A5021086953- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Biochemical and Molecular Research
- Microtubule and mitosis dynamics
- Mentoring and Academic Development
- Health and Medical Research Impacts
- Healthcare professionals’ stress and burnout
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
Johns Hopkins University
2021-2025
Johns Hopkins Medicine
2025
Stanford University
2021
Abstract Problem All trainees, especially those from historically minoritized backgrounds, experience stresses that may reduce their continuation in science, technology, engineering, math, and medicine (STEMM) careers. The Johns Hopkins University School of Medicine is one ∼45 institutions with a National Institutes Health funded Postbaccalaureate Research Education Program (PREP) provides mentoring year fulltime research to prepare students excluded groups for graduate school. Having...
Summary The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a global health threat necessitating the development new antibiotics. Serine hydrolases (SHs) are promising class targets because their importance for synthesis mycobacterial cell envelope. We screened library small molecules containing serine-reactive electrophiles and identified narrow spectrum inhibitors M. tuberculous growth. Using these lead molecules, we performed competitive...
The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a global health threat necessitating the development new antibiotics. Serine hydrolases (SHs) are promising class targets because their importance for synthesis mycobacterial cell envelope. We screened library small molecules containing serine-reactive electrophiles and identified narrow spectrum inhibitors M. tuberculous growth. Using these lead molecules, we performed competitive activity-based...