A5087671347- Genetic Associations and Epidemiology
- Gastrointestinal disorders and treatments
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Statistical Methods in Clinical Trials
- Computational Drug Discovery Methods
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Single-cell and spatial transcriptomics
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Inflammatory mediators and NSAID effects
- Gut microbiota and health
- Diverticular Disease and Complications
- Optimal Experimental Design Methods
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Clostridium difficile and Clostridium perfringens research
- Genetic Mapping and Diversity in Plants and Animals
Second Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Shaanxi Blood Center
2024
Shanghai Jiao Tong University
2023-2024
Dian Diagnostics (China)
2024
Wenzhou Medical University
2024
Shaanxi Provincial People's Hospital
2024
Clinical Research Institute
2024
Columbia University
2020-2023
Xi'an Jiaotong University
2013-2023
Yale University
2023
In this study, we aimed to investigate the effects of lncRNA CASC11 on gastric cancer (GC) cell progression through regulating miR-340-5p and cycle pathway. Expressions in tissues lines were determined by qRT-PCR. Differentially expressed lncRNAs, mRNAs miRNAs screened microarray analysis. The relationship among CASC11, CDK1 was predicted TargetScan validated dual luciferase reporter assay. Western blot assay examined protein level several regulatory proteins. GO functional analysis KEGG...
<h3>Objective:</h3> To identify an improved measure of clinical progression in early Huntington disease (HD) using data from prospective observational cohort studies and placebo group randomized double-blind trials. <h3>Methods:</h3> We studied Unified Disease Rating Scale (UHDRS) non-UHDRS measures brain progressive atrophy 1,668 individuals with HD followed up prospectively for to 30 36 months longitudinal follow-up. <h3>Results:</h3> The results demonstrated that a composite motor,...
Abstract Identifying spatially variable genes (SVGs) is crucial for understanding the spatiotemporal characteristics of diseases and tissue structures, posing a distinctive challenge in spatial transcriptomics research. We propose HEARTSVG, distribution-free, test-based method fast accurately identifying large-scale transcriptomic data. Extensive simulations demonstrate that HEARTSVG outperforms state-of-the-art methods with higher $${F}_{1}$$ <mml:math...
Abstract Background The relationship between the gut mycobiome and end-stage renal disease (ESRD) remains largely unexplored. Methods In this study, we compared fungal populations of 223 ESRD patients 69 healthy controls (HCs) based on shotgun metagenomic sequencing data, analyzed their associations with host serum fecal metabolites. Results Our findings revealed that had a higher diversity in to HCs. Dysbiosis was characterized by decrease Saccharomyces cerevisiae an increase various...
Great efforts have been made to explore the potential treatment for cancers, and most common therapies include surgery, chemotherapy radiotherapy. As an alternative medication, earthworms drawn increased attention considering its abundance in resource, easy access minor side effects compared traditional therapies. However, few studies had focused on antitumor effect of earthworm-derived components. The purpose this study is investigate whether earthworm extract has tumor cell apoptosis...
Pancreatic cancer (PC) is a highly aggressive malignancy with poor prognosis, making early diagnosis crucial for improving patient outcomes. While the gut microbiome, including bacteria and viruses, believed to be essential in pathogenicity, potential contribution of virome PC remains largely unexplored. In this study, we conducted comparative analysis viral compositional functional profiles between patients healthy controls, based on fecal metagenomes from two publicly available data sets...
Abstract Irritable bowel syndrome (IBS), a chronic functional gastrointestinal disorder, is recognized for its association with alterations in the gut microbiome and metabolome. This study delves into largely unexplored domain of virome IBS patients. We conducted comprehensive analysis fecal metagenomic data set from 277 patients 84 healthy controls to characterize viral community. Our findings revealed distinct compared individuals, marked by significant variances between‐sample diversity...
Gene-based tests are valuable techniques for identifying genetic factors in complex traits. Here, we propose a gene-based testing framework that incorporates data on long-range chromatin interactions, several recent technical advances region-based tests, and leverages the knockoff synthetic genotype generation improved gene discovery. Through simulations applications to genome-wide association studies (GWAS) whole-genome sequencing multiple diseases traits, show proposed test increases power...
We propose BIGKnock (BIobank-scale Gene-based association test via Knockoffs), a computationally efficient gene-based testing approach for biobank-scale data, that leverages long-range chromatin interaction and performs conditional genome-wide knockoffs. can prioritize causal genes over proxy associations at locus. apply to the UK Biobank data with 405,296 participants multiple binary quantitative traits, show relative conventional tests, produces smaller sets of significant contain gene(s)...
Rationale: Chronic kidney disease (CKD) is a progressively debilitating condition leading to dysfunction and severe complications. While dysbiosis of the gut bacteriome has been linked CKD, alteration in viral community its role CKD remain poorly understood. Methods: Here, we characterize virome using metagenome-wide analyses faecal samples from 425 patients 290 healthy individuals. Results: associated with remarkable shift profile that occurs regardless host properties, stage, underlying...
and NBI magnifying endoscopic features, were recorded compared among the groups.Targeted biopsy histopathological examination conducted if there any abnormalities.SPSS 18.0 software was used for all statistical analysis. RESULTS:Compared with healthy controls, a significantly higher proportion of GERD patients had increased number intrapapillary capillary loops (IPCLs) (78.3% vs 20%, P < 0.05), presence microerosions (41.7% 0%, non-round pit pattern below squamocolumnar junction (88.3% 30%,...
One patient with Dieulafoy's lesion (DL) of the rectum who had a history anal receptive intercourse is described and relevant literature reviewed. DL rare in clinical practice extremely rectum. It often affects patients no cirrhosis or gastrointestinal disease occurs abrupt recurrent bleeding. Visible vessels can usually be found by endoscopy coinstantaneous treatments are essential while surgical interventions occur when necessary. The diagnosis mainly based on manifestations endoscopic...
Oxygen metabolism is an important factor affecting the development of tumors, but its roles and clinical value in Colorectal cancer are not clear. We developed oxygen (OM) based prognostic risk model for colorectal explored role OM genes cancer.Gene expression data obtained from The Cancer Genome Atlas, Clinical Proteomic Tumor Analysis Consortium databases were consider as discovery validation cohort, respectively. on differently expressed between tumor GTEx normal tissues constructed...
The effects of zerumbone on the proliferation and apoptosis esophagus cancer cells P53 Bcl-2 expression levels were studied. EC-109 cultured inoculated. effect was detected via Cell Counting Kit-8 (CCK-8) method. TdT-mediated dUTP nick end-labeling (TUNEL) staining. Moreover, mRNA reverse transcription-polymerase chain reaction (RT-PCR), protein evaluated western blotting. CCK-8 detection results showed that compared with control group, in different concentrations could inhibit activity...
Abstract Objective: To determine whether a hospital-wide universal gloving program resulted in increased hand hygiene compliance and reduced inpatient Clostridioides difficile infection (CDI) rates. Design: We carried out multiple-year before-and-after quasi-experimental quality improvement study. Gloving data as well hospital-acquired rates were prospectively collected from January 1, 2015, to December 31, 2017, by secret monitors. Settings: The University of Rochester Strong Memorial...