A5048825870- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Virology and Viral Diseases
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Ultrasound in Clinical Applications
- Digital Mental Health Interventions
- Retinal and Optic Conditions
- Cardiac, Anesthesia and Surgical Outcomes
- Malaria Research and Control
- Child Nutrition and Feeding Issues
- Interpreting and Communication in Healthcare
- Migration, Health and Trauma
- Radiology practices and education
- Emergency and Acute Care Studies
- Insect symbiosis and bacterial influences
- Opioid Use Disorder Treatment
- Stroke Rehabilitation and Recovery
- Substance Abuse Treatment and Outcomes
- Pediatric health and respiratory diseases
- Ocular Infections and Treatments
- Clinical Nutrition and Gastroenterology
- Cardiac Arrest and Resuscitation
- Cancer-related gene regulation
Columbia University Irving Medical Center
2024
Emory University
2022-2023
University Medical Center
2022-2023
Carilion Clinic
2019-2021
Virginia Tech
2019-2021
Biomedical Research Institute
2019
University of Wisconsin–Madison
2016-2018
Abstract Infection with Asian-lineage Zika virus (ZIKV) has been associated Guillain–Barré syndrome and fetal abnormalities, but the underlying mechanisms remain poorly understood. Animal models of infection are thus urgently needed. Here we show that rhesus macaques susceptible to by an ZIKV closely related strains currently circulating in Americas. Following subcutaneous inoculation, RNA is detected plasma 1 day post (d.p.i.) all animals ( N =8, including 2 pregnant animals), also present...
Infection with Zika virus (ZIKV) is associated human congenital fetal anomalies. To model outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals a previous study contemporary the current report clear viremia within 10–12 days, maternal was prolonged 3 of 4 pregnancies. Fetal head growth velocity last month gestation determined by ultrasound assessment circumference decreased comparison biparietal diameter...
Background Zika virus (ZIKV; Flaviviridae, Flavivirus) was declared a public health emergency of international concern by the World Health Organization (WHO) in February 2016, because evidence linking infection with ZIKV to neurological complications, such as Guillain-Barre Syndrome adults and congenital birth defects including microcephaly developing fetus. Because development vaccine is top research priority genetic antigenic variability many RNA viruses limits effectiveness vaccines,...
The specificity of the antibody response against Zika virus (ZIKV) is not well-characterized. This due, in part, to antigenic similarity between ZIKV and closely related dengue (DENV) serotypes. Since these other similar viruses co-circulate, are spread by same mosquito species, can cause acute clinical syndromes, it difficult disentangle ZIKV-specific responses from closely-related arboviruses humans. Here we use high-density peptide microarrays profile anti-ZIKV reactivity pregnant...
Summary Zika virus (ZIKV) isolates are genetically diverse, but belong to two recognized lineages, termed “African” and “Asian.” Asian ZIKV infection during pregnancy causes fetal abnormalities including microcephaly. Developing an effective preventative vaccine that protects pregnant women is essential for minimizing abnormalities; at least 18 groups developing vaccines (Hayden, 2016). The genetic antigenic variability of many RNA viruses limits the effectiveness vaccines, degree which...
Abstract The Ikaros zinc-finger transcription factor Eos has largely been associated with sustaining the immunosuppressive functions of regulatory T cells. Paradoxically, more recently implicated in promoting proinflammatory responses dysregulated setting autoimmunity. However, precise role regulating differentiation and function effector CD4+ cell subsets remains unclear. In this study, we find that is a positive regulator murine TH2 cells, an population both immunity against helminthic...
Infection with Asian lineage Zika virus has been associated Guillain-Barré syndrome and fetal abnormalities 1–4 , but the mechanisms risk factors for these outcomes remain unknown. Here we show that rhesus macaques are susceptible to infection by an Asian-lineage closely related strains currently circulating in Americas. Following subcutaneous inoculation, RNA was detected plasma one day post-infection (dpi) all animals (N = 8, including 2 infected during first trimester of pregnancy)....
Stop the Bleed (STB), and other trainings that promote health education in basic trauma management techniques, is offered mostly English Spanish United States. Limited access to injury prevention training may contribute inequities outcomes for individuals with limited proficiency (LEP). Our study aims determine feasibility effectiveness of STB 4 languages spoken a super diverse refugee settlement community, Clarkston, GA.Written educational materials were culturally adapted, translated, back...
Abstract Background Clinical trials provide consistent evidence for buprenorphine’s efficacy in treating opioid use disorder (OUD). While the Drug Addiction Treatment Act of 2000 requires physicians to combine medication-assisted treatment (MAT) with behavioral intervention, there is no clear what form or elements psychotherapy are most effective when coupled MAT treat OUD. This investigation involves focus groups designed collect patient opinions about a specific psychotherapy, called START...
Abstract The specificity of the antibody response against Zika virus (ZIKV) is not well-characterized. This due, in part, to antigenic similarity between ZIKV and closely related dengue (DENV) serotypes. Since these other similar viruses co-circulate, are spread by same mosquito species, can cause acute clinical syndromes, it difficult disentangle ZIKV-specific responses from closely-related arboviruses humans. Here we use high-density peptide microarrays profile anti-ZIKV reactivity...
Abstract The Ikaros zinc finger transcription factor Eos has largely been associated with chromatin regulation promoting immunosuppressive regulatory T cells. However, Eos’ role in the differentiation and function of pro-inflammatory cells remained unclear. Surprisingly, our work reveals that is a positive regulator CD4 +T helper 2 (T H2) cells—effector participate anti-helminthic immunity but are also implicated inducing allergic asthma. Using vitro-generated H2 an vivo asthma mouse model,...
Aim: The aim of the study is to determine pattern and complications vernal-keratoconjunctivitis. Study design: This a retrospective observational study. Duration setting study: was done on patients presenting private ophthalmologist's clinic in Peshawar over period fifteen months from July 2017 October 2018. Methods: Patient consent not required. During research, principles Helsinki declaration were strictly adhered to. Results: In this we evaluated 1180 suffering vernal-...
Abstract CD4+ T cells differentiate in response to specific cytokine environments that induce the activation of STAT transcription factors and, ultimately, cell-specific gene profiles. The differentiation TH2 requires cytokines IL-4 and IL-2, which signal via STAT6 STAT5, respectively. Interestingly, signaling IL-2/STAT5 axis is also required for TH1 cell type. Our lab recently found IL-2 induces expression Ikaros Zinc Finger (IkZF) factor Eos (Ikzf4) cells, positively regulates TH1-specific...
Abstract TH17 cells are a subset of T helper involved in mucosal immunity that defined, part, by their production the proinflammatory cytokine IL-17. Dysregulated Th17 have been implicated several autoimmune diseases, such as multiple sclerosis and inflammatory bowel disease. Therefore, there is substantial interest understanding mechanisms underlying differentiation function. development requires signals from IL-6 to activate STAT3, which positively regulates expression genes including...
This low-cost peritonsillar abscess model is intended for the education of emergency medicine and otolaryngology residents advanced care practitioners all training levels.With incidence rates as high 124 per 100,000 in 14-21 age range, abscesses (PTA) are one more common head neck soft tissue infections encountered department.1 Peritonsillar can present to department critically ill patients with dangers airway compromise further local spreading. Emergency (EM) need practice properly identify...
Abstract The Ikaros zinc finger transcription factor Eos has been commonly implicated in regulatory T cells to promote their immunosuppressive functions. Paradoxically, a new role is emerging for promoting pro-inflammatory responses of conventional CD4 + the dysregulated setting autoimmunity. Even so, precise regulating differentiation and function healthy effector cell subsets remains unclear. Here, we find that positive regulator helper 2 (T H 2) cells—effector induction allergic asthma....