Design and synthesis of a new type bischalcones as an alternative to natural synthetic are reported for the first time. Key steps involved solvent-free Claisen-Schmidt condensation chalcones, successful application diazotization-diazocoupling reaction in CNNC-linked by simple structural modification p-aminoacetophenone. The structures all compounds were confirmed means FT-IR, (1) H (13) C NMR, ESI/MS, elemental analysis. In addition, newly synthesized screened carbonic anhydrase...

Abstract Lamiaceae, a family of flowering plants, have been historically used as culinary herbs, shrubs and medicinal plants. With this study, the volatile organic compounds (VOCs) five species Lamiaceae ( Thymus cilicicus , Clinopodium nepeta L., Nepeta italica Thymbra spicata L. Ziziphora clinopodioides ) that grow in Turkey were identified by SPME/GC‐FID/MS method. The screened order to reveal their antibacterial antioxidant activities. Phenolic compound analyses performed using RP‐HPLC...

The inhibition of the two human cytosolic carbonic anhydrase (hCA; EC 4.2.1.1) isozymes I and II with some new pyrazoline derivatives was investigated for first time. structures newly synthesized were characterized by Fourier transform-infrared spectroscopy, 1 H-/13 C-nuclear magnetic resonance, mass spectrometry, elemental analysis. Compounds 1-6 showed Ki values in range 16.4-205.9 nM hCA 6.08-93.21 against II. These hydroxyl amino group-containing compounds generally competitive...

Volatile organic compounds (VOCs) of six coniferous tree barks (A. nordmanniana, P. brutia, orientalis, pinaster, sylvestris, C. libani) and nine deciduous (E. globulus, R. pseudoacacia, Q. pontica, A. glutinosa, sativa, F. tremula, equisetifolia dealbata) were analyzed by the solid phase micro extraction (SPME) method with gas chromatography-mass spectrometry (GC-FID/MS). The SPME-GC-FID/MS analysis revealed 96 VOCs in samples 83 samples. Monoterpene hydrocarbon components main constituent...

In this work, in vitro antibacterial and Leishmanicidal activities of a ligand phthalocyanine derivatives (2, 3, 3a–3c 4) were tested for six selected standard bacteria one Leishmania species. The synthesis fluorinated pyrazoline compound (2) was first carried out from chalcone precursor (1). Then, peripherally tetra-substituted metallophthalocyanines (zinc(II) (3a), cobalt(II) (3b) iron(II) (3c)) axially di-substituted silicon(IV) (4) containing groups obtained. characterizations 2, 4...

A solid phase microextraction (SPME) method with gas chromatography-mass spectrometry (GC-MS) was used for analyses of the volatile compounds six Geranium species; G. asphodeloides, psilostemon, purpureum, pyrenaicum, robertianum and sanguineum. The results were compared those obtained by hydrodistillation. According to study, major identified in SPME extracts sabinen (33.5%) (G. asphodeloides), caryophyllene (34.1%, 21.7%, 11.2%) purpureum robertianum), germacrene D (25.2%) pyrenaicum),...

This study was performed to determine the antibacterial activity of methanol extracts 23 bryophyte species against Paenibacillus larvae isolates that cause American foulbrood diseases in honeybee larvae. The honey and larva samples were collected from nine different locations Rize Turkey. A total 22 gram-positive spore-forming bacteria isolated samples. According results morphological, biochemical, molecular (16S rRNA gene sequencing) tests, 10 identified as P. (Polytrichum formasum,...

In this study, hydroxy benzoin ( 1-7 ), benzil 8-14 and benzoin/benzil-O-β-D-glucosides 15-25 ) were synthesized to investigate their biological activities. An efficient method for synthesizing compounds 1 - 7 was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, DPPH), antimicrobial (3 Gram (-), 4/6 (+), one tuberculosis fungus), enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, α-amylase, α- glucosidase) the...

Volatile compounds of three Stachys species; macrantha (C. Koch) Stearn, sylvatica L. and annua ssp. var. were analyzed by a solid phase micro extraction (SPME) method coupled with gas chromatographyflame ionization detector (GC–FID) chromatographymass spectrometry (GC-MS). A total 38 (99.2%), 39 (99.0%) 33 (98.8%) volatile identified from S. annua, respectively. The major constituents the investigated species were; α-pinene (11.2%), p-cymene (18.2%), carvacrol (28.8%) in macrantha,...

Seven novel carbohydrate conjugates of new chalcone-3- O-glycosides were synthesized and characterized. Starting from the substituted 3′-hydroxyarylmethylacetophenone derivatives (chalcones) with α-acetobromoglucose in anhydrous acetone 2,3,4,6-tetra- O-acetyl-3′- O-β-d-glucopyranosyloxychalcones. Deblocking latter CH 3 ONa dry methanol results (3′- O-β-d-glucopyranosyloxychalcones). The structures newly characterized based on 1 H nuclear magnetic resonance, 13 C mass spectroscopy,...

In this study, some novel mono- and di-O-β-D-glycopyranosyl chalcone analogs were designed, synthesized, characterized. The derivatives synthesized with good yields by base-catalyzed Claisen-Schmidt condensation in EtOH solution. Then these chalcones reacted TAGBr (2,3,4,6-tetra-O-acetyl-μ-D-glucopyranosylbromide) dry acetone under the anhydrous condition at 0-5 °C. Deacylated was carried out Zemplen's method NaOCH3 methanol results substituted chalcone-O-glycosides (mono- analogs). chemical...

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by malar rash, oral ulcers, arthralgia, photosensitivity and nephritis. Herein, we report a rare comorbidity, multiple avascular necrosis (AVN), in adolescent SLE patient also highlight the importance of risk factors for this comorbidity with brief literature review. A 13-year-old female was admitted severe headache, visual plus auditory hallucinations, polyarthritis history recurrent ulcers. Acneiform arthritis,...

The synthesis of novel metallophthalocyanines (M = Zn, Mg, and Co) derived from ( E)-3-(3-bromophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one E)-3-(3-fluorophenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one is achieved. These complexes the synthesized phthalonitrile derivatives are characterized by FTIR, 1 H NMR, 13 C UV-Vis, mass spectrometry, elemental analysis. aggregation properties ZnPc, MgPc, CoPc investigated in different solvents at concentrations dimethyl formamide. electrochemical behavior...

The aim of this study was to investigate the chemical composition essential oils (EOs) from two Diplophyllum species and evaluate their bioactivity potential [antimicrobial, antioxidant, anti-urease, anti-xanthine oxidase (XO)], phenolic compounds. analysis albicans taxifolium permitted identification 62 components, comprising ? 99.6% total EO composition. major components found in these liverwort were ?-patchoulene, ?-santalene, ?-himachalene, cubebol. antimicrobial assays showed that...

Volatile compounds of three Stachys species; macrantha (C. Koch) Stearn , sylvatica L. and annua ssp. var. were analyzed by a solid phase micro extraction (SPME) method with gas chromatography-mass spectrometry (GC-MS). A total 38 (99.2%), (99.0%) 32 (98.8%) volatile identified different constituents from S. annua, respectively. The major the investigated species were; α -pinene (11.2%), p -cymene (18.2%), carvacrol (28.8%) in γ -muurolene (10.2%), -cedrene limonene (37.0%) (11,4%), β...

Abstract The structural, spectroscopic and electronic properties of newly synthesized 3-Hydroxy-2-(4-chlorophenyl)-7-fluoro-4H-chromen-4-one have been analyzed by using single crystal X-ray diffraction, 1H 13C NMR chemical shifts, FT-IR UV-Vis. methods both theoretically experimentally. geometrical optimization parameters (bond lengths angles), vibrational wavenumbers, proton carbon transations, the highest occupied molecular orbital (HOMO) lowest unoccupied (LUMO) analyses, Molecular...

<title>Abstract</title> <bold>Objective: </bold>This study aims to evaluate the relationship between serum melatonin levels, sleep habits, and clinical features in children with autism spectrum disorder (ASD) compared healthy controls. <bold>Methods: </bold>In accordance DSM (The Diagnostic Statistical Manual of Mental Disorders)-V, aged 2-8 years diagnosed (n:38) (n:33) similar age gender control group were evaluated. Vitamin D ferritin, iron, iron binding capacity all participants...

Phthalonitrile derivatives (8, 9, and 10) bearing different chalcone groups their zinc(II) (ZnPcs) (8a, 9a, 10a) magnesium(II) (MgPcs) (8b, 9b, 10b) complexes were prepared. The new compounds (5, 8–10, 8a–10a, 8b–10b) characterized by a combination of spectroscopic techniques, such as FT-IR, 1H NMR, 13C NMR (for 5, 8, 10), UV–Vis metallophthalocyanines), MALDI-TOF mass spectra, elemental analysis 10). aggregation behavior photophysical (fluorescence quantum yields lifetimes) photochemical...