A5101903586- Glycosylation and Glycoproteins Research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Oral and Maxillofacial Pathology
- Infectious Diseases and Mycology
- Proteoglycans and glycosaminoglycans research
- Carbohydrate Chemistry and Synthesis
- Nasal Surgery and Airway Studies
- Ear and Head Tumors
- Olfactory and Sensory Function Studies
- Indoor Air Quality and Microbial Exposure
- Lung Cancer Research Studies
- Neonatal Respiratory Health Research
- Galectins and Cancer Biology
- Air Quality and Health Impacts
- Biochemical Analysis and Sensing Techniques
- Bone Tumor Diagnosis and Treatments
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peptidase Inhibition and Analysis
Yeungnam University
2014-2024
Yeungnam University Medical Center
2015-2024
Chungbuk National University Hospital
2015-2024
Chungbuk National University
1999-2024
Yeungnam University College
2010-2023
Dongshin University
2021
In-Q-Tel
2019
Association for Language Learning
2019
Preventive Medicine Research Institute
2018
Medical Research Institute
2018
Interleukin-1β (IL-1β) has been implicated in the pathogenesis of inflammatory diseases airway. In this study, we investigated regulation MUC2 and MUC5AC expression their regulatory mechanisms through cyclooxygenase-2 (COX-2) prostaglandin E<sub>2</sub> (PGE<sub>2</sub>). Cells activated by IL-1β showed increased COX-2, MUC2, expressions at both mRNA protein levels. Mucin production was blocked selective COX-2 inhibitor NS398, PGE<sub>2</sub> directly induced levels a dose-dependent manner....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense single-stranded RNA (+ssRNA) that causes disease 2019 (COVID-19). The viral genome encodes twelve genes for replication and infection. third open reading frame the spike (S) gene glycoprotein interacting with specific cell surface receptor - angiotensin converting enzyme (ACE2) on host membrane. Most recent studies identified single point mutation in S gene. A leading to an amino acid substitution at codon 614...
Proinflammatory cytokines, lipopolysaccharide (LPS), and neutrophil elastase (NE) have been implicated in the induction of hypersecretion respiratory mucus. In this study, we demonstrated that interleukin-1 β (IL-1 β) increased MUC2 MUC5AC mRNA levels 2- to 3-fold a time- dose-dependent manner NCI-H292 cells. contrast, MUC5B was not significantly changed. A transcription inhibitor blocked stimulation gene expression by IL-1 β. translation did interfere with expression, whereas blocked,...
To report clinical characteristics and treatment outcomes of actinomycosis the paranasal sinus.Retrospective review.The medical records six patients with sinus between 1998 2006 were analyzed.There no immunocompromised all lesions unilateral. Only one patient had a history an oroantral fistula due to facial trauma. On CT scan, unilateral opacification maxillary focal calcified densities. All cases underwent endoscopic surgery followed by relatively short-term antibiotic administration, there...
Leptin, an adipocyte-secreted hormone that regulates food intake and metabolic response, has been recently reported to increase in the serum during inflammatory airway disease associated with mucus-hypersecretion. We investigated effects of leptin on mucin expression human epithelial cells signaling pathways. The receptor was evaluated nasal mucosa NCI-H292 cells. Leptin-induced major respiratory mucins analyzed. Mutant leptin, which acts as a antagonist, specific inhibitors extracellular...
To investigate which retinoid receptors are critical in the regulation by all-trans-retinoic acid (RA) of mucin genes MUC2, MUC5AC and MUC5B cultured normal human tracheobronchial epithelial (NHTBE) cells, we used pan-RAR-, pan-RXR- RAR- isotype (alpha, beta gamma)-selective agonists RARalpha- RARgamma-selective antagonists (RAR is RA receptor RXR X receptor). RAR-, strongly induced mRNAs a dose-dependent manner, while RARbeta-selective only weakly gene expression at very high concentrations...
Among a variety of inflammatory mediators, visfatin is proinflammatory adipocytokine associated with reactions in obesity, metabolic syndrome, chronic disease, and autoimmune disease. However, the biological role secretion major mucins human airway epithelial cells has not been reported. Therefore, this study was conducted order to investigate effect brief signaling pathway on MUC8 MUC5B expression cells. Visfatin significantly induced expression. activated phosphorylation p38 MAPK....
Reflux esophagitis, a treatment for gastric ulcers known as Ilaprazole (Ila), is not stable during storage and handling at room temperature, requiring 5 degrees Celsius. In this study, to address these issues with Ila, coformers rich in oxygen (O) hydroxyl (OH) groups capable of forming hydrogen bonds were selected. These included Xylitol (Xyl), Meglumine (Meg), Nicotinic acid (Nic), L-Aspartic (Asp), L-Glutamic (Glu). A 1:1 physical mixture Ila each coformer was prepared, the potential...
Abstract Pneumolabyrinth is a rare clinical manifestation seen in the practice of otology. It occurs usually after head trauma with temporal bone fracture. However, pneumolabyrinth without fracture very occurrence. When it occurs, diagnosed by high‐resolution computed tomography bone. Therapy for conservative treatment or an exploratory tympanotomy. Recently, we saw two cases The patients were treated management pneumolabyrinth. degree recovery from hearing loss was different each patient.
Background Few studies in epidemiology have evaluated the effects of gene-environment interaction on oxidative stress, even though this is an important etiologic factor lung carcinogenesis. We investigated genetic polymorphisms paraoxonase 1 (PON1), smoking, and between two cancer risk stress. Methods This study's subjects consisted 416 newly diagnosed patients equal number matched controls. The GoldenGate assay was used for genotypic analyses PON1 gene. Urinary 8-hydroxydeoxyguanosine...
Delphinidin is one of the anthocyanidins. It believed to have anti-inflammatory property including antioxidant, antiangiogenic, and anti-cancer properties. However, effect delphinidin in mucin-producing human airway epithelial cells has not been determined. Therefore, this study was conducted order investigate brief signaling pathway lipopolysaccharide (LPS)-induced MUC8 MUC5B expression cells.In NCI-H292 primary cultures normal nasal cells, reverse transcriptase-polymerase chain reaction...
Background Glyoxal (GO), and methylglyoxal (MGO) are among the most toxic compounds emitted by electronic cigarette (E-cig) regular tobacco smoke. Airway diseases presented mucus over production as their major pathophysiologic feature. However, effects of GO MGO on pro-inflammatory cytokines mucin expression in human nasal epithelial cells, well underlying signaling pathway, have not yet been studied. Objective This study is to determine whether induce cytokines, MUC5AC/5B via...
Understanding the function of nasal vasculature in homeostasis and pathogenesis common diseases is important. Here we describe an extensive network venous sinusoids (VSs) mouse human mucosa. The endothelium VSs expressed Prox1 (considered to be a constitutive marker lymphatic endothelium) high levels VCAM-1 exhibited unusual cell-to-cell junctions. are supported by circular smooth muscle cells (SMCs) surrounded immune cells. mucosa also showed rich supply vessels with distinctive features,...
In our study, we estimated formaldehyde exposure levels of Korean medical students during their cadaver dissection practice hours. addition, examined the prevalence rates formaldehyde-specific immunoglobulin E or G antibodies and compared results with symptoms experienced as a result exposure. There were 167 (i.e., subjects) aged 23.8+/-2.5 y (mean+/-standard deviation) control group 67 premedical 20.1+/-2.8 deviation). Concentrations in laboratory ranged from 0.194 to 11.245 mg/m3...
A benign pleomorphic adenoma is the most common tumor of salivary glands. This has potential to metastasize bone, head and neck region, visceral organs skin. Although there a few reports about metastasizing maxillary sinus in paranasal sinuses, are no metastatic sphenoid sinus. We report here on case soft palate that metastasized sinus, we briefly review relevant clinical literature. Keywords: Sphenoid sinus; Pleomorphic adenoma; Metastasis
The present study examined the effects of inducible nitric oxide synthase (iNOS) deficiency on skeletal muscle atrophy in single leg-immobilized iNOS knockout (KO) and wild-type (WT) mice. left leg was immobilized for 1 wk, right used as control. Muscle weight contraction-stimulated glucose uptake were reduced by immobilization WT mice, which accompanied with increased expression muscle. Deficiency attenuated loss reduction immobilization. Phosphorylation Akt, mTOR, p70S6K to a similar...
AIM:To evaluate the relationship among Helicobacter pylori (H.pylori ) infection, CagA status, and dietary factors with RUNX3 promoter hypermethylation. METHODS:Gastric cancer tissue samples were collected from 184 South Korean patients.All patients interviewed following a semi-quantitative food frequency questionnaire.The average frequencies of intake portion sizes 89 common items documented, total intakes calories, nutrients, vitamins, minerals calculated for each subject.DNA was extracted...
Asian sand dust (ASD) is a natural phenomenon and originates from the deserts of China known to contain various chemical biomolecular components that enhance airway inflammation. The overproduction mucins an important pathologic finding in inflammatory diseases. However, mechanism ASD on mucin production epithelial cells has not been elucidated.To investigate effect signaling pathway expressions human cells.In NCI-H292 primary cultures nasal cells, MUC8 MUC5B were investigated using reverse...
Purpose: To evaluate the efficacy and safety of once-daily ciclesonide in comparison to both levocetirizine alone, a ciclesonide/levocetirizine combination patients with seasonal allergic rhinitis (SAR) perennial (PAR).Methods: Subjects exhibiting moderate severe for longer than 1 year were randomized an open-label, 3-arm, parallel group, multicenter study.Subjects received 200 µg ciclesonide, 5 mg levocetirizine, or both.Changes from baseline until end-of-study visit (2 weeks following)...
Background Inhalation of cadmium can lead to development inflammatory airway diseases such as acute pulmonary edema and chronic obstructive disease. In diseases, expression mucins is increased, which leads increased morbidity mortality the affected patients. However, no study on effect mucin genes in epithelial cells has been reported. Therefore, this was conducted order investigate brief signaling pathway human cells. Methods mucin‐producing NCI‐H292 primary cultures normal nasal cells,...