A5041578835- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV Research and Treatment
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Peripheral Artery Disease Management
- Liver Disease Diagnosis and Treatment
- Renal and Vascular Pathologies
- Drug-Induced Adverse Reactions
- Cardiovascular Health and Disease Prevention
- Renal Diseases and Glomerulopathies
- Bladder and Urothelial Cancer Treatments
- Migration and Labor Dynamics
- HIV/AIDS Impact and Responses
- Liver Disease and Transplantation
- Food Allergy and Anaphylaxis Research
- Migration, Identity, and Health
- Allergic Rhinitis and Sensitization
- Cardiovascular Function and Risk Factors
- HIV, Drug Use, Sexual Risk
- Medication Adherence and Compliance
- Mobile Health and mHealth Applications
- Diabetes Management and Education
- Hepatitis B Virus Studies
- Cardiac Imaging and Diagnostics
The University of Western Australia
2000-2024
Copenhagen University Hospital
2024
Glostrup Hospital
2024
Rigshospitalet
2024
Queen Elizabeth II Medical Centre
2007-2023
Pathwest Laboratory Medicine
2023
The Kids Research Institute Australia
2019
Université Paris Cité
2019
Sir Charles Gairdner Hospital
2019
Murdoch University
2003-2016
Nucleoside analogue reverse transcriptase inhibitor (NRTI) therapy provides sufficient conditions for progressive subcutaneous fat wasting in HIV-infected patients. As NRTI-induced host toxicity is proposed to involve cellular mitochondrial DNA (mtDNA) depletion, determinants of mtDNA copy number and mass adipocyte samples from NRTI-treated patients antiretroviral-naive controls were investigated. Adipose tissue morphology was also assessed.Subcutaneous obtained NRTI-treated, (n = 21),...
Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted viral escape mutants a critical aspect this host-virus interaction. We examined driving forces HCV evolution characterizing in vivo selective pressure(s) exerted on single amino acid residues within nonstructural protein 3 (NS3) HLA types present two host populations. Associations between polymorphisms NS3 class...
The health-related quality of life (HRQL) people living with HIV infection is an important consideration in management. PROQOL-HIV psychometric instrument was recently developed internationally as a contemporary, discriminating HIV-HRQL measure incorporating influential emotional dimensions such stigma. Here we present the first within-country results using qualitative and quantitative data collected from West Australian cohort who participated development validation PROQOL-HIV, provide...
Health-related quality of life (HRQL) is an important outcome in HIV/AIDS infection and treatment. However, most existing HIV-HRQL instruments miss issues (eg, sleeping problems, lipodystrophy). They were developed before highly active antiretroviral therapy (pre-HAART), a single language. We sought to develop contemporary instrument (PROQOL-HIV) multiple languages that accounts for HAART treatment side effects. This article details the 3-stage content validation phase PROQOL-HIV.In stage 1,...
Objective: HIV-1 protease inhibitors (versus no inhibitors) and stavudine zidovudine) are independently associated with a higher risk of lipoatrophy in HIV-infected patients. We sought to determine whether the revision and/or inhibitor-containing regimens combivir/abacavir would result prevention reversibility HIV-1-infected Design: The investigation was prospective, randomized, controlled, open-label study. Subjects: subjects included 37 individuals stable undetectable loads who were taking...
This study reports the psychometric validation of a new HIV/AIDS-specific health-related quality life (HRQL) questionnaire, Patient Reported Outcomes Quality Life-HIV. The instrument was developed simultaneously across Europe, North and South America, Africa, Asia, Australia to assess multidimensional impairments in era highly active antiretroviral therapy.A cross-sectional performed 8 countries. pilot 70-item questionnaire co-administered with HIV symptoms index, EQ-5D Medical Study-HIV...
The use of HIV protease inhibitors (PIs) as a component combination antiretroviral therapy in HIV-infected patients has been associated with dyslipidaemia, but its significance risk factor for cardiovascular disease is unclear. Endothelial dysfunction an early phase atherogenesis that may be assessed non-invasively ultrasonography vivo.To evaluate vascular function and investigate potential determinants endothelial the peripheral circulation PI-treated, men dyslipidaemia.Observational,...
Background: Electronic patient-reported outcomes (PRO) provide quick and usually reliable assessments of patients' health-related quality life (HRQL). Objective: An electronic version the Patient-Reported Outcomes Quality Life-human immunodeficiency virus (PROQOL-HIV) questionnaire was developed, its face validity reliability were assessed using standard psychometric methods. Methods: A sample 80 French outpatients (66% male, 52/79; mean age 46.7 years, SD 10.9) recruited. Paper-based...
Development of stenosis or occlusion the transjugular intrahepatic portosystemic stent shunt (TIPSS) is one major limiting factors in long–term viability this procedure. The efficacy anticoagulation with heparin which used different centers still unclear. In present study, we evaluated effect phenprocoumon on patency after TIPSS placement using Palmaz stents; 49 patients Child's A and B cirrhosis, who underwent successful were randomized into treatment group (n = 24) received a control 25)....
Abstract Background: Near‐perfect adherence to antiretroviral therapy over time is critical achieve viral suppression and recovery of functional immunity in individuals infected with HIV. The concept as a dynamic behaviour influenced by multiple biopsychosocial factors motivated us implement an integrated, multifactorial programme our hospital‐based setting. aims this study were survey the scope determinants non‐adherence patients attending Ambulatory HIV Service at Royal Perth Hospital,...
Hepatitis C virus (HCV) compromises Health-related Quality of Life (HRQL) with detriments to Physical, Mental and Social health domains. Treatment interferon ribavirin is associated side effects which further impair HRQL. New treatments appear potent, effective tolerable. However, Patient Reported Outcomes instruments that capture the impact on HRQL for people hepatitis are largely non-specific will be needed in new treatment era. Therefore, we developed a conceptually valid multidimensional...
Medetomidine (MED) is a novel, selective, alpha 2 adrenergic agonist with potent sedative, hypnotic, and analgesic properties, currently undergoing evaluation as an anesthetic adjuvant. The pharmacologic effects of MED are stereospecific, due entirely to the D-isomer (DMED), whereas L-isomer (LMED) essentially inactive. DMED, 4(5)substituted imidazole, has been shown inhibit adrenal steroidogenesis human liver microsomal alfentanil metabolism, reactions mediated by cytochrome P-450....
Background: In Australia, temporary visa holders are ineligible for Medicare and subsidised antiretroviral drugs. Additionally, HIV testing is not mandatory visas unless applicants seek work in the health sector. We sought to understand impact of issues access adherence therapy (ART) people holding permanent residents. Methods: Data were gathered from interviews with 22 participants. Information concerning medication adherence, side effects, CD4 T-cell count, viral load rate response generic...
Background. The nephrotic syndrome (NS) is associated with an increased risk of coronary heart disease. Increased oxidant stress may contribute to this by means hyperlipidaemia and/or hypoalbuminaemia. In study we assessed the contributory role stress, as measured F2‐isoprostanes and plasma oxygen radical absorbance capacity (ORAC), in subjects NS. Methods. We studied 14 NS 17 age‐ sex‐matched healthy non‐proteinuric controls. Measurement urinary was carried out using a combination silica...
Facial lipoatrophy is a frequently reported condition associated with use of antiretroviral (ARV) drugs. Poly-L-lactic acid (PLLA) has been used to correct facial in people HIV since 2004 both Europe and the United States. The objective this study was establish, real life conditions large sample, safety PLLA (New Fill®, Valeant US, Sinclair Pharma Paris, France) among HIV-positive patients. A longitudinal conducted between 2005 2008 France. Data from 4,112 treatment courses (n = patients)...
Background The consideration of health-related quality life (HRQL) is a hallmark best practice in HIV care. Information technology offers an opportunity to more closely engage patients with chronic infection their long-term management and support focus on HRQL. However, the implementation patient-reported outcome (PRO) measures, such as HRQL routine care, challenged by need synthesize data generated questionnaires, complexity collecting between patient visits, integration results into...
Unnecessary antibiotic avoidance due to allergy fears has adverse cost and health implications however, the problem is difficult resolve because patient provider-related factors leading are multifactorial. We use qualitative research methods explore perspectives of testing reach heart problem. To reveal patients report allergy, determine what education required prevent cycle erroneous reporting. The 29 were a sample convenience recruited from tertiary public hospital in Western Australia...
The clinical consequences of an antibiotic allergy label are detrimental, impacting health care delivery and patient outcomes. We assessed hospital inpatients with intent to offer free labeling (AAL) assessment within a randomized controlled trial.