A5081761551- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Infectious Aortic and Vascular Conditions
- Venous Thromboembolism Diagnosis and Management
- Renal Transplantation Outcomes and Treatments
- Vascular anomalies and interventions
- Organ and Tissue Transplantation Research
- Abdominal vascular conditions and treatments
- Peripheral Artery Disease Management
- Diagnosis and Treatment of Venous Diseases
- Cerebrovascular and Carotid Artery Diseases
- Pancreatic and Hepatic Oncology Research
- Organ Donation and Transplantation
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Wound Healing and Treatments
- Genetic factors in colorectal cancer
- Surgical site infection prevention
- Anesthesia and Neurotoxicity Research
- Aortic aneurysm repair treatments
University Hospital Kralovske Vinohrady
2019-2025
Charles University
2015-2025
National Institute of Cardiovascular Diseases
2019-2025
Institute of Clinical and Experimental Medicine
2005-2016
Guy's Hospital
2015
TU Dresden
2010
Universitätsklinik für Chirurgie Wien
2005
Fakultní nemocnice Bulovka
2005
Heidelberg University
2002-2005
University Hospital of Bern
2001-2002
Abstract Statins are widely used for the treatment of hypercholesterolemia. However, their inhibitory action on HMG‐CoA reductase also results in depletion intermediate biosynthetic products, which importantly contribute to cell proliferation. The aim present study was compare effects individual commercially available statins experimental pancreatic cancer. vitro (pravastatin, atorvastatin, simvastatin, lovastatin, cerivastatin, rosuvastatin and fluvastatin) viability human cancer were...
The Arteriovenous Access Stage (AVAS) classification simplifies information about suitability of vessels for vascular access (VA). It's been previously validated in a clinical study. Here, AVAS performance was tested against multiple ultrasound mapping measurements using machine learning. A prospective multicentre international study (NCT04796558) with patient recruitment from March 2021-July 2024. Demographics, risk factors, parameters, types predicted and created VA (pVA, cVA) were...
There is a lack of information and consistency in the treatment retroperitoneal malignancy involving inferior vena cava (IVC). The aim this study was to establish an expert consensus on surgical management tumours IVC. Fourteen experts participated three round Delphi project. survey conducted from 1 January 2023 15 December 2023. Consensus defined as 70% agreement with Cronbach's α 0.05. All completed first round, response rates second third rounds were 92% 86%, respectively. reached several...
Background: Hybrid endovascular and open reconstructions are used increasingly often for multilevel revascularization lower limb ischaemia. The aim was to evaluate outcomes after such procedures in a single-center non-randomized retrospective study. Patients methods: Consecutive patients with arterial disease who underwent single session hybrid were analyzed depending on the type of ischaemia revascularization. Results: 164 included median follow up time 14 months (range: 0 - 70). Indication...
Objective To evaluate the role of human macrophage metalloelastase (HME) in pancreatic cancer. Summary Background Data HME, a member matrix metalloproteinase family, possesses elastolytic activity and is critical for degradation extracellular proteins. Inasmuch as tumor invasion metastasis formation require lysis matrix, HME plays both processes. Methods expression was analyzed by Northern blot analysis, reverse transcriptase–polymerase chain reaction, Western immunohistochemistry 39 cancer...
Organ shortage leads to the increased use of expanded-criteria donor (ECD) kidneys, which contribute a higher risk delayed graft function (DGF) after transplantation. The aim this study was determine factors that may better predict DGF.Histologic assessments renal biopsy were used with other clinical variables DGF kidney total Banff score equaled sum interstitial fibrosis (CI), tubular atrophy, arteriolar hyaline thickening, fibrous intimal thickening (CV), and fraction sclerotized...
The life-saving procedures for patients in chronic renal failure (CRF) are hemodialysis (HD) or successful kidney transplantation. HD requires a properly placed and functioning vascular access, most often obtained by creating an arteriovenous fistula (AVF). long-term patency of AVFs is limited, addition to other factors, the development intimal hyperplasia process results venous wall thickening progressive occlusion. Another problem limited patency, due pseudoaneurysm, which associated with...
In Brief Background Delayed graft function (DGF) caused by ischemia/reperfusion injury (I/RI) negatively influences the outcome of kidney transplantation. This prospective single-center study characterized intrarenal transcriptome during I/RI as a means identifying genes associated with DGF development. Methods Characterization transcription profile was carried out on three sequential biopsies from respective allografts before and The intragraft expression 92 candidate measured using...
The aim of this retrospective study was to assess the success rates limb salvage, and primary secondary patency reconstructions critical ischemia (CLI) patients undergoing combined infrainguinal reconstruction intraluminal angioplasty crural arteries. In 2000-2005, with concomitant arteries performed in 30 CLI, mean age 63 years (S.D.=10); according Fontaine classification, 28 (93%) had stage IV 2 (7%) III ischemia. During follow-up 12.9 (S.D.=16.9) months, 1-year vascular seen 16 (52.6%)...
<i>Background: </i>The two preservation solutions most commonly used in human transplantation surgery are University of Wisconsin (UW) and Custodiol (histidine-tryptophan-ketoglutarate; HTK). The aim our study was to compare the protective effect UW HTK on preservation-induced injury jejunal grafts, as evaluated by histological changes (semiquantitative method) small bowel mucosal serotonin levels (as a possible new quantitative method). <i>Methods:</i> Male Wistar...
This study analyzes the role of phosphatidylserine receptor (PSR) in chronic pancreatitis.In pancreatitis, destruction parenchyma comes along with infiltration lymphocytes and macrophages. The is expressed on surface macrophages crucial for recognition engulfment apoptotic cells. In present study, we investigated this its relation to apoptosis pancreatitis.The expression localization PSR were analyzed by Northern blot analysis, RT-PCR, Western analysis immunohistochemistry. Apoptosis was...