A5010835235- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- Multiple and Secondary Primary Cancers
- Liver Disease and Transplantation
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Minimally Invasive Surgical Techniques
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Anomalies and Fetal Surgery
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Liver physiology and pathology
- Metastasis and carcinoma case studies
- Liver Disease Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Pediatric Hepatobiliary Diseases and Treatments
- Clinical Nutrition and Gastroenterology
- Renal Transplantation Outcomes and Treatments
- Appendicitis Diagnosis and Management
Military University Hospital Prague
2014-2023
Charles University
2014-2023
General University Hospital in Prague
2004-2019
Central Military Hospital
2010-2018
Ocní klinika
2018
Quinta Analytica (Czechia)
2003-2018
Nemocnice Jablonec nad Nisou
2018
Creative Research Enterprises (United States)
2018
Czech Academy of Sciences, Institute of Animal Physiology and Genetics
2012
Institute of Clinical and Experimental Medicine
2000-2005
Objectives: To critically assess centralization policies for highly specialized surgeries in Europe and North America propose recommendations. Background/Methods: Most countries are increasingly forced to maintain quality medicine at a reasonable cost. An all-inclusive perspective, including health care providers, payers, society as whole patients, has ubiquitously failed, arguably different reasons environments. This special article follows 3 aims: first, analyze countries, second, how...
A small number of common susceptibility loci have been identified for pancreatic cancer, one which is marked by rs401681 in the TERT – CLPTM1L gene region on chromosome 5p15.33. Because this characterized low linkage disequilibrium, we sought to identify whether additional single nucleotide polymorphisms (SNPs) could be related cancer risk, independently rs401681. We performed an in‐depth analysis genetic variability telomerase reverse transcriptase ( ) and RNA component TERC genes, 5,550...
Acute liver failure (ALF) is a clinical condition with very high mortality rate. Its pathophysiological background still poorly understood, which necessitates search for optimal experimental ALF models features resembling those of the human disorder. Taking into consideration reproducibility induction ALF, adequate animal size, cost animals, required time gap between insult and death animals (“therapeutic window”), potential risk to investigator other aspects, administration thioacetamide...
BACKGROUNDOne of the most notable applications for circulating tumor DNA (ctDNA) detection in peripheral blood patients with metastatic colorectal cancer (mCRC) is a long-term postoperative follow-up.Sometimes referred to as "liquid (re)biopsy" it minimally invasive procedure and can be performed repeatedly at relatively short intervals (months or even weeks).The presence disease actual extent burden (tumor mass) within patient's body monitored.This particular importance, especially when...
Benchmark comparisons in surgery allow identification of gaps the quality care provided. The aim this study was to determine thresholds for high (HAR) and low (LAR) anterior resections colorectal cancer by applying concept benchmarking.This 5-year multinational retrospective included patients who underwent resection 19 high-volume centres on five continents. Benchmarks were defined 11 relevant postoperative variables at discharge, 3 months, 6 months (for LAR). calculated two separate...
Pancreatic carcinoma is the fourth leading cause of cancer-related deaths in Czech Republic, with only a minimum patients surviving 5 years. The aetiology and molecular pathogenesis are still weakly understood. TP53 has fundamental role cell cycle apoptosis frequently mutated solid tumours, including pancreatic cancer. Based on assumption that genetic variation may affect susceptibility to cancer development, polymorphisms modulating risk be major importance. We investigated four selected...
Abstract The relationship between two measures of excess body weight, mass index (BMI) and size score, risk pancreatic cancer was examined among 574 cases 596 frequency‐matched controls from the Czech Republic Slovakia enrolled 2004 2009. Analyses using multivariable logistic regression showed an increased associated with elevated quartiles BMI at ages 20 [fourth quartile: odds ratio (OR) = 1.79, 95% confidence interval (CI): 1.23, 2.61] 40 (fourth OR 1.57, CI: 1.09, 2.27) compared to lowest...
INTRODUCTION: Human Alveolar Echinococcosis -Alveolar Hydatid disease (AE) is an omitted zoonotic infection presenting with focal liver lesions.Cause of AE a larval stage Echinococcus multilocularis tapeworms.CASE PRESENTATION: In this report extraordinary case 38 year-old female examined due to 2 tumors and pulmonary nodules described.The patient underwent surgery for suspected advanced cholangiocellular carcinoma surprisingly was found.DISCUSSION: Distinguishing intrahepatic from other...
Objectives: Pancreatic carcinoma etiology and molecular pathogenesis are weakly understood. Based on the assumption that genetic variation in carcinogen metabolism further modifies risk of exposure-related cancers, we studied association polymorphisms tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) alcohol-metabolizing genes ADH1B (Arg48His) ADH1C (Ile350Val) with pancreatic cancer risk. Methods: Polymorphisms were by allelic discrimination. Results: In a hospital-based...
Percutaneous Treatment of a Superior Mesenteric Artery Pseudoaneurysm Using Stent-GraftMiloslav Rocek1, Jan H. Peregrin1, Juraj Dutka1, Miroslav Ryska2, Frantisek Bêlina2 and Jarmila Lastovcková1Audio Available | Share
Objectives: Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies risk of exposure-related cancers, an association functional polymorphisms oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], NQO2 (Phe47Leu, rs1143684)...
The aim of this pharmacokinetic evaluation was to show the effect extra methyl group in simvastatin on esterase hydrolysis between lovastatin and male female volunteers. This study based plasma concentration-time curves pharmacokinetics with its respective active metabolite statin-β-hydroxy acid obtained from two different bioequivalence studies, each 18 females males. Results were: 1-The volunteers showed a higher yield β-hydroxy than males (p < 0.002) for both simvastatin. difference...
A safe closure technique of transluminal access is essential for the widespread application natural orifice endoscopic surgery (NOTES).To evaluate feasibility and effectiveness a novel single loop-and-clips (KING closure).An experimental survival study using female laboratory pigs was performed. gastrotomy performed standard percutaneous gastrostomy technique. peritoneoscopy with an ovariectomy then double-channel endoscope, on total 14 pigs. Two different techniques were analysed: (n = 7)...
Objectives: Extracorporeal liver support (ELS) may play a role in bridging therapy patients with acute failure (ALF). The aim of this study was to compare the influence nonbiological and biological methods on intracranial pressure (ICP) an animal model ALF. Methods: A surgical devascularization ALF pigs (35–40 kg) used. Elimination started after onset hypoglycemia. Biochemical parameters (bilirubin, ammonia, lactate, etc.) as well ICP cerebral perfusion (CPP) were monitored for 12 hours. Of...
Acute liver failure (ALF) is a clinical syndrome resulting from widespread damage of hepatocytes, with extremely high mortality rate. Urgent orthotopic transplantation was shown to be the most effective therapy for ALF but this treatment option limited by scarcity donor organs. Therefore, hepatocyte (Tx) has emerged as new therapeutical measure ALF, however, first applications proved unsatisfactory. Apparently, extensive preclinical studies are needed. Our aim examine if hepatocytes isolated...