A5102705095- Organ and Tissue Transplantation Research
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- Gestational Trophoblastic Disease Studies
- Maternal and fetal healthcare
- Endometriosis Research and Treatment
- Prenatal Screening and Diagnostics
- HIV/AIDS Research and Interventions
- Organ Donation and Transplantation
- Cancer Risks and Factors
- Ectopic Pregnancy Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Reconstructive Surgery and Microvascular Techniques
- Acute Myocardial Infarction Research
- Congenital Diaphragmatic Hernia Studies
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Gynecological conditions and treatments
- Maternal and Perinatal Health Interventions
- Reproductive Biology and Fertility
- Syphilis Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Telomeres, Telomerase, and Senescence
Imperial College Healthcare NHS Trust
2016-2025
Hammersmith Hospital
2011-2024
Imperial College London
2010-2024
Chelsea and Westminster Hospital
1996-2023
Queen Charlotte's and Chelsea Hospital
2012-2023
Mayo Clinic in Arizona
2016
Imperial Valley College
2015
New York University
2004-2015
Lower Manhattan Hospital
2004-2007
London Cancer
2007
Abdominal radical trachelectomy is a fertility‐preserving alternative to hysterectomy or chemoradiation for young women with stage IA2 IB cervical cancers. Thirty‐three patients were offered this procedure. The mean age was 30.5 years (range 23–37). Three procedures abandoned because of positive pelvic nodes (two patients) and involvement the margin between amputated cervix uterine fundus (one patient). Of remaining 30 patients, 10 had tumours, 15 IB1 5 IB2. During follow up median 47 months...
The multiple-dose pharmacokinetics of ritonavir were investigated in four groups human immunodeficiency virus-positive male subjects (with 16 per group) under nonfasting conditions; a 3:1 ritonavir:placebo ratio was used. Ritonavir given at 200 (group I), 300 II), 400 III), or 500 IV) mg every 12 h for 2 weeks. moderately dose dependent, with the clearance group IV (6.8 +/- 2.7 liters/h) being an average 32% lower than that I (10.0 3.2 liters/h). First-pass metabolism should be minimal...
Individual human diploid cells plated at low cell density and incubated for 2 weeks develop into colonies ranging in size from one to several thousand cells. The resultant colony distribution is an accurate indicator of the number subsequent vitro population doublings that can be attained by parent culture. This relationship holds both fetal lung adult skin fibroblast cultures. In addition, distributions obtained fetal, young adult, old cultures same level passage are indicative vivo age...
In Brief BACKGROUND: For 10,000–40,000 women each year, cervical cancer complicates pregnancy. Current therapy usually terminates the pregnancy and results in loss of future fertility. Abdominal radical trachelectomy is a fertility-preserving alternative to hysterectomy for young with cancer. CASES: We report five pregnancies complicated by treated abdominal preservation concurrent birth two healthy term infants. CONCLUSION: Pregnancy can be managed during while preserving Radical preserve fertility
This was a retrospective analysis of postpartum emergency hysterectomy performed between 1988-2003, to study incidence indicators, risk factors and complications. We included any women who required control major haemorrhage (PPH) after delivery, following pregnancy at least 24 weeks' gestation, regardless the mode delivery. excluded cases that for gynaecological reasons. There were 18 (14 caesarean four hysterectomy, vaginal delivery), giving rate 0.36/1,000 deliveries. Overall, most common...
<h3>Objective</h3> Invasive cervical cancer is one of the most common cancers, with 500,000 new cases diagnosed annually. Fertility preservation has become an important component overall quality life many survivors. Expert opinion suggested that fertility-sparing surgery should be limited to those patients less than 2 cm in diameter. Our objective was report our abdominal radical trachelectomy (ART) experience opposite group patients—those a more <h3>Methods</h3> Between 1999 and 2006, total...
Objective: A number of discordant couples, in whom the man is HIV positive and woman negative, wish to have children. To conceive they must abandon protected sex, posing a risk transmission so child. In such circumstances purification spermatozoa (‚sperm-washing‚) inseminate artificially has been proposed as method reducing transmission. Here we evaluate whether this does represent true reduction. Methods: Semen samples from HIV-positive patients were separated into spermatozoa, non-sperm...
To assess, in a randomized trial, the safety and accuracy of amniocentesis transabdominal chorionic villus sampling (CVS) performed at 11-14 weeks gestation, given that this time frame is increasingly relevant to early trisomy screening.We compared with CVS from 77 104 days gestation trial predominantly advanced maternal age population. Before randomization, feasibility both procedures was confirmed by ultrasonography, experienced operators under ultrasound guidance; conventional cytogenetic...
Absolute uterine factor infertility (AUFI) is a term used to describe women who cannot carry pregnancy because of the absence uterus or presence an anatomically physiologically non-functioning uterus. Causes AUFI can be categorised into congenital, such as Mayer–Rokitansky–Kuster–Hauser syndrome and acquired, due Asherman following hysterectomy treat postpartum haemorrhage, benign gynaecological disease cancer. affects one in 500 childbearing age.1 The present options acquire motherhood...
Please cite this paper as: Saso S, Ghaem‐Maghami Chatterjee J, Naji O, Farthing A, Mason P, McIndoe Hird V, Ungar L, Del Priore G, Smith J. Abdominal radical trachelectomy in West London. BJOG 2012;119:187–193. Objective Traditionally, the surgical management of invasive cervical carcinoma that has progressed beyond microinvasion been a abdominal hysterectomy. However, results loss fertility, with significant consequences for young patient. This report describes (ART) as potential...
Treatments for gynecologic cancer usually result in loss of fertility due to surgery or radical radiation therapy the pelvis. In countries with an established screening program cervical cancer, majority malignancies occur postmenopausal women. However, a substantial number affected women are childbearing age and have not completed their families. these younger women, consideration preservation may be important. This article describes fertility-sparing treatment options that currently...
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Aims of the guidelines These guidelines, drawn up by a multidisciplinary group clinicians and lay workers active in management pregnant women infected with HIV, aim to give up-to-date information on interventions reduce risk mother child transmission virus. The evidence use prevent HIV has been graded according strength data as per definitions US Agency for Health Care Policy Research [1]. Weighted combination antiretroviral therapy (ART) treatment infection se is presented BHIVA adults...
A group of experts gathered in Indianapolis December 2011 to address lingering concerns related uterus transplantation (UTn). They represent a multi-national four research teams who have worked for over 15 years on bringing UTn reality patients. Presented here are set parameters that must be considered order become an acceptable procedure the human setting. has been proposed as potential solution absolute uterine factor infertility (AUFI). Causes AUFI include congenital factors (i.e. absence...
Foreword. Acknowledgements. Introduction. Who are these patients. Historical perspective. Prevalene. Course of the disorder. Diagnosis. Treatment somatization disorder in primary care. Case studies from Clinical scripts. References. Annotated bibliography. Index.
Please cite this paper as : Saso S, Haddad J, Ellis P, Lindsay I, Sebire N, McIndoe A, Seckl M, Smith J. Placental site trophoblastic tumours and the concept of fertility preservation. BJOG 2011; DOI: 10.1111/j.1471‐0528.2011.03230.x. The standard management placental (PSTTs) is a radical hysterectomy with pelvic lymph node sampling. We present five cases to demonstrate modified Strassman procedure (MSP), which an alternative fertility‐sparing technique. Each had presumed solitary uterine...