A5082290307- Heavy Metal Exposure and Toxicity
- Heavy metals in environment
- Digestive system and related health
- Glutathione Transferases and Polymorphisms
- Fluoride Effects and Removal
- Helicobacter pylori-related gastroenterology studies
- Trace Elements in Health
- Nutrition, Health and Food Behavior
- Alcohol Consumption and Health Effects
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Gout, Hyperuricemia, Uric Acid
- Chemotherapy-induced cardiotoxicity and mitigation
- Gastric Cancer Management and Outcomes
- Phytoestrogen effects and research
- Arsenic contamination and mitigation
- Inflammasome and immune disorders
- Neuroscience and Neuropharmacology Research
- Carcinogens and Genotoxicity Assessment
- Paraoxonase enzyme and polymorphisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Mercury impact and mitigation studies
- Genomics, phytochemicals, and oxidative stress
- Analytical chemistry methods development
- Neurological Disease Mechanisms and Treatments
Chungbuk National University
2012-2024
Chungbuk National University Hospital
2015-2022
Concentrations of heavy metals exceed safety thresholds in the soil near Janghang Copper Refinery, a smelter Korea that operated from 1936 to 1989. This study was conducted evaluate level exposure toxic and potential effect on health people living smelter. The included 572 adults within 4 km compared them with 413 controls group similar lifestyles rural area approximately 15 Urinary arsenic (As) did not decrease according distance smelter, regardless gender working history smelters mines....
Abstract Purpose This cross-sectional study aimed to assess the effect of environmental cadmium (Cd) exposure and essential metal imbalance on renal tubular damage oxidative stress in 979 adults living a Cd-polluted area near an abandoned copper (Cu) refinery. Methods We analyzed urinary Cd concentrations, markers, such as beta-2 microglobulin (β2-MG) N -acetyl-β- d -glucosaminidase (NAG) activity urine malondialdehyde (MDA) levels. The serum copper-to-zinc ratio (CZR) was used indicator....
Background Few studies in epidemiology have evaluated the effects of gene-environment interaction on oxidative stress, even though this is an important etiologic factor lung carcinogenesis. We investigated genetic polymorphisms paraoxonase 1 (PON1), smoking, and between two cancer risk stress. Methods This study's subjects consisted 416 newly diagnosed patients equal number matched controls. The GoldenGate assay was used for genotypic analyses PON1 gene. Urinary 8-hydroxydeoxyguanosine...
AIM:To evaluate the relationship among Helicobacter pylori (H.pylori ) infection, CagA status, and dietary factors with RUNX3 promoter hypermethylation. METHODS:Gastric cancer tissue samples were collected from 184 South Korean patients.All patients interviewed following a semi-quantitative food frequency questionnaire.The average frequencies of intake portion sizes 89 common items documented, total intakes calories, nutrients, vitamins, minerals calculated for each subject.DNA was extracted...
Systemic rheumatic disease is characterized by autoimmunity and systemic inflammation affects multiple organs. Few studies have investigated whether autoimmune diseases increase the risk of dementia. Herein, we evaluate relationship between dementia through a population-based study using Korean National Health Insurance Service (NHIS) claims database.We conducted nationwide NHIS database, consisting individuals who submitted medical from 2002-2013. Dementia was defined as having an...
Abstract Although several studies reported genetic polymorphisms in protein kinase AMP ‐activated alpha 1 catalytic subunit ( PRKAA ) and their associations with gastric cancer risk, few have evaluated between Helicobacter pylori infection gene‐environment interactions. Here, we the effects of interactions H. on risk Koreans. In this hospital‐based case–control study, genotypes were analyzed CagA status examined using a serologic method 846 pairs patients controls matched for age sex....
Hyperuricemia might have neuroprotective or neurodegenerative effects on dementia via oxidative stress inflammatory response regulation. Few studies explored the association of hyperuricemia gout with dementia. This retrospective cohort study aimed to investigate between and in Korea.Altogether, 5,052 patients 25,260 age- sex-matched controls were selected from National Health Insurance Service (NHIS)-National Sample Cohort database. The incidence risk evaluated by reviewing NHIS record. We...
Considering the interactions between heavy metals, a comprehensive evaluation of effects exposure to various types co-interacting metals on health is required. This study assessed association dyslipidemia markers and blood mercury, lead, cadmium, iron, zinc, nickel levels in residents an abandoned refinery plant.
AIM:To evaluate the association between genetic polymorphisms and haplotypes of ITGA1 gene risk gastric cancer. METHODS:The study subjects were 477 age-and sex-matched case-control pairs.Genotyping was performed for 15 single nucleotide (SNPs) CONCLUSION: SNPs rs1862610 , rs24321 43 rs2447867 haplotype block that includes rs2432143 significantly associated with
이 연구는 장항제련소 주변 지역 주민들을 대상으로 중금속 노출에 의한 인체영향을 파악하기 위해 수행된 환경역학조사 결과 중 혈중 농도와 혈압 사이의 관계를 평가하기 수행되었다. 연구에는 제련소에서 4km 이내에 거주하는 570명의 30세 이상 성인 남녀가 포함되었으며 남녀별로 카드뮴, 수은 및 납 농도를 각각 3분위로 나눈 후 군별로 수축기 이완기 혈압의 차이를 비교하였다. 또한, 다중회귀분석을 통하여 이완기혈압에 영향을 주는 위험요인으로서의 중금속을 파악하였다. 남자의 경우는 카드뮴과 수은의 농도별 군에 따라 평균에 유의한 보였으나 여자의 모든 중금속의 3분위 군에서 이온기 평균이 보이지 않았다. 다중 회귀 분석의 결과에서는 경우 연령과 체질량 지수 그리고 카드뮴 농도가 혈압에 위험요인으로 나타났고, 지수, 음주 흡연, 수은이 주었다. 종합해보면, 장항 제련소 근처에 주민들은 일반인구 집단과 비교해 볼 때, 매우 높은 농도의 수치를 보여 이들은 과거 직업적 또는 환경적으로...
PP-30-063 Background/Aims: The purpose of this study was to evaluate health effects exposure crude oil by the Hebei Spirit spill occurred in Taean, Korea. Methods: subjects included 429 residents coastal areas and 275 persons living inland area. We collected information about demographic characteristics, smoking habit, alcohol consumption, number clean-up working days, so on. To on oil, we measured oxidative stress markers DNA lipids, such as 8-hydroxydeoxyguanosine (8-OHdG) malondialdehyde...
과다한 음주는 알츠하이머 및 파킨슨 질병과 같은 각종 만성 퇴행성 뇌질환의 대표적인 원인 중 하나로 알려져 있다. 체내에 유입된 에탄올은 알코올 탈수소효소(alcohol dehydrogenase, ADH)에 의해 아세트알데히드로 대사된 후 다시 알데히드탈수소효소 2(aldehyde dehydrogenase 2, ALDH2)에 아세트산으로 대사되어 배출된다. 에탄올의 대사과정 중에는 다량의 free radical이 생성되어 체내에서 산화적 스트레스를 유발하는 것으로 있고, 아세트알데히드는 활성산소를 생산하는 독성물질로 잘 본 연구에서는 8주간 에탄올에 노출된 Aldh2 knockout 마우스를 사용하여 ALDH2 효소 활성이 뇌 조직과 소변의 지질과산화에 미치는 영향에 대하여 살펴보았으며, 지질과산화 정도를 측정하기 위해 HPLC를 통한 TBARS 측정하였다. 연구결과, 마우스에서 에탄올 섭취는 조직 생성에 영향을 주지 않는 나타났으나, 소변 TBARS는 (-/-) 에탄올을...
Background: In the case of multiple exposures to different types heavy metals, such as conditions faced by residents living near a smelter, it would be preferable group hazardous substances with similar characteristics rather than individually related and evaluate effects each on human body. Objectives:The purpose this study is utility factor analysis in assessment health caused exposure two or more characteristics, smelter.Methods: Heavy metal concentration data for 572 people vicinity...
본 연구는 선행연구에서 molecular imprinting 방법을 이용하여 개발한 1-OHP 인식 <TEX>$TiO_2$</TEX>-Bead가 실제 소변중의 1-OHP를 효율적으로 검출할 수 있는지 평가하기 위해서 시행되었다. 연구에서 분석 방법은 within-day 변이계수가 4.97%, between-day 4.43%로 나타나 측정방법이 매우 안정적인 방법임을 확인할 있었다. 1-OHP와 유사한 물질들이 혼합된 용액으로부터 <TEX>$TiO_2$</TEX>-Bead-HPLC 측정방법의 회수율을 평가한 결과, 평균 105.6%의 나타내었다. 소변시료를 대상으로 기존의 효소-HPLC 측정방법과 측정방법 간의 상관성을 두 방법 간에는 높은 상관관계(r=0.74, p<0.01)를 보여 bead를 이용한 요중 1-OHP의 새로운 측정 방법의 유용성을 측정방법은 측정방법에 비해 농도를 보다 간편하고 저렴한 가격으로 측정할 있다는 장점이 있다. 연구의 결과는...
알츠하이머 질환은 인지능력과 행동능력 두 가지에 모두 영향을 미치는 진행적 노인성 치매증의 일종으로 정확한 발병기전은 아직 알려져 있지 않으나 환경적 요인 및 유전적 요인이 중요한 위험인자로 있다. 본 연구에서는 8주간 에탄올에 노출된 Aldh2 knockout mouse 뇌조직을 분리하여 질환의 지표로 잘 알려진 아밀로이드 베타와 NF-kB 발현을 평가하고 이러한 변화가 ALDH2 효소의 활성에 따라 어떻게 달라지는 지 비교하였다. 그 결과, 에탄올을 경구 투여한 마우스에서 따른 농도의 차이는 확인할 수 없었으나, 효소 활성은 알코올 노출에 의한 해마조직의 베타 축적에서 것으로 나타났다(p<0.05). 결과는 효소가 결핍된 사람이 결핍되지 않은 사람에 비해 알코올에 발생에 보다 민감할 있음을 시사한다. Alzheimer's disease (AD) is a progressive neurodegenerative disease, resulting in the loss of...
PP-29-154 Background/Aims: The purpose of this study was to investigate potential health effects associated with exposure the heavy metals in residents living near refinery plant. Methods: subjects included 572 plant and 413 controls. We collected information about demographic characteristics, dietary habits, occupational history, smoking habit, alcohol consumption, duration residence, medical history. conducted examination for all subjects, measured concentrations blood (Pb, Cd, Hg), serum...