A5100726745- Mosquito-borne diseases and control
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Autophagy in Disease and Therapy
- Autism Spectrum Disorder Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone health and treatments
- Anatomy and Medical Technology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Surgical site infection prevention
- Family and Disability Support Research
- Platelet Disorders and Treatments
- Multiple and Secondary Primary Cancers
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Eicosanoids and Hypertension Pharmacology
- Hemophilia Treatment and Research
- Sleep and related disorders
- Cardiovascular and Diving-Related Complications
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
- Bone and Joint Diseases
- Hippo pathway signaling and YAP/TAZ
- Infant Development and Preterm Care
- Bone health and osteoporosis research
- Dental Trauma and Treatments
University of Ulsan
2017-2024
Asan Medical Center
2017-2024
Ulsan College
2017-2024
KK Women's and Children's Hospital
2012-2024
Korea Research Institute of Chemical Technology
2023
Yeungnam University
2019-2021
Duke-NUS Medical School
2021
University of Pennsylvania
2015-2020
Asan Foundation
2019
Yahoo (United Kingdom)
2019
The efficacy of bisphosphonates for osteoporotic fracture has been consistently reported in recent randomized controlled trials (RCTs) enrolling hundreds patients. objective this study was to update knowledge on the available prevention vertebral and non-vertebral fractures.An approach "using systematic reviews" PubMed Cochrane Library taken. Twenty-four RCTs investigating effects were included final analysis. A pairwise meta-analysis conducted with a random model. Subgroup analysis...
ABSTRACT Diabetes mellitus is an established risk factor associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ). Sustained activation Nod-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome contributes to persistent inflammation and impaired cutaneous wound healing in diabetic mice human. We have recently demonstrated a compelling linkage between M1 macrophages BRONJ conditions both murine human diseases. The aim this study was determine...
During the 2015-2016 Zika virus (ZIKV) epidemic, ZIKV-associated neurological diseases were reported in adults, including microcephaly, Guillain-Barre syndrome, myelitis, meningoencephalitis, and fatal encephalitis. However, mechanisms underlying neuropathogenesis of ZIKV infection are not yet fully understood. In this study, we used an adult mouse model (Ifnar1-/-) to investigate neuroinflammation neuropathogenesis. induced expression proinflammatory cytokines, interleukin-1β (IL-1β), IL-6,...
Replacement therapy is the most common treatment for reduction of bleeding and control episodic in individuals with hemophilia. Despite proven effectiveness factor replacement therapy, repeated intravenous administration a heavy burden to
Summary Background: It is a common practice to perform inhalational induction with sevoflurane followed by intravenous cannulation in children. However, there little information regarding the time at which can be attempted safely after induction. Aim: To determine optimal for safe children induced sevoflurane. Methods: Pediatric patients aged 4–10 years receiving elective cases were recruited. General anesthesia was and oxygen via mask, then attempted. The determined use of up‐and‐down...
Purpose We performed this retrospective study to investigate the outcomes of patients with hemangioma cavernous sinus after fractionated radiotherapy. Materials and Methods analyzed 10 who were treated conventional radiotherapy between January 2000 December 2016. The median patient age was 54 years (range, 31–65 years), 8 (80.0%) female. mean volume 34.1 cm3 6.8–83.2 cm3), radiation administered a total dose 50–54 Gy daily 2 Gy. Results follow-up period 6.8 2.2–8.8 years). At last follow-up,...
To validate the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and investigate whether a modified classification better reflects prognosis.Medical records patients diagnosed with non-metastatic HPV-related OPSCC between 2010 2016 at single institution were retrospectively reviewed. HPV status was determined by immunohistochemical analysis...
Background: Muscle flaps used in reconstructive surgery are known to lose volume over time because of denervation and disuse atrophy. However, there is currently no agreement on a quantitative approach evaluating changes. Here, long-term serial measurement muscle transverse rectus abdominis musculocutaneous (TRAM) flap breast reconstruction has been conducted using the Eclipse treatment planning system. Methods: This was retrospective review medical records patients who underwent unilateral...
Biosynthesis of branched-chain amino acids (BCAAs), including isoleucine, leucine and valine, is required for survival virulence a bacterial pathogen such as Streptococcus pneumoniae. IlvC, ketol-acid reductoisomerase (E.C. 1.1.1.86) with NADP(H) Mg2+ cofactors from the pathogenic pneumoniae (SpIlvC), catalyzes second step in BCAA biosynthetic pathway. To elucidate structural basis IlvC-mediated reaction, we determined crystal structure SpIlvC at 1.69 Å resolution. The contains an asymmetric...
Despite the controversy surrounding electronic cigarette (e-cigarette) safety, global consumption has been rapidly increasing. We investigated relationship between e-cigarette use and mental health conditions in adults of various ages.We conducted a secondary data analysis aged 19 to 80 who participated first year 7th Korea National Health Nutrition Examination Survey (2016). The total number participants was 5469, including 3398 non-smokers, 1700 smokers had never used e-cigarettes, 371...
Abstract Background Transfer into the operating room, onto table and mask induction of anaesthesia are major challenges faced by children with Autistic Spectrum Disorder (ASD). In a pilot study, parents observed that perioperative transfer becomes unsafe difficult when ASD uncooperative. Method A CHILD-KIND CONCEPT mobility system comprising multi-positioning seat configurations restraining module was developed inputs from multi-disciplinary healthcare professionals ASD. To appeal to...
Dear Sir, The advancement in genomic technologies has transformed paediatric clinical practice diagnosing genetic disorders. We present a case of 3-year-old girl with neurodevelopmental disorder an unusual cause peripheral cyanosis. By using exome sequencing, rare was diagnosed, and this ended her prolonged diagnostic odyssey. Our patient, born to non-consanguineous parents, history global developmental delay, microcephaly, epilepsy dystonia baseline axial hypertonia upper limb extensor...
Abstract Background and Aim This study aimed to investigate the association between liver volume change hepatic decompensation compare risk of in patients with cirrhosis (LC) hepatocellular carcinoma (HCC) who underwent stereotactic body radiation therapy (SBRT). Methods A retrospective review SBRT‐treated HCC compensated LC without was conducted. Liver measured using auto‐segmentation software on dynamic computed tomography scans. The event defined as first occurrence refractory ascites,...
Objectives : The objective of this study was to investigate the relationship between restricted, repetitive behaviors and interests (RRBI) autistic symptoms in Korean high functioning autism spectrum disorder (ASD) children examine structure RRBI. Methods Participants included 147 ASD subjects 181 unaffected siblings. were divided into two groups based on presence domain scores version Autism Diagnostic Interview-Revised (K-ADI-R), Asperger Syndrome Scale total translated Social...
Abstract During the 2015/16 Zika virus (ZIKV) epidemic, ZIKV associated neurological diseases were reported in adults, including microcephaly, Guillain-Barre syndrome, myelitis, meningoencephalitis, and fatal encephalitis. However, mechanisms underlying neuropathogenesis of infection are not yet fully understood. In this study, we used an adult ZIKV-infection mouse model ( Ifnar1 −/− ) to investigate neuroinflammation neuropathogenesis. induced expression proinflammatory cytokines, IL-1β,...
562 Background: To evaluate the role of hepatic resection in patients with objective responses after combined transarterial chemoembolization (TACE) and radiotherapy (RT) for hepatocellular carcinoma (HCC) macroscopic vascular invasion (MVI). Methods: We retrospectively reviewed treated TACE RT as a first-line treatment HCC MVI between 2010 2015. Some underwent or liver transplantation. Surgical resectability was determined by hepatobiliary transplant surgeons multidisciplinary team cancer....
2570 Background: TIGIT is a promising emerging immunotherapeutic target. However, the specific sources of expression within tumor microenvironment are largely unknown. Here, we present an AI-powered spatial tumor-infiltrating lymphocyte (TIL) analyzer, Lunit SCOPE IO, to integrate image analysis from whole slide images with single-cell molecular profiling. Methods: We used The Cancer Genome Atlas (TCGA) RNA data across 23 cancer types (n=6,930). IO was developed, trained, and validated based...