A5101692808- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Ischemic Stroke Management
- Thyroid Disorders and Treatments
- Blood properties and coagulation
- Total Knee Arthroplasty Outcomes
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Orthopaedic implants and arthroplasty
- Peroxisome Proliferator-Activated Receptors
- Sleep and related disorders
- Pressure Ulcer Prevention and Management
- Apelin-related biomedical research
- Pancreatic function and diabetes
- Sleep and Wakefulness Research
- Renin-Angiotensin System Studies
- Parathyroid Disorders and Treatments
- FOXO transcription factor regulation
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Health Systems, Economic Evaluations, Quality of Life
- Blood disorders and treatments
- Thyroid Cancer Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Peptidase Inhibition and Analysis
Sun Yat-sen Memorial Hospital
2009-2025
Sun Yat-sen University
2007-2025
Shanghai Clinical Research Center
2025
Fifth Affiliated Hospital of Sun Yat-sen University
2007
Diabetic foot ulceration is receiving more attention because of its high amputation and mortality rate. It essential to establish the frequency amputations in people with diabetes after any change management diabetic care. The present study aim compare lower-extremity patients ulcer over a ten-year period.Six hundred forty eight were retrospectively studied from 2004 2013. clinical features, laboratory results recorded. Major was defined as above ankle while minor below study.Patients old...
Dysthyroid optic neuropathy (DON) is the most serious complication associated with Graves' orbitopathy (GO). The primary treatment approach for DON high-dose intravenous methylprednisolone infusion and decompression surgery. However, not all patients are suitable candidates or can tolerate these two options. Here, we present a patient diagnosed in left eye central serous chorioretinopathy (CSC) right eye. Considering that glucocorticoids contraindicated CSC refused orbital surgery, opted...
Both obesity and subclinical hypothyroidism (SCH) have adverse effects on human body, but the relationship between these two conditions remains inconsistent. The presence of thyroid autoantibodies influences hormone levels, may further mediate interaction SCH. This study aimed to explore association among obesity, SCH autoantibodies.This was a cross-sectional survey 2505 subjects. Obesity defined as body mass index ≥28 kg/m2. Serum concentrations hormones, peroxidase antibody (TPO-Ab)...
Objective The results of studies on association between -148C/T polymorphism in promoter region β-fibrinogen gene and susceptibility to cerebral infarction Chinese population are controversial. In this study, we summarize the published works field by a meta-analysis. Data sources Genetic evaluating polymorphisms involving before December 2005 were collected from PubMed, EMBASE CNKI. Study selection Case control unrelated, Han subjects aged 18 80 years, internationally recognized diagnostic...
Objectives A variety of factors differed between rural and urban areas may further influence iodine status thyroid structure. Hence, this study compared nutrition, the prevalence goiter, nodules residents in Guangzhou, a southern coastal city China. Methods total 1211 1305 were enrolled cross-sectional study. questionnaire regarding personal characteristics was administered. Urinary concentration (UIC) examined. Ultrasonography performed to evaluate goiter nodules. Multiple logistic analysis...
Sleep plays a critical role in maintaining human health. This study aimed to explore the association between sleep status and thyroid nodules.A total of 2414 individuals aged 18 or older with euthyroidism were enrolled this community-based survey. was self-reported. Thyroid ultrasonography performed measure nodules. Multiple logistic analyses applied adjust for confounding factors.The percentages nodules among who slept <5 hours, 5-8 >8 hours per night 57.79% (115/199), 44.19% (833/1885)...
The RAS system is involved in the regulation of islet function, but its remains unclear. This study investigates role an islet-specific miR-375 effect on β-cells. mimics and inhibitors were transfected into insulin-secreting MIN6 cells presence or absence component. Compared to control, Ang II-treated cells, mimic transfection results a decrement cell viability Akt-Ser levels (0.739±0.05 vs. 0.883±0.06 0.40±0.04 0.79±0.04, respectively), while opposite occurred inhibitor-transfected...
Chronic kidney disease (CKD) has become a major global health issue, and abnormalities of glucose metabolism are risk factor responsible for development CKD. We aimed to investigate associations between indices CKD in Chinese population determine which index is superior predicting incident performed community-based on 5232 subjects aged ≥40 years without baseline was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 or urinary albumin-to-creatinine ratio (UACR)...
China now has the highest number of diabetes in world. Angiotensin II (Ang II) causes insulin resistance by acting on signaling pathway peripheral target tissues. However, its effect islet β-cells remains unclear. The possible role Angiotensin-( 1-7) [Ang-(1-7)] as an antagonist to effects Ang and treating needs be elucidated.
Background Chronic kidney disease (CKD) has become a major global health issue, and abnormalities of glucose metabolism are risk factor responsible for development CKD. We aimed to investigate associations between indices CKD in Chinese population, determine which index is superior predicting incident Methods This community-based population study included 5232 subjects aged ≥40 years without baseline was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or urinary...
Objective To explore the effect of tissue inhibitor metalloproteinase 1 (TIMP-1) on biological behaviors rat dermal fibroblast with high matrix 9 (MMP-9), in order to provide an experimental basis for looking a new way treat diabetic foot. Methods The cell model skin was established by using line CRL-1213 from SD rats expression MMP-9 glucose (22.0 mmol/L) + homocysteine (100 μmol/L) co-culture. Exogenous TIMP-1 used inhibite activity MMP-9. Realtime PCR and ELISA were detect mRNA...
The effect of globular adiponectiin (gAd)on the function NIT-1 cells under high glucose medium was investigated. results showed that gad could completely block increase NADPH oxidase components p47phox expression and recover mRNA pancreatic duodenal homeobox-I ,paired box gene 6,glucose transpoter 2,and glucokinase except neurogenic differentiation factor 1 (P<0.05 or P<0.01). Whereas,impaired insulin secretion at concentration were not significantly improved by gAd. Key words: NIT-I...