A5059282196- Reproductive Health and Technologies
- Acute Myeloid Leukemia Research
- Sociology and Education Studies
- Historical Studies on Reproduction, Gender, Health, and Societal Changes
- European history and politics
- Histone Deacetylase Inhibitors Research
- Social and Educational Sciences
- Historical Gender and Feminism Studies
- Gender Roles and Identity Studies
- German legal, social, and political studies
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- LGBTQ Health, Identity, and Policy
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Qualitative Research Methods and Ethics
- Immune Cell Function and Interaction
- Anthropology: Ethics, History, Culture
- Mast cells and histamine
- German History and Society
- German Social Sciences and History
- Gender, Security, and Conflict
- Education, Healthcare and Sociology Research
- European and International Law Studies
- Cytokine Signaling Pathways and Interactions
Karlstad University
2019-2021
Goethe University Frankfurt
2013-2019
University Hospital Frankfurt
2019
Aarhus University
2010-2017
University of Copenhagen
2014-2015
Palmetto Hematology Oncology
2013
The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether progenitor cells transformed by Hoxa9 and become addicted to targetable signaling pathways. A comprehensive (phospho)proteomic analysis revealed that increased Syk protein expression activity. upregulation occurs through a Meis1-dependent feedback loop. By dissecting this loop, we show direct target miR-146a, whose...
Significance B-cell receptor (BCR) signaling promotes the survival of malignant B cells, such as Burkitt’s lymphoma (BL) and activated B-cell–like subtype diffuse large (ABC-DLBCL). In contrast to ABC-DLBCL, which depends on chronic activation BCR, BL cells rely tonic BCR that is antigen-independent. Elucidation systematic comparison led identification novel effectors, including ACTN4 ARFGEF2, were identified regulators BL-cell survival. Beyond its relevance understanding pathogenesis...
Abstract Hypomethylating agents decitabine and azacytidine are regarded as interchangeable in the treatment of acute myeloid leukemia (AML). However, their mechanisms action remain incompletely understood, predictive biomarkers for HMA efficacy lacking. Here, we show that bioactive metabolite triphosphate, but not functions activator substrate triphosphohydrolase SAMHD1 is subject to SAMHD1-mediated inactivation. Retrospective immunohistochemical analysis bone marrow specimens from AML...
This paper, analyzing interviews with men that donate their semen in Denmark, explores what it means to be a sperm donor. Breaking the assumption have specific and clearly identifiable motivation become donors, this paper leaves confinement of such an accountable actor model implied asking for men's motivations semen. Instead, author describes experiences donors show how moral, organizational, biomedical-technological context donation Denmark makes enactments moral selves as well embodiments...
Spleen tyrosine kinase (SYK) is a nonmutated therapeutic target in acute myeloid leukemia (AML). Attempts to exploit SYK therapeutically AML have shown promising results combination with chemotherapy, likely reflecting induced mechanisms of resistance single-agent treatment vivo. We conducted genome-scale open reading frame (ORF) screen and identified activation the RAS-MAPK-ERK pathway as one major mechanism inhibitors. This finding was validated cell lines innate acquired Furthermore,...
Danish sperm donors face a particular kind of kinship trouble: they find themselves in cultural and organizational context that offers different contrary ways how to make connections donor-conceived individuals meaningful. Whereas banks law want regard these as contractual issues, the dominant narrative Denmark asks also consider them family relations. Based on interviews with participant observation at banks, I argue sense relatedness cannot be reduced either or Making connections,...
What defines the relationship between men, masculinities, and reproduction? While certainly not an easy question to answer, many people are nonetheless likely have intuitive reaction it: m...
The governance of assisted reproduction in Denmark through legislation regards semen as a reproductive substance and thus restricts donor semen’s potential by setting terms for its use. What is not addressed status an ambiguous male bodily fluid that also carries other meanings. Making into governable exchangeable happens instead on the practice level. Based qualitative interviews with Danish sperm donors ethnographic fieldwork at banks, this article explores how material-semiotic practices...
Reflecting on the troubled relationship between anthropology and military, we do so by discussing underlying epistemological, methodological, moral claims of distinction an for military. Through term ethnography things propose to reposition military as intense engagements with militarisation through empathic immersion in We develop this feminist critiques compassion, discussions critique empathy part (critical) ethnographic scholarship, anthropological debates about relationality fieldwork...
In-depth analyses of cancer cell proteomes are needed to elucidate oncogenic pathomechanisms, as well identify potential drug targets and diagnostic biomarkers. However, methods for quantitative proteomic characterization patient-derived tumors in particular their cellular subpopulations largely lacking. Here we describe an experimental set-up that allows analysis derived from either liquid or solid tumors. This is achieved by combining enrichment strategies with Super-SILAC-based mass...
In-depth analyses of cancer cell proteomes are needed to elucidate oncogenic pathomechanisms, as well identify potential drug targets and diagnostic biomarkers. However, methods for quantitative proteomic characterization patient-derived tumors in particular their cellular subpopulations largely lacking. Here we describe an experimental set-up that allows analysis derived from either liquid or solid tumors. This is achieved by combining enrichment strategies with Super-SILAC-based mass...
What are the biopolitics of masculinity? How do masculinity studies contribute to proliferation neoliberal and biopolitical governance? While one might assume that these questions imp...
THE GOOD SPERM CELL … | Questions about who has the right to be pregnant, and with whom, which children should allowed born are fundamentally political normative. However, when fertilization involves reproductive tech nologies these normative questions often translated into of quality whereby they come appear technical. This becomes clear in thework ensure “good sperm quality”. Sperm is measured both at a population level, connection fertility treatment infertile men, recruitment donors...