoplasmic lipid droplets (LDs) are evolutionarily conserved organelles that store neutral lipids and play critical roles in plant growth, development, stress responses. However, the molecular mechanisms underlying their biogenesis at endoplasmic reticulum (ER) remain obscure. Here we show a recently identified protein termed LD-associated [LDAP]-interacting (LDIP) works together with both reticulum-localized SEIPIN LD-coat LDAP to facilitate LD formation Arabidopsis thaliana....
Objective. The aim was to analyse the accuracy of a hand dynamometer connected smartphone assess RA disease activity through measurement handgrip strength (HGS). Methods. Eighty-two patients participated in this prospective study. Three types HGS were assessed: power (Po), pinch (Pi) and tripod (T). An interactive mobile application developed capture grip measures. A unilinear regression analysis between DAS28 performed. multivariate identify independent variables related also conducted....
When the yeast protein Ypr140w was expressed in Escherichia coli, a lyso-PC [lysophosphatidylcholine (1-acylglycerophosphorylcholine)] acyltransferase activity found associated with membranes of bacteria. To our knowledge, this is first identification capable catalysing acylation molecules to form PC. Fluorescence microscopy analysis living yeasts revealed that fusion Ypr140w–green fluorescent targeted mitochondria. Moreover, contrast wild-type cells, absence acyl-CoA, mutant deleted for...
In yeast, both phosphatidylinositol and phosphatidylserine are synthesized from cytidine diphosphate-diacylglycerol. Because, as in other eukaryotes, contains more saturated fatty acids than (and phospholipids), it has been hypothesized that either is distinct diphosphate-diacylglycerol molecules, or that, after its synthesis, modified by a hypothetical acyltransferase incorporates acid into neo-synthesized molecules of phosphatidylinositol. We used database search methods to identify an...
<i>N</i>-Acylethanolamines (NAEs) are lipids involved in several physiological processes animal and plant cells. In brain, NAEs ligands of endocannabinoid receptors, which modulate various signaling pathways. plant, regulate seed germination root development, they defense against pathogen attack. This activity is started by an enzyme called <i>N</i>-acylphosphatidylethanolamine (NAPE) synthase. catalyzes the <i>N</i>-acylation phosphatidylethanolamine to form NAPE, most likely hydrolyzed...
Eukaryotic Δ6-desaturases are microsomal enzymes that balance the synthesis of ω-3 and ω-6 C18-polyunsaturated fatty acids (C18-PUFAs) according to their specificity. In several microalgae, including Ostreococcus tauri, plastidic C18-PUFAs strictly regulated by environmental cues suggesting an autonomous control Δ6-desaturation PUFAs. Here, we identified two putative front-end Δ6/Δ8-desaturases from O. tauri that, together with homologs, cluster apart other characterized Δ6-desaturases. Both...
Abstract Upon abiotic stress or senescence, the size and/or abundance of plastid-localized plastoglobules and cytosolic lipid droplets, both compartments devoted to neutral storage, increase in leaves. Meanwhile, plant metabolism is also perturbed, notably with degradation thylakoidal monogalactosyldiacylglycerol (MGDG) accumulation lipids. Although these mechanisms are probably linked, they have never been jointly studied, respective roles droplets response totally unknown. To address this...