A5065646857- Neuroblastoma Research and Treatments
- Tea Polyphenols and Effects
- Cancer, Hypoxia, and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Animal Nutrition and Physiology
- Aquaculture Nutrition and Growth
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Tannin, Tannase and Anticancer Activities
- Flavonoids in Medical Research
- Phytochemicals and Antioxidant Activities
- Pesticide and Herbicide Environmental Studies
- Cancer therapeutics and mechanisms
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant tissue culture and regeneration
- Fatty Acid Research and Health
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Gut microbiota and health
- Plant Physiology and Cultivation Studies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Inflammasome and immune disorders
- Liver physiology and pathology
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
Guiyang Medical University
2025
Second Affiliated Hospital of Nanjing Medical University
2020-2024
Jiangxi University of Traditional Chinese Medicine
2024
Children's Cancer Center
2016-2023
Baylor College of Medicine
2016-2023
Fudan University
2023
Tianjin University of Science and Technology
2022
Tianjin Medical University
2022
Xinyang College of Agriculture and Forestry
2020
Pennsylvania State University
2012-2019
For many years, both preclinical and clinical studies have provided evidences to support the beneficial effects of ω-3 Polyunsaturated fatty acids (PUFAs), particularly Eicosapentaenoic acid (EPA) Docosahexaenoic (DHA) in prevention chronic diseases.However, recently, an increasing number reported adverse or contradictory PUFAs on human health.While dose experimental condition need be considered when evaluating these effects, oxidation also serves as important factor contributing...
Abstract Background Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its role in gastric cancer (GC) remains underexplored. Methods Proteomic quantification of lysine was performed human GC tissues and adjacent normal by mass spectrometry. The mRNA protein levels lactate dehydrogenase A (LDHA) were analyzed qRT-PCR western blot, respectively. expression K222-succinylated LDHA measured tissue microarray the K222...
Abstract Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells. MYCN amplification found in half of high-risk NB patients; however, no available therapies directly target MYCN. Using multi-dimensional metabolic profiling expression systems and primary patient tumors, we comprehensively characterized the landscape driven by NB. leads to glycerolipid accumulation promoting fatty acid (FA) uptake biosynthesis. We that cells expressing amplified depend highly...
Chitosan oligosaccharides (COS) have been shown to potential protective effects against colitis, but the mechanism underlying this effect has not fully elucidated. In study, COS were found significantly attenuate dextran sodium sulfate-induced colitis in mice by decreasing disease activity index scores, downregulating pro-inflammatory cytokines, and upregulating Mucin-2 levels. also inhibited levels of nitric oxide (NO) IL-6 lipopolysaccharide-stimulated RAW 264.7 cells. Importantly,...
Scope We have previously reported that the green tea catechin, (–)‐epigallocatechin‐3‐gallate (EGCG), can induce oxidative stress in oral cancer cells but exerts antioxidant effects normal cells. Here, we report these differential prooxidative are associated with sirtuin 3 (SIRT3), an important mitochondrial redox modulator. Methods and results EGCG rapidly induced mitochondria‐localized reactive oxygen species human squamous carcinoma (SCC‐25, SCC‐9) premalignant leukoplakia (MSK‐Leuk1),...
Scope The tea catechin, (–)‐epigallocatechin‐3‐gallate (EGCG), has potential cancer preventive effects. prooxidant activity of EGCG may play a role in these Methods and results Here, we report that exerted cytotoxic effects against oral cell lines (IC 50 = 83–95 μM). treatment resulted formation extracellular reactive oxygen species (ROS), however, ROS were rapidly cleared (half‐life 1.7 h). increased the production mitochondrial H 2 O SCC‐25 cells (0–6 h) before induction apoptosis....
Abstract The cytoplasmic pattern recognition receptor, absent in melanoma 2 (AIM2), detects cytosolic DNA, activating the inflammasome and resulting pro-inflammatory cytokine production pyroptotic cell death. Recent research has illuminated AIM2’s contributions to PANoptosis host defense. However, role of AIM2 acetaminophen (APAP)-induced hepatoxicity remains enigmatic. In this study, we unveil novel function as a negative regulator pathogenesis APAP-induced liver damage aged mice,...
Avocados are a nutrient-dense source of MUFAs and rich in antioxidants. have an additional LDL cholesterol (LDL-C) lowering effect beyond that observed when their substituted for SFAs, especially on small, dense (sdLDL) particles, which susceptible to vivo oxidation associated with increased risk cardiovascular disease (CVD). We investigated whether healthy diet 1 avocado daily decreased the following secondary outcomes: circulating oxidized (oxLDL) related oxidative stress markers. A...
MYCN activation is a hallmark of advanced neuroblastoma (NB) and known master regulator metabolic reprogramming, favoring NB adaptation to its microenvironment. We found that the expression main regulators molecular clock loops profoundly disrupted in MYCN-amplified patients, this disruption independently predicts poor clinical outcome. induces repressors downregulates one activators by directly binding their promoters. Ultimately, attenuates suppressing BMAL1 oscillation, thereby promoting...
Black raspberry as a functional food is potential modulator of human metabolic disease. However, the role black polyphenols (HSM) in shaping dysregulation and perturbation gut microbiota (GM) to promote lipid metabolism liver regeneration unclear. In this work, effects HSM mitigating disturbances hepatic damage induced by high-fat diet (HFD) antibiotics (Abs) mice were measured. significantly alleviated HFD-induced obesity, insulin resistance, glucose dysregulation, well activating PI3K/AKT...
Neuroblastoma (NB) is the most common extracranial solid tumor in children. Aberrant activation of non-receptor tyrosine kinases Src and c-Abl contributes to progression NB. Thus, targeting these could be a promising strategy for NB therapy. In this paper, we report that potent dual Src/Abl inhibitor bosutinib exerts anti-tumor effects on Bosutinib inhibited cell proliferation dose-dependent manner suppressed colony formation ability cells. Mechanistically, effectively decreased activity...
Neuroblastoma is the most common extracranial solid tumor in children. The ErbB family of proteins a group receptor tyrosine kinases that promote progression various malignant cancers including neuroblastoma. Thus, targeting them with small molecule inhibitors promising strategy for neuroblastoma therapy. In this study, we investigated anti-tumor effect afatinib, an irreversible inhibitor members family, on We found afatinib suppressed proliferation and colony formation ability cell lines...
Abstract Neuroblastoma (NB) arises from oncogenic disruption of neural crest (NC) differentiation. Treatment with retinoic acid (RA) to induce differentiation has improved survival in some NB patients, but not all patients respond, and most NBs eventually develop resistance RA. Loss the chromatin modifier assembly factor 1 subunit p150 (CHAF1A) promotes cell differentiation; however, mechanism by which CHAF1A drives oncogenesis remained unexplored. This study shows that gain‐of‐function...
Abstract Purpose: mTORC1 inhibitors are promising agents for neuroblastoma therapy; however, they have shown limited clinical activity as monotherapy, thus rational drug combinations need to be explored improve efficacy. Importantly, maintains both an active p53 and aberrant mTOR signaling. Experimental Design: Using orthotopic xenograft model modulating levels, we investigated the antitumor effects of inhibitor temsirolimus in expressing normal, decreased, or mutant p53, single agent...
Abstract Several cancer core regulatory circuitries (CRCs) depend on the sustained generation of DNA accessibility by SWI/SNF chromatin remodelers. However, window when is acutely essential in these settings has not been identified. Here we used neuroblastoma (NB) cells to model and dissect relationship between cell-cycle progression ATPase activity. We find that inactivation impairs coordinated occupancy non-pioneer CRC members at enhancers within 1 hour, rapidly breaking their...
// Zhenghu Chen 1, 2 , Yanling Zhao Yang Yu Jonathan C. Pang 2, 3 Sarah E. Woodfield 4 Ling Tao Shan Guan Huiyuan Zhang Shayahati Bieerkehazhi 5, 6 Yan Shi Roma Patel Sanjeev A.Vasudevan Joanna S. Yi Jodi A. Muscal Guo-Tong Xu 1 and Jianhua Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School Medicine, 200072, P. R. China Texas Children's Cancer Center, Pediatrics, Dan L. Duncan Baylor College Houston, 77030, USA Biosciences, Weiss Natural Sciences, Rice...
Abstract Background Acetaminophen (APAP) overdose causes hepatotoxicity and even acute liver failure. Recent studies indicate that sterile inflammation innate immune cells may play important roles in damage-induced hepatocytes regeneration repair. The scavenger receptor CD36 has its crucial functions inflammation. However, the of APAP induced injury remain unclear warrant further investigation. Methods WT C57BL/6 J −/− mice were intraperitoneally injected with (300 mg/kg) after fasting for...
Effects of defatted microalgae (DFA) on fatty acid composition eggs and tissues hens have not been well studied. This experiment was to determine how low concentrations supplemental DFA in the presence or absence flaxseed oil (FO) altered profiles egg yolk, liver, adipose tissue, plasma layers. A total 60 Shaver Leghorn layer (individually caged, 20-wk old) were allotted into 6 groups (n = 10) fed a corn/soybean meal basal diet containing 0, 3, 5% 0 (1.5% corn oil, CO) 1.5% FO for wk. BW,...