A5076685256- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Congenital Heart Disease Studies
- Dermatological diseases and infestations
- Neuroinflammation and Neurodegeneration Mechanisms
- Vector-borne infectious diseases
- Adenosine and Purinergic Signaling
- Cardiac Arrhythmias and Treatments
- Epilepsy research and treatment
- Renal Diseases and Glomerulopathies
- Electrochemical Analysis and Applications
- Kawasaki Disease and Coronary Complications
- PI3K/AKT/mTOR signaling in cancer
- Cardiac Structural Anomalies and Repair
- 3D Printing in Biomedical Research
- Neonatal and fetal brain pathology
- Psychosomatic Disorders and Their Treatments
- Genetics and Neurodevelopmental Disorders
- Long-Term Effects of COVID-19
- Memory and Neural Mechanisms
- Blood donation and transfusion practices
- Cardiac electrophysiology and arrhythmias
- ECG Monitoring and Analysis
- Cardiovascular and Diving-Related Complications
George Washington University
2014-2024
Children's National
2011-2024
National Research Institute
2024
Children’s Institute
2023
Mayo Clinic in Arizona
2013
Phoenix Children's Hospital
2013
University of Iowa Stead Family Children’s Hospital
2013
Children's Hospital & Medical Center
2013
Stollery Children's Hospital
2013
University of Michigan
2013
Implantable cardioverter-defibrillator (ICD) therapy in children and congenital heart disease patients is hampered by poor long-term lead survival. Lead extraction technically difficult carries substantial morbidity. We sought to determine the outcomes of ICD leads pediatric patients.The Pediatric Extractability Survival Evaluation (PLEASE) a 24-center international registry. with implantations from 2005 2010 were eligible. Study subjects comprised 878 (44% disease). Mean±SD age at...
Abstract Regenerative processes in brain pathologies require the production of distinct neural cell populations from endogenous progenitor cells. We have previously demonstrated that oligodendrocyte (OPC) proliferation is crucial for (OL) regeneration a mouse model neonatal hypoxia (HX) reproduces diffuse white matter injury (DWMI) premature infants. Here we identify histone deacetylase Sirt1 as Cdk2 regulator OPC and response to HX. HX enhances Sirt1/Cdk2 complex formation through HIF1α...
Cortical representations of different modalities can be modified by sensory learning. Our previous studies in the barrel cortex showed that expansion cortical representation a row vibrissae could induced pairing stimulation with tail shock. The plastic change reactivity to input used during training was accompanied increased density GABA immunoreactive neurons involved barrels. Using same paradigm, present study examined pathway synthesis-expression GAD67 mRNA and immunoreactivity isoenzyme...
Abstract Background: Of the children with Down syndrome 40–50% have cardiac defects and majority of these are amenable to biventricular repair. The outcome single ventricle palliation is improving; nonetheless, there limited data on patients associated high-risk factors undergoing palliation. Our aim was study outcomes pathway. Methods: A retrospective all pathway from 2005 until 2011 conducted. Operative, clinical, echocardiographic, haemodynamic data, follow-up were reviewed. Results:...
Abstract Background PECOS is an ongoing study aimed to characterize long-term outcomes following pediatric SARS-CoV-2 infection. Methods This a cross-sectional analysis of infected and uninfected cohorts at baseline. Participants (0–21 years) with laboratory-confirmed infection were enrolled as infected. Uninfected defined individuals without history or laboratory evidence Outcome measures included demographics, medical history, review symptoms, physical exam, cardiopulmonary evaluation...
Abstract Treatment of pregnant ferrets on embryonic day 24 (E24) with the antimitotic methylazoxy methanol (MAM) leads to a specific constellation effects in newborn kits, which include very thin and poorly laminated neocortex, disruption radial glial cell morphology early differentiation into astrocytes, abnormal positioning Cajal–Retzius cells. We suggest that MAM treatment E24 results this model cortical dysplasia by eliminating population cells produce factor capable maintaining glia...
Radial glia are integral components of the developing neocortex. During corticogenesis, they form an important scaffold for neurons migrating into cortical plate. Recent attention has focused on neuregulin (NRG1), acting through erbB receptors, in maintaining their morphology. We developed a model developmental radial glial disruption by delivering antimitotic [methylazoxy methanol (MAM)] to pregnant ferrets embryonic day 24 (E24). previously found that normal ferret cortex contains soluble...
A model of cortical dysplasia results from disruption the earliest generated neocortical cells. Injections an antimitotic (methylazoxy methanol — MAM) into pregnant ferrets result in a constellation effects, which include radial glia, with early differentiation astrocytes, and impaired migration neurons plate. We found previously that culture P0 MAM-treated slices explants normal plate reorganizes glia toward their morphology improves This suggested contains ‘factor’ capable providing...
Abstract Background Computational phenotypes are most often combinations of patient billing codes that highly predictive disease using electronic health records (EHR). In the case rare diseases can only be diagnosed by genetic testing, computational identify cohorts for testing and possible diagnosis. This article details validation a phenotype PTEN hamartoma tumor syndrome (PHTS) against EHR patients at three collaborating clinical research centers: Boston Children's Hospital, National...
Abstract Background Chronic red blood cell (RBC) transfusion is an established therapy to prevent stroke in patients with sickle anemia (SCA). It unclear if adding daily hydroxyurea treatment chronic beneficial. Study Design and Methods We conducted a phase 2 clinical trial (NCT03644953) investigating the addition of dose‐escalated for SCA receiving simple prevention. Simple was administered as per same protocol before after which volume transfused dependent on pretransfusion hemoglobin...
Migration of cells is a common process that leads to the development and maturation vertebrate central nervous system (Hatten, '99). The cerebral cortex consists two basic neuronal types: excitatory inhibitory. These arise in distinct areas migrate into along different routes (Pearlman et al., '98). Inhibitory interneurons tangentially from subcortical sources, mostly regions ganglionic eminences (Gelman '09; Xu '04). Their movement requires precise spatiotemporal control imposed by...
Background: Myocarditis is a rare disease involving inflammation of the myocardium which causes significant morbidity and mortality in children. Currently, endomyocardial biopsy only definitive way to diagnose myocarditis but techniques such as echocardiography cardiac MRI can be utilized aid diagnosis. New advances speckle tracking (STE) analyze myocardial strain patterns are more sensitive measure ventricular function. The primary aim this study determine if 2D imaging via STE children...
Migration of cells is a common process that leads to the development and maturation vertebrate central nervous system (Hatten, '99). The cerebral cortex consists two basic neuronal types: excitatory inhibitory. These arise in distinct areas migrate into along different routes (Pearlman et al., '98). Inhibitory interneurons tangentially from subcortical sources, mostly regions ganglionic eminences (Gelman '09; Xu '04). Their movement requires precise spatiotemporal control imposed by...