A5101860766- Animal Nutrition and Physiology
- Livestock and Poultry Management
- Liver Disease Diagnosis and Treatment
- Genetic and phenotypic traits in livestock
- Alcohol Consumption and Health Effects
- Neurobiology and Insect Physiology Research
- Moringa oleifera research and applications
- Schizophrenia research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Sperm and Testicular Function
- Tryptophan and brain disorders
- Behavioral Health and Interventions
- Neuroscience and Neuropharmacology Research
- Physiological and biochemical adaptations
- Liver Disease and Transplantation
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Immune cells in cancer
- Bipolar Disorder and Treatment
- Livestock Management and Performance Improvement
- Neurotransmitter Receptor Influence on Behavior
- Reproductive Biology and Fertility
- Light effects on plants
- Eating Disorders and Behaviors
Beth Israel Deaconess Medical Center
2022-2025
Harvard University
2022-2025
University of Massachusetts Chan Medical School
2017-2022
National Taiwan University
2017-2021
Anand Agricultural University
2015-2021
Tata Institute of Fundamental Research
2018
National Centre for Biological Sciences
2016-2018
UPMC Hillman Cancer Center
2013
University of Pittsburgh
2013
Abasaheb Garware College
2008
Background Head and neck squamous cell carcinoma (HNSCC) has had little improvement in mortality rates decades. A clearer understanding of the HNSCC tumor microenvironment will aid finding more effective targeted therapies for this disease. Tumor‐associated fibroblasts (TAFs) are largest stromal cellular components HNSCC. Methods We isolated TAFs from clinical cases propagated vitro . The effects TAF‐secreted paracrine factors on migration, invasion, proliferation was assessed. effect growth...
Cell death and inflammation play critical roles in chronic tissue damage caused by cholestatic liver injury leading to fibrosis cirrhosis. Liver cirrhosis is often associated with kidney damage, which a severe complication poor prognosis. Interferon regulatory factor 3 (IRF3) known regulate apoptosis inflammation, but its role cholestasis remains obscure. In this study.
Objective Alcohol use in metabolic dysfunction-associated steatohepatitis (MASH) is associated with an increased risk of fibrosis and liver-related death. Here, we aimed to identify a mechanism through which repeated alcohol binges exacerbate liver injury high fat-cholesterol-sugar diet (MASH diet)-induced model MASH. Design C57BL/6 mice received either chow or the MASH for 3 months without weekly binges. Neutrophil infiltration, neutrophil extracellular traps (NETs) were evaluated. Results...
Although it is well established that the extracellular matrix affects tumour progression, not much known about various components and their effect on head neck squamous cell carcinoma (HNSCC) progression. Levels of collagen type XI α1 (colXIα1), a minor fibrillar collagen, have been shown to be increased in compared with normal tissue several cancers, including colorectal, breast, non-small lung cancer. Currently, functional significance colXIα1 understood. We examined expression levels mRNA...
Background and Aim: In today era, broiler industry facing a problem of price hiking feed broiler, also in competitive era there should be lower cost, conversion ratio, low consumption yet good body weight at marketable age. Materials Methods:Day-old commercial chicks (n=200) were distributed randomly into 5 dietary treatment groups viz.control (T 1 ), probiotic the @ 100 g/tonne 2 prebiotic 500 3 + feed, respectively 4 ) 50 250 ).The growth broilers dressing along with giblet (liver without...
The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific Interferon Regulatory Factor 3 (IRF3) neuroinflammation remains poorly understood. Here, we show that global IRF3 deficiency delays TLR4-mediated microglia and attenuates hallmark features LPS-induced inflammation such as cytokine release, microglial reactivity, astrocyte activation, myeloid cell infiltration, inflammasome activation. Moreover, expression a constitutively active...
The Drosophila circadian pacemaker consists of transcriptional feedback loops subjected to post-transcriptional and post-translational regulation. While regulatory mechanisms have been studied in detail, much less is known about control. Thus, we targeted 364 RNA binding associated proteins with interference. Among the 43 hits identified was alternative splicing regulator P-element somatic inhibitor (PSI). PSI regulates thermosensitive timeless (tim), promoting events favored at warm...
Background and aims: Granulocyte colony-stimulating factor (G-CSF) has been proposed as a therapeutic option for patients with ACLF, however clinical outcomes are controversial. We aimed at dissecting the role of G-CSF in an alcohol-induced murine model ACLF. Methods : ACLF was triggered by single alcohol binge (5 g/kg) bile duct ligation (BDL) liver fibrosis model. A subgroup mice received two (200 μg/kg) or vehicle injections prior to acute decompensation alcohol. Liver, blood brain...
Massive inflammation and liver failure are main contributors to the high mortality in alcohol-associated hepatitis (AH). In recent clinical trials, granulocyte colony-stimulating factor (G-CSF) therapy improved function survival patients with AH. However, mechanisms of G-CSF-mediated beneficial effects AH remain elusive. this study, we evaluated vivo G-CSF administration, using a mouse model treatment significantly reduced damage alcohol-fed mice even though it increased numbers...
Summary The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific Interferon Regulatory Factor 3 (IRF3) neuroinflammation remains poorly understood. Here, we show that global IRF3 deficiency delays TLR4-mediated microglia and attenuates hallmark features LPS-induced inflammation such as cytokine release, microglial reactivity, astrocyte activation, myeloid cell infiltration, inflammasome activation. Moreover, expression a constitutively...
Post-spermiogenesis membrane surface modifications rely on molecules present in the reproductive tracts. Two isoforms (isoform 1 and 2) from Quiescin Q6-Sulfydryl Oxidase protein family have been identified male tract of rodent species. However, unlike isoform 1, scarce information is available for 2, likely due to its lower expression level lack proper purification methods obtain sufficient quantity further assays. This study demonstrated presence short long forms 2 boar, representing...
Fat accumulation has been classically considered as a means of energy storage. Obese people are theorized metabolically 'thrifty', saving during times food abundance. However, recent research highlighted many neuro-behavioral and social aspects obesity, with suggestion that abdominal obesity in particular, may have evolved signal. We tested here whether body proportions, perceived signals revealing personality traits. Faceless drawings three male forms namely lean, muscular feminine, each...
Semen from the chimpanzee species becomes a colloidal solid after ejaculation. The formation of this copulatory plug is believed to prevent additional spermatozoa subsequent mating events accessing ova. However, naturally preserved strategy hampers processes for sperm preparation. In study, we investigated whether collagenase can be used degelify semen and accelerate liquefaction process in zoo captive (Pan troglodytes).
Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced have remained largely elusive though important role ascribed to 5-HT2A (Serotonin receptor subtype-2A). In this pilot study, we report the first time that 'global' knockout mice (Htr2a-/-) are resistant hyperglycemia. Importantly though, Htr2a-/- exhibit...
Ambient temperature varies constantly. However, the period of circadian pacemakers is remarkably stable over a wide-range ecologically- and physiologically-relevant temperatures, even though kinetics most biochemical reactions accelerates as rises. This thermal buffering phenomenon, called compensation, critical feature rhythms, but how it achieved remains elusive. Here, we uncovered important role played by Drosophila PERIOD (PER) phosphodegron in compensation. phosphorylation hotspot...
A flavin-dependent enzyme quiescin Q6 sulfhydryl oxidase 1 (QSOX1) catalyzes the oxidation of thiol groups into disulfide bonds. QSOX1 is prominently expressed in seminal plasma. However, its role male reproduction elusive. Here, we purified secreted form QSOX1, i.e., QSOX1c, from mouse vesicle secretions and revealed for first time function involved sperm physiology. Exogenous addition QSOX1c time-dependently promoted vitro aggregation thiol-rich, oxidative stressed, apoptotic human cells....
Severe alcohol-associated hepatitis (AH) is a life-threatening form of liver disease. Liver neutrophil infiltration hallmark AH, yet the effects alcohol on functions remain elusive. Identifying therapeutic targets to reduce neutrophil-mediated damage essential. Bruton’s tyrosine kinase (BTK) plays an important role in development and function; however, BTK AH unknown. Using RNA sequencing circulating neutrophils, we found increase Btk expression ( P = 0.05) phosphorylated (pBTK) patients...
<h3>Abstract</h3> GPCRs such as 5-HT<sub>2A</sub> and D2 are implicated in the therapeutic side effects of antipsychotics. However, pattern brain activity that leads to behavioral antipsychotics is poorly understood. To address this question, we used transgenic 'FosTRAP' mice (<i>Mus musculus</i>), where a fluorescent reporter marks cells responsive stimulus interest. Here, was an administration various antipsychotic drugs. In case typical Haloperidol, <i>c-fos</i> active were predominantly...