A5086469797- Pregnancy and preeclampsia studies
- MRI in cancer diagnosis
- Prenatal Screening and Diagnostics
- Neonatal and fetal brain pathology
- Pregnancy and Medication Impact
- Virology and Viral Diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Iron Metabolism and Disorders
- Antifungal resistance and susceptibility
- Maternal and fetal healthcare
- Medical Imaging Techniques and Applications
- Inflammatory mediators and NSAID effects
- Ectopic Pregnancy Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Parvovirus B19 Infection Studies
- Advanced MRI Techniques and Applications
- Bone and Joint Diseases
- Lanthanide and Transition Metal Complexes
- Fetal and Pediatric Neurological Disorders
University of Wisconsin–Madison
2016-2022
Centre Hospitalier de Tourcoing
2018
Infection with Zika virus (ZIKV) is associated human congenital fetal anomalies. To model outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals a previous study contemporary the current report clear viremia within 10–12 days, maternal was prolonged 3 of 4 pregnancies. Fetal head growth velocity last month gestation determined by ultrasound assessment circumference decreased comparison biparietal diameter...
Introduction: Measures of maternal fractional blood volume (mFBV) in the placenta holds potential to diagnose placental vasculature deficiencies. However, methods for quantitative mapping are challenging implement clinical evaluation. As a preliminary step towards human applications, this study assesses feasibility measurements using ferumoxytol enhanced variable flip angle (VFA) T1-mapping Zika-infected rhesus macaques. Methods: Seven pregnant macaques were imaged longitudinally at up 3...
Background Pregnancy complications are often associated with poor uteroplacental vascular adaptation and standard diagnostics unable to reliably quantify flow in all vessels have sensitivity early gestation. Purpose To investigate the feasibility of using 4D MRI assess total blood pregnant rhesus macaques as a precursor human studies. Study Type Retrospective study. Animal Model Fifteen healthy, ranging from 1 st trimester 3 rd Field Strength/Sequence Abdominal was performed on 3.0T scanner...
Purpose To investigate the correspondence between arterial spin labeling (ASL) flow‐sensitive alternating inversion recovery (FAIR) and ferumoxytol DCE MRI for assessment of placental intervillous perfusion. Methods Ten pregnant macaques in late second trimester were imaged at 3 T using a 2D ASL FAIR, with without outer‐volume saturation pulses used to control bolus width, 3D DCE‐MRI acquisition. The tagged/control pairs averaged, subtracted, normalized create perfusion ratio maps. Contrast...
Abstract Ferumoxytol is a superparamagnetic iron oxide nanoparticle used off-label as an intravascular magnetic resonance imaging (MRI) contrast agent. Additionally, ferumoxytol-uptake by macrophages facilitates detection of inflammatory sites MRI through ferumoxytol-induced image changes. Therefore, ferumoxytol-enhanced holds great potential for assessing vascular function and response, critical to determine placental health in pregnancy. This study sought assess the fetoplacental unit...
Background 3D chemical shift‐encoded (CSE)‐MRI techniques enable assessment of ferumoxytol concentration but are unreliable in the presence motion. Purpose To evaluate a motion‐robust 2D‐sequential CSE‐MRI for R2* and B0 mapping ferumoxytol‐enhanced MRI placenta. Study Type Prospective. Animal Model Pregnant rhesus macaques. Field Strength/Sequence 3.0T/CSE‐MRI. Assessment was compared with respiratory‐gated placental imaging 11 anesthetized animals at multiple timepoints before after...
Abstract Identification of placental dysfunction in early pregnancy with noninvasive imaging could be a valuable tool for assessing maternal and fetal risk. Dynamic contrast enhanced (DCE) magnetic resonance (MRI) can powerful interrogating placenta health. After inoculation Zika virus or sham at gestation age (GA) 45 55 days, animals were imaged up to three times GA65, GA100, GA145. DCE MRI images acquired all sessions using ferumoxytol, an iron nanoparticle-based agent, analyzed...
Abstract Infection with Zika virus (ZIKV) is associated human congenital fetal anomalies. To model outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals a previous study contemporary the current report clear viremia within 10-12 days, maternal was prolonged 3 of 4 pregnancies. Fetal head growth velocity last month gestation determined by ultrasound assessment circumference decreased comparison biparietal...
Abstract Ferumoxytol is a superparamagnetic iron oxide nanoparticle (SPION) used off-label as an intravascular magnetic resonance imaging (MRI) contrast agent. Additionally, ferumoxytol-uptake by macrophages facilitates detection of inflammatory sites MRI through ferumoxytol-induced image changes. Therefore, ferumoxytol-enhanced holds great potential for assessing vascular function and response, critical to determine placental health in pregnancy. This study sought assess the fetoplacental...