A5040666131- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Tracheal and airway disorders
- Quinazolinone synthesis and applications
- Asthma and respiratory diseases
- Antifungal resistance and susceptibility
- Respiratory viral infections research
- Tuberous Sclerosis Complex Research
- Infective Endocarditis Diagnosis and Management
- Eosinophilic Disorders and Syndromes
- Inhalation and Respiratory Drug Delivery
- Transplantation: Methods and Outcomes
- Chronic Disease Management Strategies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Olfactory and Sensory Function Studies
- Folate and B Vitamins Research
- Sinusitis and nasal conditions
- Biochemical Analysis and Sensing Techniques
- Dysphagia Assessment and Management
- Interprofessional Education and Collaboration
- Advanced Chemical Sensor Technologies
- Advanced Drug Delivery Systems
- Microwave-Assisted Synthesis and Applications
University of Pennsylvania
2010-2025
Pulmonary and Allergy Associates
2020-2023
Washington University in St. Louis
2022
Hospital of the University of Pennsylvania
2013-2020
Seattle University
2015
Seattle Children's Hospital
2015
Lengthy, multidrug, toxic, and low-efficacy regimens limit management of pulmonary nontuberculous mycobacterial disease.In this phase II study, we investigated the efficacy safety liposomal amikacin for inhalation (LAI) in treatment-refractory (Mycobacterium avium complex [MAC] or Mycobacterium abscessus) disease.During double-blind phase, patients were randomly assigned to LAI (590 mg) placebo once daily added their multidrug regimen 84 days. Both groups could receive open-label additional...
Background Chronic rhinosinusitis (CRS) is very prevalent in the cystic fibrosis (CF) patient population, and leads to high morbidity markedly decreased quality of life (QOL). Identification genetic markers that contribute CRS symptoms these patients can allow for risk stratification tailoring medical surgical treatments. T2R38 a bitter taste receptor expressed sinonasal tract, nonfunctional alleles this have been implicated treatment‐refractory non‐CF patients. The purpose study investigate...
Rationale: People with cystic fibrosis (CF) experience acute worsening of respiratory symptoms and lung function known as pulmonary exacerbations. Treatment intravenous antimicrobials is common; however, there scant evidence to support a standard treatment duration. Objectives: To test differing durations for CF Methods: STOP2 (Standardized Pulmonary Exacerbations 2) was multicenter, randomized, controlled clinical trial in exacerbations among adults CF. After 7-10 days treatment,...
BACKGROUND. Several molecular imaging strategies can identify bacterial infections in humans. PET affords the potential for sensitive infection detection deep within body. Among PET-based approaches, antibiotic-based radiotracers, which often target key bacterial-specific enzymes, have considerable promise. One question antibiotic radiotracers is whether antimicrobial resistance (AMR) reduces specific accumulation bacteria, diminishing predictive value of diagnostic test.
Abstract Background Patients with refractory Mycobacterium avium complex lung disease (rMACLD) represent a difficult to treat population, who have not achieved culture conversion (CC) despite prolonged treatment multidrug antibacterial regimen (MDR). In the CONVERT trial, amikacin liposome inhalation suspension (ALIS) + MDR resulted in higher CC rates than alone during first 6 months of (29% vs 9%) patients that had positive cultures on for at least months. Adverse events (AEs) following...
Rationale: The clinical significance of Aspergillus fumigatus (Af) detection in the absence allergic bronchopulmonary aspergillosis cystic fibrosis (CF) airways remains unclear. Yet, some clinicians initiate antifungal therapy for Af-positive respiratory cultures out concern infection people with CF. Objectives: To determine association between presence Af and outcomes individuals Methods: We conducted a prospective longitudinal cohort study 206 adults adolescents (age 14 yr older) CF...
Despite advances in medical care, patients with cystic fibrosis still face limited life expectancy. The most common cause of death remains respiratory failure. End-stage can be treated lung transplantation and is the third reason for which procedure performed. Outcomes are better than other diseases, but remain (5-year survival 60%). For advanced disease appears to improve survival. Burkholderia cepacia poor, although they certain genomovars. Controversy exists about Mycobacterium abscessus...
Cystic fibrosis (CF) is one of the most common autosomal recessive lethal disorders affecting white populations northern European ancestry. To date there no cure for CF. Life-long treatments CF are being developed and include gene therapy use small-molecule drugs designed to target specific cystic transmembrane conductance regulator (CFTR) mutations. Irrespective type molecular CF, which may replacement, exon skipping, nonsense suppression, or correctors, because all these modulate...
Abstract Background Rapidly growing mycobacteria (RGM) have high rates of intrinsic antibiotic resistance and require prolonged therapies associated with considerable toxicity. Less toxic more effective are needed. One promising agent is clofazimine (CFZ), an favorable in vitro data but limited clinical RGM. Methods We performed a retrospective cohort study all patients treated for RGM infection CFZ-containing regimen the University Pennsylvania Health System between 1/1/2010 12/31/2016....
Abstract Recently, several molecular imaging strategies have developed to image bacterial infections in humans. Nuclear approaches, specifically positron emission tomography (PET), affords sensitive detection and the ability non-invasively locate deep within body. Two key radiotracer classes arisen: metabolic approaches targeting specific biochemical transformations, antibiotic-based that inherent selectivity for bacteria over mammalian cells. A critical question clinical application of...
A 42-year-old woman presented to the ED with a 3-day history of shortness breath, fatigue, and cough productive thick, yellow-green sputum. She also reported having low-grade fevers chills.