A5014369546- Infant Development and Preterm Care
- Cerebral Palsy and Movement Disorders
- Childhood Cancer Survivors' Quality of Life
- Parvovirus B19 Infection Studies
- Botulinum Toxin and Related Neurological Disorders
- RNA regulation and disease
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Epilepsy research and treatment
- Surgical Simulation and Training
- Single-cell and spatial transcriptomics
- Protein Tyrosine Phosphatases
- Spine and Intervertebral Disc Pathology
- Moyamoya disease diagnosis and treatment
- Trypanosoma species research and implications
- Autoimmune and Inflammatory Disorders Research
- Anatomy and Medical Technology
- Genomic variations and chromosomal abnormalities
- Augmented Reality Applications
- Ethics and Legal Issues in Pediatric Healthcare
- Histiocytic Disorders and Treatments
- Spinal Hematomas and Complications
- Vascular Malformations and Hemangiomas
- Fetal and Pediatric Neurological Disorders
- Peripheral Neuropathies and Disorders
KK Women's and Children's Hospital
2020-2025
Kyung Hee University
2024
Duke-NUS Medical School
2022-2024
Great Ormond Street Hospital for Children NHS Foundation Trust
2018
University College London
2018
Newcastle University
2018
Birmingham Children's Hospital
2018
Newcastle upon Tyne Hospitals NHS Foundation Trust
2018
Royal Hospital for Children
2014-2017
NHS Greater Glasgow and Clyde
2017
Abstract Epileptogenic triggers are multifactorial and not well understood. Here we aimed to address the hypothesis that inappropriate pro-inflammatory mechanisms contribute pathogenesis of refractory epilepsy (non-responsiveness antiepileptic drugs) in human patients. We used single-cell cellular indexing transcriptomes epitopes by sequencing (CITE-seq) reveal immunotranscriptome surgically resected epileptic lesion tissues. Our approach uncovered a microenvironment, including extensive...
To describe characteristics and course of a large UK cohort children with moyamoya from multiple centers examine prognostic predictors.Retrospective review case notes/radiology, use logistic regression to explore predictors outcome.Eighty-eight (median presentation age 5.1 years) were included. Thirty-six presented arterial ischemic stroke (AIS) 29 TIA. Eighty had bilateral 8 unilateral carotid circulation disease; patients posterior involvement. Acute infarction was present in 36/176...
ABSTRACT Introduction The Exopulse Mollii Suit is an external electrical stimulation garment that designed to reduce spasticity through of targeted muscles. Our aims were study the impact in improving gait and function children with cerebral palsy (CP). Methods Individuals aged 4–18 years spastic CP, Gross Motor Function Classification System level I–III included for a prospective single‐arm from January 2021 2022. Participants wore suit 4 weeks 60 min day. Outcome measures taken pre, post...
Abstract Introduction: Cerebral palsy (CP) is one of the most severe childhood neurodevelopmental disabilities resulting from non-progressive insult to developing brain. We aimed report our experience regarding dental visit attendance, caries prevalence and factors affecting access in children with CP Singapore. Methods: Patients diagnosed who were born or after 1994 included this study. reviewed data all 151 patients recruited under Registry Singapore (SingCPR) September 2017 May 2020. The...
Dear Sir, The advancement in genomic technologies has transformed paediatric clinical practice diagnosing genetic disorders. We present a case of 3-year-old girl with neurodevelopmental disorder an unusual cause peripheral cyanosis. By using exome sequencing, rare was diagnosed, and this ended her prolonged diagnostic odyssey. Our patient, born to non-consanguineous parents, history global developmental delay, microcephaly, epilepsy dystonia baseline axial hypertonia upper limb extensor...
Virtual Reality (VR) technology enables users to immerse themselves in computer-generated environments, providing experiences that are otherwise difficult attain real life. VR has expanded from gaming into diverse fields, even the medical sector. In education, is mainly employed for anatomy and surgical practice, enhancing learning experience by offering three-dimensional visualization interaction with human structures. This article compares various anatomical applications, including "VEDAVI...
Introduction: A voluntary cerebral palsy (CP) registry was established in 2017 to describe the clinical characteristics and functional outcomes of CP Singapore. Methods: People with born after 1994 were recruited through KK Women’s Children’s Hospital, National University Hospital Cerebral Palsy Alliance Patient-reported basic demographics, service utilisation quality life measures collected standardised questionnaires. Clinical information obtained hospital medical records. Results: Between...
Background: Dystonia is a debilitating movement disorder. Clonidine, an alpha-2 agonist, reported to be beneficial for pediatric dystonia. The use of high-dose clonidine remains poorly documented. We aimed describe our experience with clonidine. Methods: Dystonia-Severity-Action- Plan (DSAP) used evaluate the severity Results: clinical information five children, seen at KK Hospital between 2019 and 2023, on were reviewed reported. High-dose was effective in management severe exacerbations...
A previously well 13-month-old girl presented with gradual loss of ability to stand and crawl over a 2-month period. Physical examination revealed spastic paraparesis, bilateral extensor plantar responses hyperreflexia her legs. Magnetic resonance imaging the spine demonstrated an extradural tissue mass from C5 T4 causing cord compression simultaneous disease involvement T1/2 vertebral bodies. Overall, features were suspicious for neuroblastoma (Fig. 1a,b). She underwent laminoplasty biopsy...
Objectives To explore paediatric subspecialities' roles and their perceptions of the need for palliative care among children with long term neurological conditions (LTNC) compared specialists. examine ease access to healthcare services LTNC. Design Electronic questionnaire survey members BPNA, BPPM, BACD, BACCH. 24 questions evaluated different aspects practices attitudes LTNC by linear analog scale multiple choice responses. Results Total 130 respondents from specialities completed...
The growing years are paramount for bone growth and mineral accrual. Children with long-term neurological condition (LTNC) have multiple risk factors poor health fragility fractures. In Singapore, this has not been studied systematically. Therefore, we aimed to evaluate the associated fractures in children LTNC.In study, search was done by a retrospective review of patients LTNC on follow-up paediatric neurology clinic who presented fracture orthopaedic clinic. Information patients'...