A5100834170- Chemical Synthesis and Reactions
- Chemical Reaction Mechanisms
- Inorganic and Organometallic Chemistry
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Organoselenium and organotellurium chemistry
- Asymmetric Synthesis and Catalysis
- Organic Chemistry Cycloaddition Reactions
- Sulfur-Based Synthesis Techniques
- Coordination Chemistry and Organometallics
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
- Chemical Reactions and Mechanisms
- Synthesis and Reactions of Organic Compounds
- Synthesis and characterization of novel inorganic/organometallic compounds
- Synthetic Organic Chemistry Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of heterocyclic compounds
- Molecular spectroscopy and chirality
- Cyclopropane Reaction Mechanisms
- Radical Photochemical Reactions
- Porphyrin and Phthalocyanine Chemistry
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Reproductive Biology and Fertility
- Analytical Chemistry and Chromatography
University of Electro-Communications
1990-2024
Tokyo University of Science
2008-2022
Mie University
2022
Tokyo Medical and Dental University
2014-2021
Tokushima University
2016-2021
RIKEN Center for Brain Science
2006-2020
Tokyo Metropolitan University
2020
Niigata University
2019
Fujita Health University
2019
Nihon University
2019
Stem cells give rise to differentiated cell types but also preserve their undifferentiated state through self-renewal. With the use of transgenic mice, we found that RNA-binding protein NANOS2 is essential for maintaining spermatogonial stem cells. Lineage-tracing analyses revealed spermatogonia expressing Nanos2 self-renew and generate entire spermatogenic lineage. Conditional disruption postnatal depleted reserves, whereas mouse testes in which had been overexpressed accumulated with...
3-Nitrobenzanthrone (3-nitro-7H-benz[d,e]anthracen-7-one) was isolated from the organic extracts of both diesel exhaust and airborne particles identified as a new class powerful direct mutagen. Its mutagenicity by Ames Salmonella assay is very high (208 000 revertants/nmol in typhimurium TA98 6 290 YG1024) compares with that 1,8-dinitropyrene, which mutagen strongest activity (257 4 780 so far reported literature. The also shown to induce micronuclei mouse peripheral blood reticulocytes...
The habenular complex linking forebrain and midbrain structures is subdivided into the medial (mHb) lateral nuclei (lHb). mHb characterized by expression of specific nicotinic acetylcholine receptor isoforms release to interpeduncular nucleus (IPN), sole output region mHb. function this circuit, however, poorly understood. Here we generated transgenic mice in which cells were selectively ablated postnatally. These lesions led large reductions levels within IPN. mutant exhibited abnormalities...
A new and highly efficient method for generating mutant pigs by electroporating the CRISPR/Cas9 system into zygotes.
This review presents a systematic and comprehensive survey of various applications bismuth compounds to organic transformations. The is organized on the basis type compounds, within each reactions are transformations involved. Emphasis placed recent literature, those which authors feel have synthetic potential. Less common aspects organobismuth also included briefly.
The increasing popularity of conditional knockout (KO) technology has resulted in the demand for efficient FLP deleter mice. In addition, deleters are needed genetic backgrounds that suited to behavioral studies. We generated CAG-FLPe transgenic (Tg) mice with C57BL/6J background, which is one most commonly-used strains assessed recombination efficiency CAG-FLPe-Tg lines by crossing them a mouse line carrying FRT-PGK-neo-FRT cassette. Four five independent induced (91%-100%) their progenies,...
The early stages of ovarian follicle formation—beginning with the breakdown germ cell cysts and continuing formation primordial follicles transition to primary secondary follicles—are critical in determining reproductive life span fertility. Previously, we discovered that global knockouts cell-specific transcriptional co-regulators Sohlh1, Sohlh2, Lhx8, Nobox, cause rapid oocyte loss failure. Also factors such as Nobox Sohlh1 are associated human premature In this study, developed a...
Abstract The following polyalkylbenzenes bearing bulky groups have been subjected to direct iodination using iodine and periodic acid, the corresponding mono-iodinated products obtained in fairly high yields: 4-t-butyl-1, 2-dimethylbenzene, 5-t-butyl-1, 3-dimethylbenzene, 2, 3-trimethylbenzene, 1, 4, 5-tetraisopropylbenzene p-di-t-butylbenzene. polyiodination of polymethylbenzenes has also proceeded smoothly, giving polyiodo compounds yields. A comparison various methods proved above reagent...
Following migration of primordial germ cells to the genital ridge, oogonia undergo several rounds mitotic division and enter meiosis at approximately E13.5. Most oocytes arrest in dictyate (diplotene) stage circa E18.5. The genes necessary drive oocyte differentiation parallel with are unknown. Here, we have investigated whether expression spermatogenesis oogenesis bHLH transcription factor 1 (Sohlh1) Sohlh2 coordinates within embryonic ovary. We found that SOHLH2 protein was expressed mouse...
Abstract Embryonic implantation comprises a dynamic and complicated series of events, which takes place only when the maternal uterine endometrium is in receptive state. Blastocysts reaching uterus communicate with to implant within narrow time window. Interplay among various signalling molecules transcription factors under control ovarian hormones necessary for successful establishment pregnancy. However, molecular mechanisms that allow embryonic are still largely unknown. Here, we show...
Abstract Enamides and enimides were prepared stereospecifically from vinyl bromides by direct vinylic substitution in the presence of copper salt aprotic polar solvents.
Abstract SHP2 is a widely expressed protein tyrosine phosphatase required for signal transduction from multiple cell surface receptors. Gain and loss of function mutations in humans are known to cause Noonan LEOPARD syndromes, respectively, that characterized by numerous pathological conditions including male infertility. Using conditional gene targeting the mouse, we found maintaining spermatogonial stem cells (SSCs) production germ fertility. After deleting SHP2, spermatogenesis was halted...
Oral infection control is important for patients undergoing cardiac valve replacement (CVR) as prophylaxis postoperative complications. This study examined the changes in oral health status by preoperative periodontal treatment and its effects on postsurgical complications CVR patients.We recruited 64 who received at our hospital intervention group retrospectively reviewed medical records of 38 had undergone surgery without dental group. was assessed first visit to office, 1 day before...
Non-photochemical syntheses of optically active dimethyl[7]thiaheterohelicenes (P)-(+)-14 and (M)-(-)-14 are described. The key transformations in the metal-mediated biaryl coupling reactions between two benzodithiophene units having oxazoline moieties intramolecular McMurry reaction dialdehydes (S)-13 (R)-13. configuration atropisomer 10a obtained from was shown to be S by X-ray analysis.