A5031050940- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Cardiac pacing and defibrillation studies
- Cancer Treatment and Pharmacology
- Atrial Fibrillation Management and Outcomes
- Peptidase Inhibition and Analysis
- Cardiac Arrhythmias and Treatments
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Pancreatitis Pathology and Treatment
- Lung Cancer Research Studies
- Dialysis and Renal Disease Management
- Cutaneous lymphoproliferative disorders research
- Beetle Biology and Toxicology Studies
- Blood disorders and treatments
- Bladder and Urothelial Cancer Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PI3K/AKT/mTOR signaling in cancer
Hospital Clínic de Barcelona
2021-2024
Spanish Society of Hematology and Hemotherapy
2022
Instituto Cajal
2019-2021
Hospital Universitario Ramón y Cajal
2018-2020
Instituto Ramón y Cajal de Investigación Sanitaria
2020
Weatherford (Norway)
2001
Einstein Medical Center Philadelphia
1995
Immune checkpoint inhibitor (ICI) gastrointestinal toxicity (gastritis, enteritis, colitis) is a major cause of morbidity and treatment-related death. Guidelines agree steroid-refractory cases warrant infliximab, however best management infliximab-refractory ICI (IRIGItox) unknown.
Abstract Purpose Immune Checkpoint Inhibitors (ICI) can be associated with thrombotic events, both venous and arterial (VTE/AT). However, there is a paucity of information regarding patients in routine clinical practice. Methods/patients Retrospective, multicenter study promoted by the Thrombosis Cancer Section Spanish Society Medical Oncology (SEOM). Patients melanoma lung cancer who initiated ICI between 01/01/2015 31/12/2019 were recruited. Minimum follow-up was 6 months (unless it not...
Background: Despite EP (aged ≥70 years) represent the majority of patients with advanced NSCLC, efficacy and toxicity rates IT remain poorly described, as they are under-represented in clinical trials. Furthermore, age-related decline immune system might affect IT. Methods: We retrospectively reviewed NSCLC treated (antiPD-1, anti-PD-L1) monotherapy first, second subsequent-line settings, between 2014 2018 our hospital. Patient tumor features, irAEs, concomitant subsequent treatments were...
A 59 year-old woman was treated with adjuvant chemotherapy for triple negative breast cancer (TNBC) stage IB. She received pegfilgrastrim as secondary prophylaxis of neutropenia. After administration on day 11, she hospitalised because carotidynia and myocarditis that improved antibiotics steroids an infection suspected. Once recovered, another cycle administrated. At this time, the patient presented to our hospital fever, odynophagia chest pain, diagnosis coupled cardiogenic shock....
<h3>Background</h3> Intratumoral immunotherapies are being tested in different solid tumors. They trigger local and systemic responses.<sup>1 2</sup> BO-112 is a double stranded RNA nanoplexed with polyethyleneimine (PEI), which mimics viral infection mobilizes the immune system. In preclinical models first human clinical trial activated dendritic cells, induced CD-8 infiltration, apoptosis enhancement of immunogenic cell death achieved an objective response 2 out 10 patients melanoma...
Background: IT has improved outcomes in advanced NSCLC. However, this therapy can yield significant toxicity secondary to immune activation. Several retrospective studies have reported a direct relationship between efficacy and the development of irAEs, Response Rate (RR) survival. Methods: We reviewed our experience with anti-PD1/anti-PDL1 as single agent NSCLC patients treated February 2014 August 2018. Patient tumor features, concomitant subsequent treatments were collected. Stata 14.1...
Introduction: The benefit of adjuvant chemotherapy (fluoracil or capecitabine with without oxaliplatin) has been well established in the setting for node-positive colon cancer (stage III). extent to which older adults from was not different trials (MOSAIC, NSABP C-07, N016968) given that there no participation patients than 75 years old. However, latest published systematic reviews are contradictory results on efficacy this population. Methods: We retrospectively included stages II and III...
This study was performed to evaluate whether the presence of either nasal or oral gastric tubes (GTs) would affect ability accomplish transesophageal atrial pacing (TAP).After endotracheal intubation, esophageal stethoscopes were placed and TAP thresholds measured in 20 patients. With PES fixed position, GTs inserted remeasured. accomplished all patients pre- postinsertion. The mean +/- SD, range, median (mA) 13.7 5.8, 7-25, 12 preinsertion 13.9 5.2, 5.5-25, 13 preinsertion-postinsertion...
TPS9586 Background: Intratumoral immunotherapies are gaining interest in oncology, particularly melanoma. These therapies, however, have faced some issues. For instance, standard response criteria do not accurately describe tumor burden, and responses may differ for injected/non injected lesions. Besides, target lesions become non evaluable. Biomarkers provide interesting information these therapies. In addition, radiomic signatures been associated with CD-8 infiltration. BO-112 is a double...
Background: BM in HER2-positive BC patients are increasing, without agreement on the appropriate treatment of this subgroup. The disrupted blood-brain barrier setting may allow penetrance T-DM1, with little evidence its efficacy situation. Methods: treated T-DM1 monotherapy at Ramon y Cajal Hospital (Madrid) from 2012 to 2017 were eligible. We differentiated BM, stable (those who had received local for them and they not progression) progressive brain progression a treatment) beginning T-DM1....
Inflammatory breast carcinoma (IBC) is a rare form of cancer characterized by rapid onset diffuse skin erythema, edema, induration, and warmth the breast. Biologically, IBC usually hormone receptor (HR) negative experience an overexpression human epidermal growth factor 2 (HER2), with high mitotic index (MIB-1 > 20%). Median overall survival poor.1 Lapatinib oral drug that inhibits tyrosine kinases HER2 type 1 (EGFR) has demonstrated clinical activity in trastuzumab-refractory states.2 also...
Abstract After several years of reservoir evaluation in Latin America, and months planning, Weatherford UBS performed four Flowdrill operations a shallow, unconsolidated low gravity oil reservoirs North Eastern Brazil. The Reservoir is very similar to the ones encountered Orinoco River Venezuela others Southern Argentina. These wells, first their kind be conducted where great success measured by drilling, operational productivity results. Therefore technology has defined starting path...
703 Background: Primary tumor location of colon cancer (CC) is emerging as an important prognostic factor owing to distinct biological features. However, this still does not represent a parameter when deciding for adyuvant or palliative chemotherapy. In meta-analysis 66 studies including patients with all stages disease, left-sided primary was associated significantly reduced risk death and independent other factors. Methods: We retrospectively included stage II III CC that underwent...
655 Background: Adyuvant chemotherapy is a unified therapeutic principle in colon cancer (CC). However, many prognostic factors are arising to determine who really benefits from adyuvant order avoid overtreatment. Primary tumor location of CC emerging as an important factor owing distinct biological features. there hardly any evidence showing the benefit treatment according primary location. Methods: We retrospectively included patients with stage II and III that underwent surgical resection...
Introduction: The addition of oxaliplatin to fluorouracil and leucovorin as adjuvant chemotherapy (AC) for patients with stage II III colon cancer (CC) has been analyzed in two large, randomized trials, MOSAIC C-07 trials. updated results these studies showed that the enhances overall survival by approximately 5% disease but no effect disease. Methods: We retrospectively included CC were operated between 2009 2014 Ramon y Cajal University Hospital. perform a multivariable Cox model analysis...
Introduction: Oxaliplatin-based combination chemotherapy is considered standard of care for patients with stage III colorectal cancer disease. However, the benefit addition oxaliplatin to adjuvant in elderly (aged 70 years or older) not well established, because are underrepresented clinical trials. A post hoc analysis outcomes MOSAIC trial, reported Journal Clinical Oncology by Tournigand et al. as as, a recent report from ACCENT database, suggested that there was no overall disease-free...
Introduction: Pancreatic cancer is an aggressive tumor with a high mortality rate. Upon diagnosis only 15-20% of cases are amenable to surgery. Despite achieving complete resection, relapse free survival (RFS) and prognosis remain poor (RFS 60% at 12 months 20% 5-year overall (OS)). Several studies suggest that early recurrence predicts prognosis. However, cut-offs define (ER) variable between reports. The aim our study propose optimal cut-off for ER finding clinicopathological factors...
Introduction: Rates for esophageal squamous carcinomas (ESCC) have been steadily decreasing because of long-term reductions in tobacco use and alcohol consumption. However, ESCC is still a highly lethal malignancy distant metastases to the liver, bone, lung are seen nearly 30% patients. Moreover, prognosis poor, with al 5-year overall survival (OS) 10 - 20%. In patients treated curative intent, cure rate currently approaches 40%, majority recurrences develop within one year. Nevertheless, it...
Introduction: Despite surgery is a curative treatment for colon cancer (CC), recurrence common. The role of adjuvant chemotherapy (AC) in stage II CC controversial. Classically, certain factors have been associated with poor prognostic outcomes and they are widely considered the decision making algorithm CC. Methods: We conducted an unicentric retrospective study. Patients resected between 2009 2014 were identified. Univariate analysis performed classic high risk (CRF), those which obtained...