A5101680439- Urinary and Genital Oncology Studies
- Pituitary Gland Disorders and Treatments
- Infectious Diseases and Tuberculosis
- Regulation of Appetite and Obesity
- Bladder and Urothelial Cancer Treatments
- Chromatin Remodeling and Cancer
- Kawasaki Disease and Coronary Complications
- Neuroendocrine Tumor Research Advances
- Stress and Burnout Research
- Cardiovascular Function and Risk Factors
- Diabetes and associated disorders
- Educational Innovations and Technology
- Growth Hormone and Insulin-like Growth Factors
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Hypothalamic control of reproductive hormones
- Orthopedic Infections and Treatments
- Health and Medical Education
- Electronic Health Records Systems
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Mechanisms of cancer metastasis
- Data Quality and Management
- Hedgehog Signaling Pathway Studies
- Autoimmune and Inflammatory Disorders Research
- Orthodontics and Dentofacial Orthopedics
University of Oklahoma Health Sciences Center
2024
Hackensack University Medical Center
2023
Hospital Juan Ramón Jiménez
2023
Nationwide Children's Hospital
2021-2022
The Ohio State University
2022
Universidad de Los Andes
2022
Universidad Surcolombiana
2020-2021
Fundación Valle del Lili
2020
Fundación Universitaria Sanitas
2012-2015
Universidad Cooperativa de Colombia
2014
Somatostatin and its related peptide cortistatin exert multiple actions on normal tumoral tissue targets through a family of receptors termed somatostatin receptor (sst)1-5. Despite the considerable advances in knowledge these their (patho)physiological roles, there is still evidence that additional for peptides should exist to fully explain actions.The growing number spliced variants found similar families, often present tumors, results from our group obtained sst5 other species (pig) led...
Aims: To evaluate whether ki-67 labelling index (LI) has independent prognostic value for survival of patients with bladder urothelial tumours graded according to the 2004 World Health Organisation classification. Methods: Ki-67 LI was evaluated in 164 cases using grid counting method. Non-invasive (stage Ta) were: papilloma (n = 5), papillary neoplasia low malignant potential (PUNLMP; n 26), and (LG; 34) or high grade (HG; 15) carcinoma. Early invasive T1) LG 58) HG 26) Statistical analysis...
Abstract Since the COVID-19 pandemic began, different SARS-CoV-2 variants have been identified and associated with higher transmissibility than ancestral nonvariant strain. During January 1, 2021–January 15, 2022, we assessed differences in clinical viral parameters a convenience sample of outpatients inpatients 0–21 years age Columbus, Ohio, USA, according to infecting variant, using mutation-specific reverse transcription PCR assay. Of 676 patients study, 17.75% were infected strains,...
We studied 159 cases of superficial (stage Ta or T1) bladder tumors to determine the significance on survival a subset regulators transition from G1 S phase cell cycle (p53, p21Waf1, p27Kip1, cyclin D1, D3) and tumor proliferation (Ki-67 [MIB-1]). Clinical findings (patient age, sex, size, grade, stage [Ta T1]) were included in analysis. Univariate analysis revealed association size (P = .0353), grade ( P .0074), D1 expression .0182), Ki-67 index .0033) with disease-free .0005), .0494), D3...
OBJECTIVE Pancreatic scintigraphy with interleukin-2 radiolabeled 99mTc (99mTc-IL-2) is a technique used to image chronic inflammatory-mediated disorders. We this method detect signal consistent the presence of insulitis in patients autoimmune diabetes. Positive and negative controls (patients pancreatic carcinoma type 2 diabetes, respectively) also were studied. RESEARCH DESIGN AND METHODS examined 25 diabetes (16 recently diagnosed 1 9 latent adults [LADA]), 6 7 (the latter two groups as...
Tumour recurrence has a major impact on patients with non-invasive papillary urothelial tumours of the bladder. To explore role DBC1 (deleted in bladder cancer 1 locus), candidate tumour suppressor gene located at 9q32-33, as prognostic marker we have performed loss heterozygosity (LOH) testing 49 primary and associated normal urothelium. Data from 38 11 specimens urothelium that were informative LOH study (D9S195 marker) showed (45.4%) but not (60.5%) was (p = 0.026) to grade or...
KISS1 was originally identified as a metastasis-suppressor gene able to inhibit tumor progression. products, the kisspeptins, bind G-protein-coupled receptor (KISS1R, formerly GPR54), which is highly expressed in placenta, pituitary, and pancreas, whereas mRNA mainly hypothalamus, striatum, pituitary.KISS1/KISS1R pituitary expression profile, coupled their anti-tumoral capacities, led us hypothesize that this system may be involved biology of tumors. To explore notion, levels KISS1R were...
Background Intraoperative hypotension (IOH) is associated with increased morbidity and mortality after major abdominal surgery but remains significant even when using goal-directed hemodynamic therapy (GDHT) protocols. The Hypotension Prediction Index (HPI) a machine learning-derived parameter that predicts arterial hypotension. We tested the hypothesis an HPI-based protocol reduces duration severity of compared GDHT during surgery. Methods This parallel-arm double-blinded multicenter...
Rab proteins regulate the sequential steps of intracellular membrane transport. Alterations these GTPases and their associated are emerging as underlying cause for several human diseases involving dysregulated secretory activities.Herein we investigated role Rab18, which negatively regulates hormone secretion by interacting with granules, in relation to altered functioning tumoral pituitary somatotropes causing acromegaly.A total 18 patients diagnosed tumors acromegaly (nine patients) or...
Abstract Aim To evaluate whether renal length z ‐scores predict dysfunction in children with a solitary functioning kidney (SFK). Methods In single‐centre retrospective cohort of SFK, we correlated body mass index ‐scores, extracellular volume and lean to ‐scores. We grouped these other markers (proteinuria, hypertension, abnormal estimated glomerular function rate [eGFR]) analysed ‐score multivariate analysis, receiver‐operated characteristics (ROC) plots Youden's determine an appropriate...
Although children with COVID-19 account for fewer hospitalizations than adults, many develop severe disease requiring intensive care treatment. Critical illness due to has been associated lymphopenia and functional immune suppression. Myeloid-derived suppressor cells (MDSCs) potently suppress T are significantly increased in adults COVID-19. The role of MDSCs the response is unknown.We hypothesized that will have expansion MDSC populations compared those milder disease, higher proportions...
El tratamiento de ortodoncia con aparatos fijos altera el medio ambiente oral, aumenta la acumulacion placa, cambia composicion flora y complica limpieza para paciente. La gingivitis las lesiones mancha blanca alrededor los son efectos secundarios frecuentes cuando no se implementan programas prevencion. Los pacientes necesitan mayor orientacion profesional en seleccion productos procedimientos salud oral mas adecuados sus necesidades individuales, esto es responsabilidad del profesional.
The professional practice of the psychologist in organizations is essential addressing problems relationship between individual and work. This research aimed to describe competencies, functions areas action psychologists working organizational context. A questionnaire designed for was applied 62 belonging 45 companies Neiva (Colombia) selected under non- robabilistic criteria convenience. results show that participants work mostly private sector whose economic activity offer administrative...
The standardisation of the architecture electronic healthcare records is essential for two reasons: i) are being used to support shared care among clinicians with different specializations; ii) process eases introduction mobile technologies within and countries between people who provide receive healthcare. It a common problem previously addressed in literature that already existing EHR approaches often present interoperability issues restrain their effective application, since system...
La práctica ortodóncica reconoce la importancia de radiografía cefálica lateral, aunque en realidad limita a un análisis cuantitativo, por lo cual se realizó una revisión literatura con el fin valorar las características morfológicas que simple vista pueden ser evaluadas y son herramientas para predecir factores riesgo, pronóstico estabilidad. Se concluye lateral da visión más amplia los patrones crecimiento craneofacial, cuales modificados diversas estructuras —como base del cráneo, postura...
Abstract Atypical teratoid rhabdoid tumors (ATRT) are aggressive, malignant of the central nervous system (CNS) that develop due to a loss-of-function mutation in SMARCB1 gene. Rhabdoid tumor predisposition syndrome (RTPS) is characterized by familial cases as result pathogenic germline variants this gene and an increased risk developing ATRT within first 2 years life, which carries poor prognosis. Genetic penetrance incomplete with variable expressivity but patient's age at time diagnosis...
Abstract INTRODUCTION Rhabdoid tumors (RTs) are highly aggressive malignancies caused by a loss–of–function mutation in the SMARCB1 tumor suppressor gene on chromosome 22 that makes up SW1/SNF chromatin remodeling complex involved transcription. In rhabdoid predisposition syndrome (RTPS), biallelic germline markedly increases risk of affected individuals developing early, aggressive, and rapidly progressing RTs, most commonly CNS, referred to as atypical teratoid (AT/RT), kidneys, but...