A5013472997- Entomopathogenic Microorganisms in Pest Control
- Gut microbiota and health
- Insect Pest Control Strategies
- RNA Research and Splicing
- Insect Resistance and Genetics
- Insects and Parasite Interactions
- Genomics and Phylogenetic Studies
- Vitamin D Research Studies
- Plant and Fungal Interactions Research
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Digestive system and related health
- Fungal and yeast genetics research
- Agricultural Practices and Plant Genetics
- Prion Diseases and Protein Misfolding
- Protist diversity and phylogeny
- Nematode management and characterization studies
- Microbial Metabolic Engineering and Bioproduction
- Insect Utilization and Effects
- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- Plant Gene Expression Analysis
- Alkaline Phosphatase Research Studies
- Plant tissue culture and regeneration
- Genetic diversity and population structure
St Petersburg University
2019-2025
Surgut State University
2025
Virbac (France)
2024
ITMO University
2022
Uniparental disomy is a type of chromosomal variation leading to in which both homologous chromosomes or regions are inherited from one parent. Such variations have been detected for all chromosomes. The frequency uniparental disomies estimated at 1 case per 2000 births. causes include errors during meiosis, postzygotic errors, Robertsonian and reciprocal translocations. Clinical manifestations associated with loss heterozygosity pathogenic genetic variants defects genomic...
Many higher plants contain cellular T-DNA (cT-DNA) sequences from
Amyloids are fibrillar protein aggregates with a cross-β structure. More than two hundred different proteins amyloid or amyloid-like properties already known. Functional amyloids conservative amyloidogenic regions were found in organisms. Protein aggregation appears to be beneficial for the organism these cases. Therefore, this property might orthologous proteins. The of CPEB suggested play an important role long-term memory formation Aplysia californica, Drosophila melanogaster, and Mus...
Abstract Thousands of yeast genomes have been sequenced with both traditional and long-read technologies, multiple observations about modes genome evolution for wild laboratory strains drawn from these sequences. In our study, we applied Oxford Nanopore Illumina technologies to assemble complete two widely used members a distinct lineage, the Peterhof Genetic Collection (PGC), investigate structural features including transposable element content, copy number alterations, rearrangements. We...
Background: studying the consequences of novel coronavirus infection is currently relevant. Many observations demonstrate that SARS- CoV-2 affects gastrointestinal tract, gut microbiota composition, and intestinal permeability. Aim: to assess whether Maxilac® Baby synbiotic effects qualitative quantitative composition permeability in children aged 3–14 with mild-to-moderate COVID-19. Patients Methods: an open, observational, prospective, single-center study minimal intervention was...
Spontaneous tumours in higher plants can develop depending on plant genotype without any pathogen invasion. tumour formation the taproots is consistently observed certain inbred lines of radish (Raphanus sativus var. radicula Pers.). In this work, we have sequenced genomes two closely related that differ their ability to spontaneously form tumours. We identified numerous single nucleotide variants (amino acid substitutions, insertions or deletions) are likely be associated with spontaneous...
In yeast Saccharomyces cerevisiae, there are two translation termination factors, eRF1 (Sup45) and eRF3 (Sup35), which essential for viability. Previous studies have revealed that presence of nonsense mutations in these genes leads to amplification mutant alleles (sup35-n sup45-n), appears be necessary the viability such cells. However, mechanism this phenomenon remained unclear. study, we used RNA-Seq proteome analysis reveal complete set gene expression changes occur during cellular...
Many studies have reported gut microbiome alterations in psoriasis patients, suggesting dysbiosis. While evidence for dysbiosis and its link to pathogenesis remains inconclusive, murine models of suggest that develop response psoriasis-like inflammation. Hence, the dominant narrative about alterations' impact on disease should be evaluated critically with more data a well-powered approach. In this case-control study, we used deep sequencing fecal samples from 53 patients 47 healthy donors...
A number of [PSI +]-no-more (PNM) mutations, eliminating +] prion, were previously described in SUP35. In this study, we designed and analyzed a new PNM mutation based on the parallel in-register β-structure Sup35 prion fibrils suggested by known experimental data. such an arrangement, substitution non-charged residues charged ones may destabilize fibril structure. We introduced Q33K/A34K amino acid substitutions into protein, corresponding allele was called sup35-M0. The mutagenized chosen...
Human herpes virus 6A (HHV-6A) is able to integrate into the telomeric and subtelomeric regions of human chromosomes representing chromosomally integrated HHV-6A (ciHHV-6A). The integration starts from right direct repeat (DRR) region. It has been shown experimentally that perfect repeats (pTMR) in DRR region are required for integration, while absence imperfect (impTMR) only slightly reduces frequency HHV-6 cases. aim this study was determine whether within may define chromosome which...
Bacterial microbiota in stool may vary over a wide range, depending on age, nutrition, etc. The purpose of our work was to discriminate phyla and genera intestinal bacteria their biodiversity within healthy population (North-Western Russia) compared the patients with type 1 diabetes mellitus (T1DM). study group included 183 persons 2 53 years old (a mean 26.5±1.0 old), 41 T1DM (mean age 18.2±1.8 old). disease onset at 11±1.5 years, experience 7±1.5 years. Total DNA isolated from samples,...
Amyloids are fibrillar protein aggregates with a cross-β structure and unusual features, including high resistance to detergent or protease treatment. More than two hundred different proteins amyloid amyloid-like properties already known. Several examples of nucleoporins (e.g., yeast Nup49, Nup100, Nup116, human NUP153) supposed form fibrils. In this study, we demonstrated an ability the NUP58 nucleoporin in vivo vitro. Moreover, found forms aggregates: oligomers polymers stabilized by...
(1) Hypophosphatasia (HPP) is a rare inherited disease caused by mutations (pathogenic variants) in the ALPL gene which encodes tissue-nonspecific alkaline phosphatase (TNSALP). HPP characterized impaired bone mineral metabolism due to low enzymatic activity of TNSALP. Knowledge about structure and features functions various variants, taking into account population specificity, gives an understanding hereditary nature disease, contributes diagnosis, prevention, treatment disease. The purpose...
The impact of gut microbiota on the development various diseases is great interest to researchers. However, data taxonomic diversity intestinal in chronic liver children are lacking. Purpose . To study fecal with comparison healthy patients. Material and methods A metagenomic analysis 24 (mean age 10.3 ± 4.7 years) was carried out isolation target fragment 16S rRNA gene. group included 18 autoimmune 6 non-autoimmune diseases. consisted samples 34 apparently children. Results conducted...
Yeast is a convenient model for studying protein aggregation as it known to propagate amyloid prions. [PSI+] the prion form of release factor eRF3 (Sup35). Aggregated Sup35 causes defects in termination translation, which results nonsense suppression strains carrying premature stop codons. N-terminal and middle (M) domains are necessary sufficient maintaining cells while preserving strain's properties. For this reason, Sup35NM fused fluorescent proteins often used detection investigation....
Abstract Studying aberrations of normal developmental processes like plant tumour initiation provides a great opportunity for understanding systemic control cells differentiation. Most well‐studied example is the crown gall caused by Agrobacterium tumefaciens ; much less studied are spontaneous tumours developing in plants with certain genotype, regardless agrobacterial infection. In present study, we used RNA‐seq to analyse changes gene expression at early stages development A. ‐induced...
Repetitive elements (REs) occupy a significant part of eukaryotic genomes and are shown to play diverse roles in genome regulation. During embryogenesis the sea urchin, large number REs expressed, but role these regulation biological processes remains unknown. The aim this study was identify RE expression at different stages embryogenesis. occupied 44% genomic DNA
The influence of the gut microbiota on development various diseases is great interest to researchers. conducted studies showed that in patients with chronic liver diseases, dominant taxa were Bifidobacterium longum, adolescentis, Blautia massiliensis, and healthy children — Neisseria flavescens. There no comparative analysis data taxonomic diversity intestinal autoimmune non-autoimmune children. Purpose. To investigate differences fecal as well evaluate potential biomarkers 16S rRNA gene...
Relevance. The influence of the gut microbiota on development various diseases is great interest to researchers. conducted studies showed that in patients with chronic liver diseases, dominant taxa were Bifidobacterium longum, adolescentis, Blautia massiliensis, and healthy children - Neisseria flavescens. There no comparative analysis data taxonomic diversity intestinal autoimmune non-autoimmune children. Purpose study. To investigate differences fecal as well evaluate potential biomarkers...
В настоящее время патология желудочно – кишечного тракта (ЖКТ) с аутоиммунным типом воспаления занимает высокие позиции в структуре соматической патологии. Язвенный колит (ЯК) является прогрессирующими хроническим заболеванием различных отделов кишечника. Данная встречается преимущественно у пациентов молодого и среднего возрастов, что определяет актуальность поиска новых диагностических маркеров, влияющих на своевременное начало специфической терапии, снижение резистентности к основным...