A5060664012- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Heavy metals in environment
- Fluoride Effects and Removal
- Arsenic contamination and mitigation
- Mercury impact and mitigation studies
- Carcinogens and Genotoxicity Assessment
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Glutathione Transferases and Polymorphisms
- Environmental Justice and Health Disparities
- Alcohol Consumption and Health Effects
- Trace Elements in Health
- Genomics, phytochemicals, and oxidative stress
- Food Quality and Safety Studies
- Air Quality Monitoring and Forecasting
- Climate Change and Health Impacts
- Sulfur Compounds in Biology
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Marine and Coastal Research
- Fiber-reinforced polymer composites
- Toxic Organic Pollutants Impact
- Human Health and Disease
- Fungal Biology and Applications
Chungbuk National University
2015-2024
Chungbuk National University Hospital
2015-2024
Chung-Ang University
2021
Dankook University
2018
Chungnam National University
2010
Sungkyunkwan University
2007
In order to investigate the potential of a Sanguisorba officinalis root extract as an active ingredient for wrinkle-care cosmetics, we measured its free radical scavenging activity, elastase inhibitory expression MMP-1 (matrix metalloprotease-1) in vitro, and type I collagen synthesis normal human fibroblast cells. To isolate main components from S. extract, purified by solvent fractionation, column chromatography, recrystallization. The component was identified ziyuglycoside spectroscopic...
Abstract Abandoned metal mines and refineries are considered environmentally vulnerable areas owing to high levels of exposure heavy metals. This study examined the association between renal function indicators. We studied a total 298 participants, which 74 68 resided in low- high-exposure abandoned mine areas, respectively, with 121 refinery area 35 control area. Blood urine samples were collected from participants analyze blood lead, cadmium, creatinine urinary NAG, β2-MG. The estimated...
Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating elimination constant derived from biological half-life of methylmercury blood or hair an important part calculating guidelines intake. Thus, this study was conducted to estimate Korean adults. We used a one-compartment model with direct relationship between concentrations daily dietary intake methylmercury. quantified between-person variability population, informative priors were...
This study compares biomarker levels among environmentally vulnerable residents in Korea, the general Korean population, and Asians United States. We selected 953 exposed 204 controls from Forensic Research via Omics Markers Environmental Health Vulnerable Areas (FROM) (2021-2023), 4,239 participants fourth National Survey (2018-2020), 996 US Nutrition Examination (2017-March 2020). The analyzed biomarkers included blood urinary metals, metabolites of polycyclic aromatic hydrocarbons (PAHs),...
Lead (Pb), mercury (Hg), and cadmium (Cd) are well-known environmental pollutants. They unnecessary in the biological processes of humans. This study was performed to estimate representative background exposure levels metals by measuring concentrations whole blood Korean general population. population-based cross-sectional included 4,000 subjects (1,886 males 2,114 females) 0-83 years age 2010 2011. Adult (≥ 19 age) were collected sex- age-stratified probability method, preschool-...
Concentrations of heavy metals exceed safety thresholds in the soil near Janghang Copper Refinery, a smelter Korea that operated from 1936 to 1989. This study was conducted evaluate level exposure toxic and potential effect on health people living smelter. The included 572 adults within 4 km compared them with 413 controls group similar lifestyles rural area approximately 15 Urinary arsenic (As) did not decrease according distance smelter, regardless gender working history smelters mines....
Abstract Purpose This cross-sectional study aimed to assess the effect of environmental cadmium (Cd) exposure and essential metal imbalance on renal tubular damage oxidative stress in 979 adults living a Cd-polluted area near an abandoned copper (Cu) refinery. Methods We analyzed urinary Cd concentrations, markers, such as beta-2 microglobulin (β2-MG) N -acetyl-β- d -glucosaminidase (NAG) activity urine malondialdehyde (MDA) levels. The serum copper-to-zinc ratio (CZR) was used indicator....
Arsenic (As) is widely distributed in the environment, and humans can be exposed to As from various sources such as air, water, soil, food. This study was performed evaluate exposure levels Korean adults by measuring total urine its relation with consumption of seafood, a favorite food Korea. A 2077 were subjects; they ranged age 19 83, recruited probability sampling stratified area, sex, age. None subjects had been occupationally. We collected information about demographic characteristics,...
Several epidemiological studies have reported an association between environmental pollution and various health conditions in individuals residing industrial complexes. To evaluate the effects of from complex on human health, we performed a pooled analysis epidemiologic monitoring data for residents living near national complexes Korea. The respiratory allergic symptoms prevalence acute chronic diseases, including cancer, were used as outcome variables effects. Multiple logistic regression...
This research group (FROM) aimed to develop biomarkers for exposure environmental hazards and diseases, assess apply verify these in environmentally vulnerable areas. Environmentally areas—including refineries, abandoned metal mines, coal-fired power plants, waste incinerators, cement factories, areas with high particulate matter—along control areas, were selected epidemiological investigations. A total of 1,157 adults, who had resided over 10 years, recruited between June 2021 September...
Environmental dietary carcinogens and genetic polymorphisms in metabolic enzymes have been reported to be the risk factors for gastric cancer. This study was undertaken investigate effects of diet, N-acetyltransferase (NAT) 2 acetylation status their interaction on cancer risk. The population consisted 471 patients age- sex-matched control subjects. NAT2 genotypes were identified using single-nucleotide primer extension reaction methods. Thirty-one alleles related 12 polymorphism sites...
Background Few studies in epidemiology have evaluated the effects of gene-environment interaction on oxidative stress, even though this is an important etiologic factor lung carcinogenesis. We investigated genetic polymorphisms paraoxonase 1 (PON1), smoking, and between two cancer risk stress. Methods This study's subjects consisted 416 newly diagnosed patients equal number matched controls. The GoldenGate assay was used for genotypic analyses PON1 gene. Urinary 8-hydroxydeoxyguanosine...